Results 81 to 90 of about 482,225 (294)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

A simple model to estimate atmospheric concentrations of aerosol chemical species based on snow core chemistry at Summit, Greenland [PDF]

, 1995
A simple model is presented to estimate atmospheric concentrations of chemical species that exist primarily as aerosols based on snow core/ice core chemistry at Summit, Greenland. The model considers the processes of snow, fog, and dry deposition.
Bergin, M H, Davidson, C, Dibb, Jack E., Jaffrezo, J L, Kuhns, H D, Pandis, S N   +5 more
core   +2 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

How does the local wind field control the aerosol distribution in coastal Dronning Maud Land? [PDF]

, 2011
Atmospheric circulation patterns and chemical concentrations in firn cores are highly related to each other. Atmospheric winds transport aerosols like sea salt and mineral dust over the globe and redistribute them.
Bigler, M., Fischer, Hubertus, Schmidt, Katrin, Wegner, Anna, Weller, Rolf   +4 more
core  

Modelling the Inorganic Bromine Partitioning in the Tropical Tropopause over the Pacific Ocean [PDF]

, 2016
The stratospheric inorganic bromine burden (Bry) arising from the degradation of brominated very short-lived organic substances (VSL org ), and its partitioning between reactive and reservoir species, is needed for a comprehensive assessment of the ozone
Atlas, Elliot, Cuevas, Carlos Alberto, Elkins, James W., Fernandez, Rafael Pedro, Hintsa, Eric J., Kinnison, Douglas E., Lamarque, Jean Francois, Moore, Fred L., Navarro, María A., Rodriguez Lloeveras, Xavier, Rollins, Andrew, Saiz-lopez, Alfonso, Thornberry, Troy, Tilmes, Simone   +13 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Impact of a monotonic advection scheme with low numerical diffusion on transport modeling of emissions from biomass burning

Journal of Advances in Modeling Earth Systems, 2012
An advection scheme, which maintains the initial monotonic characteristics of a tracer field being transported and at the same time produces low numerical diffusion, is implemented in the Coupled Chemistry-Aerosol-Tracer Transport model to the Brazilian ...
Saulo Frietas, Luiz F. Rodrigues, Karla M. Longo, Jairo Panetta   +3 more
doaj  

A Review on the Bulk and Surface Chemistry of Iron in Atmospherically-relevant Systems Containing Humic Like Substances (HULIS) [PDF]

, 2015
As the fourth most abundant element by mass in the Earth’s crust, iron is ubiquitous and its chemistry is rich and interdisciplinary in nature. This review synthesizes the current state of knowledge of iron chemistry in multicomponent atmospheric ...
Al-Abadleh, Hind A.
core   +1 more source