Results 81 to 90 of about 391,633 (331)

Analysis of Interstellar Extinction towards the Hypergiant Cyg OB2 No. 12

open access: yesOpen Astronomy, 2016
The Cyg OB2 stellar association hosts an entire zoo of unique objects, and among them – an enigmatic star Cyg OB2 No. 12 (Schulte 12, MT 304). MT 304 is enigmatic not only due to its highest luminosity (according to various estimates, it is one of the ...
Maryeva O. V.   +3 more
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

The Response of Tropical Rainfall to Idealized Small‐Scale Thermal and Mechanical Forcing

open access: yesGeophysical Research Letters
Predicting the spatiotemporal distribution of rainfall remains a key challenge in Tropical Meteorology, partly due to an incomplete understanding of the effects of different environmental factors on atmospheric convection.
Martin Velez‐Pardo, Timothy W. Cronin
doaj   +1 more source

High-Resolution Spectroscopy of Cool Carbon-Rich and Metal-Poor Star HD 209621

open access: yesOpen Astronomy, 2012
Element abundances for HD 209621 obtained earlier display significant discrepancies, especially in the case of CNO and neutron-capture elements. Therefore we performed a detailed analysis of chemical composition of this star using a new high-resolution ...
Matrozis E., Začs L., Barzdis A.
doaj   +1 more source

Three-dimensional simulations of near-surface convection in main-sequence stars - II. Properties of granulation and spectral lines

open access: yes, 2013
The atmospheres of cool main-sequence stars are structured by convective flows from the convective envelope that penetrate the optically thin layers and lead to structuring of the stellar atmospheres analogous to solar granulation.
Beeck, Benjamin   +3 more
core   +2 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Pathicity: Experiencing the World in an Atmospheric Way

open access: yesOpen Philosophy, 2019
Is there really an atmospheric turn? The concept of “atmosphere” as a qualitative-emotional prius of sensory experience seems today to have encouraged the convergence of many interdisciplinary studies focused on the qualitative aspects of our ...
Griffero Tonino
doaj   +1 more source

Observations of Exoplanet Atmospheres

open access: yes, 2015
Detailed characterization of an extrasolar planet's atmosphere provides the best hope for distinguishing the makeup of its outer layers, and the only hope for understanding the interplay between initial composition, chemistry, dynamics & circulation, and
Crossfield, Ian J. M.
core   +1 more source

Radioactivity in the Atmosphere [PDF]

open access: yesRadiochimica Acta, 1995
A short review is made on atmospheric radionuclides with emphasis on their activity concentrations in the troposphere, mostly for surface air over Europe. Discussed are those species which have activity concentrations above about 1 mBq/m3. For this atmospheric layer highest average activity concentrations (> 1 Bq/m3) have i) 222Rn ("radon") and its ...
openaire   +4 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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