Results 41 to 50 of about 100,704 (268)

Validation of TROPOMI and WRF-Chem NO₂ across seasons using SWING+ and surface observations over Bucharest [PDF]

Atmospheric Chemistry and Physics
Nitrogen oxides (NOx) are key pollutants involved in ozone and particulate matter formation, with strong spatial variability near urban sources. Accurate monitoring of tropospheric nitrogen dioxide (NO2) is essential for air quality management and relies
A. Pasternak, J.-F. Müller, C. Poraicu, A. Merlaud, F. Tack, T. Stavrakou   +5 more
doaj   +1 more source

Terpenoid and carbonyl emissions from Norway spruce in Finland during the growing season [PDF]

Atmospheric Chemistry and Physics, 2017
We present spring and summer volatile organic compound (VOC) emission rate measurements from Norway spruce (Picea abies L. Karst) growing in a boreal forest in southern Finland.
H. Hakola, V. Tarvainen, A. P. Praplan, K. Jaars, M. Hemmilä, M. Kulmala, J. Bäck, H. Hellén   +7 more
doaj   +1 more source

Methane exchange at the peatland forest floor – automatic chamber system exposes the dynamics of small fluxes [PDF]

Biogeosciences, 2017
We measured methane (CH4) exchange rates with automatic chambers at the forest floor of a nutrient-rich drained peatland in 2011–2013. The fen, located in southern Finland, was drained for forestry in 1969 and the tree stand is now a mixture of Scots ...
M. Korkiakoski, J.-P. Tuovinen, M. Aurela, M. Koskinen, K. Minkkinen, P. Ojanen, T. Penttilä, J. Rainne, T. Laurila, A. Lohila   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Measurement report: The effects of SECA regulations on the atmospheric SO₂ concentrations in the Baltic Sea, based on long-term observations on the Finnish island, Utö [PDF]

Atmospheric Chemistry and Physics
The designation of the Baltic Sea as a sulfur emission control area (SECA) in May 2006, with subsequent tightening of regulations in 2010 and 2015, has reduced the sulfuric emission from shipping traffic.
A. Maragkidou, T. Grönholm, L. Rautiainen, J. Nikmo, J.-P. Jalkanen, T. Mäkelä, T. Anttila, L. Laakso, L. Laakso, J. Kukkonen, J. Kukkonen   +10 more
doaj   +1 more source

Characterization of trace metals on soot aerosol particles with the SP-AMS: detection and quantification [PDF]

Atmospheric Measurement Techniques, 2015
A method to detect and quantify mass concentrations of trace metals on soot particles by the Aerodyne soot-particle aerosol mass spectrometer (SP-AMS) was developed and evaluated in this study.
S. Carbone, T. Onasch, S. Saarikoski, H. Timonen, K. Saarnio, D. Sueper, T. Rönkkö, L. Pirjola, A. Häyrinen, D. Worsnop, R. Hillamo   +10 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The applicability and challenges of black carbon sensors in monitoring networks [PDF]

Aerosol Research
Black carbon (BC) is a particulate pollutant emitted as a by-product of combustion. BC has an emerging role in air quality monitoring with the current recommendations by the World Health Organization to monitor BC to capture its temporal and spatial ...
J. T. Elomaa, K. Luoma, K. Luoma, S. D. Harni, A. Virkkula, H. Timonen, T. Petäjä   +6 more
doaj   +1 more source

Snow Samples Combined With Long-Range Transport Modeling to Reveal the Origin and Temporal Variability of Black Carbon in Seasonal Snow in Sodankylä (67°N)

Frontiers in Earth Science, 2020
In the Arctic areas, the influence of global climate change is enhanced. Enabling a better understanding of the changes in the Arctic environment is of the utmost importance.
Outi Meinander, Anna Kontu, Rostislav Kouznetsov, Rostislav Kouznetsov, Mikhail Sofiev   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source