Results 51 to 60 of about 1,916,947 (303)

Southern hemisphere atmospheric circulation: Impacts on Antarctic climate and reconstructions from Antarctic ice core data [PDF]

, 2010
The official pulished version can be accessed from the DOI below - Copyright @ 2010 Springer VerlagThe atmospheric circulation patterns in the Southern Hemisphere have had a significant impact on the climate of the Antarctic and there is much evidence ...
McGregor, G R, Russell, A, McGregor, G.R., Russell, A.   +3 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Internal Atmospheric Variability and Interannual-to-Decadal ENSO Variability in a CGCM

, 2009
The interactive ensemble coupling strategy has been developed specifically to determine how noise due to internal atmosphere dynamics impacts climate variability within the context of coupled general circulation models (CGCMs).
Kirtman, Ben P., Yeh, Sang-Wook, Kirtman, Ben P   +2 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Response of the Antarctic Circumpolar Current to Atmospheric Variability [PDF]

Journal of Climate, 2008
Abstract Historical hydrographic profiles, combined with recent Argo profiles, are used to obtain an estimate of the mean geostrophic circulation in the Southern Ocean. Thirteen years of altimetric sea level anomaly data are then added to reconstruct the time variable sea level, and this new dataset is analyzed to identify and monitor ...
Sallee, J.B., Morrow, R., Speer, K.
openaire   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Benchmarking Northern Hemisphere midlatitude atmospheric synoptic variability in centennial reanalysis and numerical simulations

Geophysical Research Letters, 2016
The representation of midlatitude winter atmospheric synoptic variability in centennial reanalysis products, which assimilate surface observations only, and atmospheric model simulations constrained by observation‐based data sets is assessed. Midlatitude
Alessandro Dell'Aquila, Susanna Corti, Antje Weisheimer, Hans Hersbach, Carol Peubey, Paul Poli, Paul Berrisford, Dick Dee, Adrian Simmons   +8 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Teleconnection Strength and Network Design Control Reconstruction Skill of North Atlantic Climate Modes

Atmospheric Science Letters
Reconstructing the North Atlantic Oscillation (NAO) and East Atlantic (EA) Pattern is crucial for understanding past climate variability and improving climate predictions.
Larissa N. van derLaan, Anna Kirchner, Simon P. Heselschwerdt, Jens Hesselbjerg Christensen   +3 more
doaj   +1 more source