Results 81 to 90 of about 3,727,608 (358)

Atmospheric CO2 effect on stable carbon isotope composition of terrestrial fossil archives

Nature Communications, 2018
The 13C/12C ratio of C3 plant matter is thought to be controlled by the isotopic composition of atmospheric CO2 and stomatal response to environmental conditions, particularly mean annual precipitation (MAP).
Vincent J. Hare, E. Loftus, A. Jeffrey, C. Ramsey   +3 more
semanticscholar   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Light-absorption of dust and elemental carbon in snow in the Indian Himalayas and the Finnish Arctic [PDF]

Atmospheric Measurement Techniques, 2018
Light-absorbing impurities (LAIs) deposited in snow have the potential to substantially affect the snow radiation budget, with subsequent implications for snow melt.
J. Svensson, J. Ström, N. Kivekäs, N. B. Dkhar, N. B. Dkhar, S. Tayal, S. Tayal, V. P. Sharma, V. P. Sharma, A. Jutila, A. Jutila, J. Backman, A. Virkkula, M. Ruppel, A. Hyvärinen, A. Hyvärinen, A. Kontu, H.-R. Hannula, M. Leppäranta, R. K. Hooda, R. K. Hooda, A. Korhola, E. Asmi, H. Lihavainen   +23 more
doaj   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Measurement report: Wintertime aerosol characterization at an urban traffic site in Helsinki, Finland [PDF]

Atmospheric Chemistry and Physics
Physical and chemical properties of particulate matter and concentrations of trace gases were measured at an urban site in Helsinki, Finland, for 5 weeks to investigate the effect of wintertime conditions on pollutants.
K. Teinilä, S. Saarikoski, H. Lintusaari, T. Lepistö, P. Marjanen, M. Aurela, H. Hellén, T. Tykkä, M. Lampimäki, J. Lampilahti, L. Barreira, T. Mäkelä, L. Kangas, J. Hatakka, S. Harni, J. Kuula, J. V. Niemi, H. Portin, J. Yli-Ojanperä, J. Yli-Ojanperä, V. Niemelä, M. Jäppi, K. Lehtipalo, K. Lehtipalo, J. Vanhanen, L. Pirjola, L. Pirjola, H. E. Manninen, T. Petäjä, T. Rönkkö, H. Timonen   +30 more
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

The ENSO signal in atmospheric composition fields: emission-driven versus dynamically induced changes

, 2015
. The El Nino–Southern Oscillation (ENSO) not only affects meteorological fields but also has a large impact on atmospheric composition. Atmospheric composition fields from the Monitoring Atmospheric Composition and Climate (MACC) reanalysis are used to ...
A. Inness, A. Benedetti, J. Flemming, V. Huijnen, J. Kaiser, M. Parrington, S. Rémy   +6 more
semanticscholar   +1 more source

Isotopic composition of daily precipitation along the southern foothills of the Himalayas: impact of marine and continental sources of atmospheric moisture

Atmospheric Chemistry and Physics, 2017
. The flow of the Himalayan rivers, a key source of fresh water for more than a billion people primarily depends upon the strength, behaviour and duration of the Indian summer monsoon (ISM) and the western disturbances (WD), two contrasting circulation ...
G. Jeelani, R. D. Deshpande, Michał Gałkowski, K. Różański   +3 more
semanticscholar   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Limitation of Atmospheric Composition by Combustion–Explosion in Exoplanetary Atmospheres [PDF]

The Astrophysical Journal, 2018
Abstract This work presents theoretical studies that combine aspects of combustion and explosion theory with exoplanetary atmospheric science. Super-Earths could possess a large amount of molecular hydrogen depending on disk, planetary, and stellar properties.
John Lee Grenfell, Barbara Stracke, Mareike Godolt, Stefanie Gebauer, Heike Rauer, Heike Rauer, Ralph Lehmann   +6 more
openaire   +5 more sources