Results 41 to 50 of about 7,218 (260)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Qubit operations using a modular optical system engineered with PyOpticL: a code-to-CAD optical layout tool [PDF]

Quantum
Complex optical design is hindered by conventional piecewise setup, which prevents modularization and therefore abstraction of subsystems at the circuit level.
Jacob Myers, Christopher Caron, Nishat Helaly, Zhenyu Wei, Justin Oh, Zack Gotobed, Kotaro Yabe, Robert J. Niffenegger   +7 more
doaj   +1 more source

Optical Analogs of Rabi Splitting in Integrated Waveguide‐Coupled Resonators

Advanced Physics Research, 2023
Realizing optical analogs of quantum phenomena in atomic, molecular, or condensed matter physics has underpinned a range of photonic technologies. Rabi splitting is a quantum phenomenon induced by a strong interaction between two quantum states, and its ...
Hamed Arianfard, Jiayang Wu, Saulius Juodkazis, David J. Moss   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

High-contrast sub-Doppler absorption spikes in a hot atomic vapor cell exposed to a dual-frequency laser field

New Journal of Physics, 2017
The saturated absorption technique is an elegant method widely used in atomic and molecular physics for high-resolution spectroscopy, laser frequency standards and metrology purposes.
Moustafa Abdel Hafiz, Denis Brazhnikov, Grégoire Coget, Alexei Taichenachev, Valeriy Yudin, Emeric de Clercq, Rodolphe Boudot   +6 more
doaj   +1 more source

Extremely Nonlinear Optics Using Shaped Pulses Spectrally Broadened in an Argon- or Sulfur Hexafluoride-Filled Hollow-Core Fiber

Applied Sciences, 2015
In this contribution we present a comparison of the performance of spectrally broadened ultrashort pulses using a hollow-core fiber either filled with argon or sulfur hexafluoride (SF6) for demanding pulse-shaping experiments.
Andreas Hoffmann, Michael Zürch, Christian Spielmann   +2 more
doaj   +1 more source

An open source digital servo for atomic, molecular, and optical physics experiments [PDF]

Review of Scientific Instruments, 2015
We describe a general purpose digital servo optimized for feedback control of lasers in atomic, molecular, and optical physics experiments. The servo is capable of feedback bandwidths up to roughly 1 MHz (limited by the 320 ns total latency); loop filter shapes up to fifth order; multiple-input, multiple-output control; and automatic lock acquisition ...
D R, Leibrandt, J, Heidecker
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source