Results 51 to 60 of about 7,734 (310)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Optics and interferometry with atoms and molecules

, 2008
Interference with atomic and molecular matter waves is a rich branch of atomic physics and quantum optics. It started with atom diffraction from crystal surfaces and the separated oscillatory fields technique used in atomic clocks. Atom interferometry is
Schmiedmayer, Jorg, Cronin, Alexander D., Jörg Schmiedmayer, Pritchard, David E., David E. Pritchard, Alexander D. Cronin   +5 more
core   +1 more source

Qubit operations using a modular optical system engineered with PyOpticL: a code-to-CAD optical layout tool [PDF]

Quantum
Complex optical design is hindered by conventional piecewise setup, which prevents modularization and therefore abstraction of subsystems at the circuit level.
Jacob Myers, Christopher Caron, Nishat Helaly, Zhenyu Wei, Justin Oh, Zack Gotobed, Kotaro Yabe, Robert J. Niffenegger   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The virtual atomic and molecular data centre (VAMDC) consortium [PDF]

, 2016
The Virtual Atomic and Molecular Data Centre (VAMDC) Consortium is a worldwide consortium which federates atomic and molecular databases through an e-science infrastructure and an organisation to support this activity.
Tashkun, S., Stempels, E, Zeippen, C, Drouin, B. J., Tyuterev, V., Rhee, Y. J., Loboda, P.A., Babikov, Yu, Perevalov, V., Delahaye, F, Roueff, E., Ba, Y.A., Dimitrijević, M. S., Ba, Y. A, Dimitrijević, M., Ralchenko, Yu., Boudon, V., Heiter, U., Fazliev, A. Z., Quintas-Sánchez, E, Antony, B., Endres, C., PANCHESHNYI, Sergey, Piskunov, N., Rothman, L., Millar, T, Schlemmer, S., Rhee, Y.J., Ba, Y., Loboda, P. A., Jevremović, D, Piskunov, Nikolai, Gordon, I. E., Zeippen, C., Perevalov, V. I., Ba, YA, Tyuterev, Vl, Mihajlov, A, Babikov, Y.L., Palmeri, P., Mason, H., Drouin, B.,, Gordon, I., LETO, Giuseppe, Stempels, Eric H. C., Maclot, S., Postler, J, Zatsarinny, O., Krishnakumar, E, Millar, T. J., Rhee, Y., Drouin, B., J., Drouin, B., Rhee, Y-J., Gagarin, S., Zatsarinny, O, Doronin, M., Domaracka, A., Braams, BJ, Krishnakumar, E., Boudon, V, Gagarin, S, Walton, N, Mason, N. J., Ralchenko, Yu, Mulas, G., Vujčić, V, Loboda, P, Gagarin, S. V., Fazliev, A, Dimitrijevic, MS, Babikov, Yurii L., Mason, Nigel, Chung, H-K., Chung, H. -K., Hill, C., Gagarin, S.V., Braams, B., Quinet, P., Walton, N. A., et al., Rothman, L, Zwolf, C.M., Rhee, Y.-J., Marinkovic, B.P., Antony, BK, Markwick, A, Gratier, P., Wakelam, V., Babikov, Y., Zanna, G. Del, Leto, G., Del Zanna, G, Palmeri, P, Mendoza, C., Mihajlov, A.A., Pancheshnyi, S., Ryabchikova, T., de Urquijo, J., Zanna, G Del, Loboda, P., Mason, N.J., Gordon, I.E., Urquijo, J. De, Mihajlov, A., Marinković, B., Dimitrijevic, M.S., Gordon, I, Pakhomov, Yu., Pakhomov, Y., Mihajlov, A. A., Marinković, B. P., Moreau, N., Fazliev, A.Z., Joblin, C., Pancheshnyi, Sergey, V., Chung, H.-K., Delahaye, F., Braams, B. J., Walton, N.A., Walton, N., Urquijo, J De, Wakelam, V, Rothman, L.S., Antony, B.K., Domaracka, A, Marquart, Thomas, Chung, H., Dubernet, M. L., Rhee, Y-J, Fazliev, A., Dubernet, M.L., Antony, B, Tennyson, J., Stempels, E., Zwölf, C., Scheier, P., Mason, H. E., Bartschat, K., Markwick, A., Bartschat, K, Urquijo, J.D., Kasprzak, A., Ralchenko, Y., Drouin, B.J., VAMDC Consortium,, Hill, C, Rixon, G., Zwoelf, C. M., MULAS, Giacomo, Daniel, F, Zwölf, C. M., Babikov, Yu L., Chung, H-K, Zeippen, C. J., Pancheshnyi, V.I., Heiter, Ulrike, de Urquijo, J, Perevalov, V.I., Chung, K., Mason, N., Millar, T., Postler, J., Vujčić, V., Tyuterev, V.G., Jevremović, D., Daniel, F., Mason, H.E., Schmitt, B., Endres, C.P., Marquart, T., Quintas-Sánchez, E., Mason, H, Braams, B, Kasprzak, A, Sahal-Bréchot, S., Del Zanna, G., Mason, N, Dubernet, M., Marinković, B, Zanna, G.D., Zeippen, C.J., Pancheshnyi, Sergey,, Louge, T., Braams, B.J., Rothman, L. S., Antony, B. K., Babikov, Yu.L., Dubernet, ML, Babikov, Yu L, Rhee, Y. -J., Quinet, Pascal, Millar, T.J., Pakhomov, Yu, Endres, C. P., Tyuterev, Vl G., Ba, Y. A.   +196 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Extremely Nonlinear Optics Using Shaped Pulses Spectrally Broadened in an Argon- or Sulfur Hexafluoride-Filled Hollow-Core Fiber

Applied Sciences, 2015
In this contribution we present a comparison of the performance of spectrally broadened ultrashort pulses using a hollow-core fiber either filled with argon or sulfur hexafluoride (SF6) for demanding pulse-shaping experiments.
Andreas Hoffmann, Michael Zürch, Christian Spielmann   +2 more
doaj   +1 more source

Frustrated double ionization of atoms in circularly polarized laser fields

New Journal of Physics, 2021
We theoretically study frustrated double ionization (FDI) of atoms subjected to intense circularly polarized laser pulses using a three-dimensional classical model.
HuiPeng Kang, Shi Chen, Jing Chen, Gerhard G Paulus   +3 more
doaj   +1 more source

An open source digital servo for atomic, molecular, and optical physics experiments [PDF]

Review of Scientific Instruments, 2015
We describe a general purpose digital servo optimized for feedback control of lasers in atomic, molecular, and optical physics experiments. The servo is capable of feedback bandwidths up to roughly 1 MHz (limited by the 320 ns total latency); loop filter shapes up to fifth order; multiple-input, multiple-output control; and automatic lock acquisition ...
D R, Leibrandt, J, Heidecker
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source