Results 51 to 60 of about 100,704 (268)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Effects of ship emissions on air quality in the Baltic Sea region simulated with three different chemistry transport models [PDF]

Atmospheric Chemistry and Physics, 2019
The Baltic Sea is a highly frequented shipping area with busy shipping lanes close to densely populated regions. Exhaust emissions from ship traffic into the atmosphere do not only enhance air pollution, they also affect the Baltic Sea environment ...
M. Karl, J. E. Jonson, A. Uppstu, A. Aulinger, M. Prank, M. Prank, M. Sofiev, J.-P. Jalkanen, L. Johansson, M. Quante, V. Matthias   +10 more
doaj   +1 more source

Effects of Different Aerosols on the Air Pollution and Their Relationship With Meteorological Parameters in North China Plain

Frontiers in Environmental Science, 2022
Located in East Asia, the North China Plain (NCP) has a severe air pollution problem. In this study, variations in visibility, particulate matter (PM), gaseous pollutants, vertical meteorological parameters, and different types of aerosols and their ...
Hujia Zhao, Ke Gui, Yanjun Ma, Yangfeng Wang, Yaqiang Wang, Hong Wang, Yuanyuan Dou, Yu Zheng, Lei Li, Lei Zhang, Yuqi Zhang, Huizheng Che, Xiaoye Zhang   +12 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

SO₂ noontime-peak phenomenon in the North China Plain [PDF]

Atmospheric Chemistry and Physics, 2014
A phenomenon of frequent noontime SO2 concentration peaks was discovered in a detailed analysis of the SO2 concentrations in the North China Plain (NCP). The possible causes and their contributions are analyzed.
W. Y. Xu, C. S. Zhao, L. Ran, W. L. Lin, P. Yan, X. B. Xu   +5 more
doaj   +1 more source

ATMOSPHERIC CIRCULATION AND COMPOSITION OF GJ1214b [PDF]

The Astrophysical Journal, 2011
14 pages, 4 figures, 1 table, accepted for publication in ...
openaire   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Light-absorption of dust and elemental carbon in snow in the Indian Himalayas and the Finnish Arctic [PDF]

Atmospheric Measurement Techniques, 2018
Light-absorbing impurities (LAIs) deposited in snow have the potential to substantially affect the snow radiation budget, with subsequent implications for snow melt.
J. Svensson, J. Ström, N. Kivekäs, N. B. Dkhar, N. B. Dkhar, S. Tayal, S. Tayal, V. P. Sharma, V. P. Sharma, A. Jutila, A. Jutila, J. Backman, A. Virkkula, M. Ruppel, A. Hyvärinen, A. Hyvärinen, A. Kontu, H.-R. Hannula, M. Leppäranta, R. K. Hooda, R. K. Hooda, A. Korhola, E. Asmi, H. Lihavainen   +23 more
doaj   +1 more source