Results 31 to 40 of about 68,328 (248)

Atmospheric continuous-variable quantum communication

New Journal of Physics, 2014
We present a quantum communication experiment conducted over a point-to-point free-space link of 1.6 km in urban conditions. We study atmospheric influences on the capability of the link to act as a continuous-variable (CV) quantum channel. Continuous polarization states (that contain the signal encoding as well as a local oscillator in the same ...
Heim, Bettina, Peuntinger, Christian, Killoran, Nathan, Khan, Imran, Wittmann, Christoffer, Marquardt, Christoph, Leuchs, Gerd   +6 more
openaire   +5 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intraseasonal atmospheric variability under climate trends

Chaos: An Interdisciplinary Journal of Nonlinear Science
Low-order climate models have played an important role in understanding the low-frequency variability of the atmospheric circulation and how it can be affected by trends in anthropogenic forcing. A simple quasi-geostrophic model of the midlatitudes’ circulation (Lorenz, Tellus, 1984, 1990) is studied from the perspective of the theory of ...
B. Maraldi, H. A. Dijkstra, M. Ghil
openaire   +4 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Benchmarking Northern Hemisphere midlatitude atmospheric synoptic variability in centennial reanalysis and numerical simulations

Geophysical Research Letters, 2016
The representation of midlatitude winter atmospheric synoptic variability in centennial reanalysis products, which assimilate surface observations only, and atmospheric model simulations constrained by observation‐based data sets is assessed. Midlatitude
Alessandro Dell'Aquila, Susanna Corti, Antje Weisheimer, Hans Hersbach, Carol Peubey, Paul Poli, Paul Berrisford, Dick Dee, Adrian Simmons   +8 more
doaj   +1 more source

Diurnal Variability of Persistent Organic Pollutants in the Atmosphere over the Remote Southern Atlantic Ocean

Atmosphere, 2014
A diel (24-h) cycle with daytime atmospheric concentrations higher than nighttime concentrations by a factor of 1.5–3 was observed for several low molecular weight polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) in remote ...
Rosalinda Gioia, Matthew MacLeod, Javier Castro-Jiménez, Luca Nizzetto, Jordi Dachs, Rainer Lohmann, Kevin C. Jones   +6 more
doaj   +1 more source

External Forcing Explains Recent Decadal Variability of the Ocean Carbon Sink

AGU Advances, 2020
The ocean has absorbed the equivalent of 39% of industrial‐age fossil carbon emissions, significantly modulating the growth rate of atmospheric CO2 and its associated impacts on climate.
Galen A. McKinley, Amanda R. Fay, Yassir A. Eddebbar, Lucas Gloege, Nicole S. Lovenduski   +4 more
doaj   +1 more source

A Multiannual Record of Convective Instability in Mars’s Middle Atmosphere from the Mars Climate Sounder

The Planetary Science Journal, 2023
Gravity waves (GW) transfer energy and momentum from the lower to the middle and upper atmospheres of Earth and Mars. Momentum transfer can occur through the wave dissipative process of saturation associated with convective or shear instability.
Nicholas G. Heavens, Alexey Pankine, J. Michael Battalio, Corwin Wright, David M. Kass, Armin Kleinböhl   +5 more
doaj   +1 more source

Temporal Variability in Hot Jupiter Atmospheres [PDF]

The Astrophysical Journal, 2019
Abstract Hot Jupiters receive intense incident stellar light on their daysides, which drives vigorous atmospheric circulation that attempts to erase their large dayside-to-nightside flux contrasts. Propagating waves and instabilities in hot Jupiter atmospheres can cause emergent properties of the atmosphere to be time-variable.
Thaddeus D. Komacek, Adam P. Showman
openaire   +2 more sources