Results 61 to 70 of about 100,704 (268)

Composition of Titan's Atmosphere [PDF]

, 2021
As a result of the 13-year exploration of the Saturn system by the Cassini-Huygens mission (2004–17), there has been a revolution in our understanding of Titan, Saturn's largest satellite. Titan's atmosphere shows the most complex chemistry in the solar system.
openaire   +3 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Soot Particle Agglomeration Inlet (SPAI) for Enabling Online Chemical Composition Measurement of Nanoparticles with the Aerosol Mass Spectrometer

Aerosol and Air Quality Research, 2021
Nanoparticles are a topic of interest because of their effects on human health and the climate, but the current options for evaluating their chemical composition—one of the key properties that determine the mechanisms of these effects—remain very limited
Sampsa Martikainen, Sanna Saarikoski, Paxton Juuti, Hilkka Timonen, Jorma Keskinen, Panu Karjalainen   +5 more
doaj   +1 more source

Numerical study of the atmospheric composition in Bulgaria

Computers & Mathematics with Applications, 2013
The present work aims at studying the local to regional atmospheric pollution transport and transformation processes over Bulgaria and at tracking and characterizing the main pathways and processes that lead to atmospheric composition formation in the region. The US EPA Models-3 system is chosen as a modeling tool. As the NCEP Global Analysis Data with
Georgi Gadzhev, Kostadin Ganev, Nikolai Miloshev, Dimiter Syrakov, Maria Prodanova   +4 more
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Measurement report: Wintertime aerosol characterization at an urban traffic site in Helsinki, Finland [PDF]

Atmospheric Chemistry and Physics
Physical and chemical properties of particulate matter and concentrations of trace gases were measured at an urban site in Helsinki, Finland, for 5 weeks to investigate the effect of wintertime conditions on pollutants.
K. Teinilä, S. Saarikoski, H. Lintusaari, T. Lepistö, P. Marjanen, M. Aurela, H. Hellén, T. Tykkä, M. Lampimäki, J. Lampilahti, L. Barreira, T. Mäkelä, L. Kangas, J. Hatakka, S. Harni, J. Kuula, J. V. Niemi, H. Portin, J. Yli-Ojanperä, J. Yli-Ojanperä, V. Niemelä, M. Jäppi, K. Lehtipalo, K. Lehtipalo, J. Vanhanen, L. Pirjola, L. Pirjola, H. E. Manninen, T. Petäjä, T. Rönkkö, H. Timonen   +30 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evaluation of the performance of a particle concentrator for online instrumentation [PDF]

Atmospheric Measurement Techniques, 2014
The performance of the miniature Versatile Aerosol Concentration Enrichment System (m-VACES; Geller et al., 2005) was investigated in laboratory and field studies using online instruments. Laboratory tests focused on the behavior of monodisperse ammonium
S. Saarikoski, S. Carbone, M. J. Cubison, R. Hillamo, P. Keronen, C. Sioutas, D. R. Worsnop, J. L. Jimenez   +7 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source