Results 61 to 70 of about 582,523 (269)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Neutronics/thermal-hydraulics coupling simulation using JAMPAN in a single BWR assembly
Mechanical Engineering JournalWe have aimed to realize high-fidelity neutronics/thermal-hydraulics coupling simulation to provide simulation results that can be used as validation data for reactor analysis codes.
Tomohiro KAMIYA +6 more
doaj +1 more source
Sub-barrier Fusion and Neutron Transfer with Positive Q-value
EPJ Web of Conferences, 2014 Fusion excitation functions of 16O+76Ge and 18O+74Ge have been measured with high precision at energies near and below the Coulomb barrier. Coupled-channels calculations including inelastic excitations well reproduce the experimental fusion excitation ...
Lin C. J. +8 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Evaluation of important phenomena through the PIRT process for a sodium fire event
Nihon Kikai Gakkai ronbunshu, 2020 Sodium fire is one of key issues in sodium-cooled fast reactor (SFR) plants. JAEA has developed sodium fire analysis codes, a zone model code SPHINCS and a field model code AQUA-SF, to evaluate the consequence of sodium fire events.
Mitsuhiro AOYAGI +5 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Design of the offline test electronics for the nozzle system of proton therapy
Scientific ReportsA set of nozzle equipment for proton therapy is currently under development at China Institute of Atomic Energy (CIAE). To facilitate the off-line commissioning of the whole equipment, a set of ionization chamber signal generation system, known as the ...
Peng Huang +10 more
doaj +1 more source