Results 31 to 40 of about 76,510 (267)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

No Robust Sign of Human Influence in the Unprecedented Atmospheric Circulation of Summer 2018 Over Northern Europe

Earth's Future
The summer of 2018 was characterized by prolonged heatwaves over Northern Europe, associated with persistent atmospheric blocking, and an unusually northward jet stream location over Scandinavia.
C. E. Iles, R. Vautard, M. Vrac
doaj   +1 more source

The Tropical Challenge in Solar Energy Modelling: Spatial and Seasonal Breakdown of Semi-Empirical Approaches Under Topographic Heterogeneity

Earth
Accurate and spatially representative estimation of Global Horizontal Irradiance (GHI) is critical for solar energy planning in tropical regions characterized by strong atmospheric variability and complex topography.
Rifdah Octavi Azzahra, Afina Aristiani Zahra, Bintang Lamra Soetopo, Muhammad Dimyati, Iwa Garniwa, Hyunjin Lee, Josaphat Tetuko Sri Sumantyo, Pranda Mulya Putra Garniwa   +7 more
doaj   +1 more source

Atmospheric Shocks in Mira Variables — MgII Emission [PDF]

International Astronomical Union Colloquium, 1988
AbstractWe have undertaken an extensive program to investigate atmospheric shock dynamics in Mira variables through monitoring the MgII emission strengths versus phase. Theoretical calculations of Bowen (1987), which represent the structural variations in the extended atmosphere of a pulsating Mira, are presented in addition to the MgII observations ...
Edward W. Brugel, T.E. Beach, L.A. Willson, G.H. Bowen   +3 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Response of the Antarctic Circumpolar Current to Atmospheric Variability [PDF]

Journal of Climate, 2008
Abstract Historical hydrographic profiles, combined with recent Argo profiles, are used to obtain an estimate of the mean geostrophic circulation in the Southern Ocean. Thirteen years of altimetric sea level anomaly data are then added to reconstruct the time variable sea level, and this new dataset is analyzed to identify and monitor ...
Sallee, J.B., Morrow, R., Speer, K.
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Benchmarking Northern Hemisphere midlatitude atmospheric synoptic variability in centennial reanalysis and numerical simulations

Geophysical Research Letters, 2016
The representation of midlatitude winter atmospheric synoptic variability in centennial reanalysis products, which assimilate surface observations only, and atmospheric model simulations constrained by observation‐based data sets is assessed. Midlatitude
Alessandro Dell'Aquila, Susanna Corti, Antje Weisheimer, Hans Hersbach, Carol Peubey, Paul Poli, Paul Berrisford, Dick Dee, Adrian Simmons   +8 more
doaj   +1 more source