Results 61 to 70 of about 100,070 (278)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Shrinking Atomic Clocks [PDF]

Science, 2013
Physics Atomic clocks housed in national laboratories around the world provide a precise time signal on which our present high-technology lives depend. Precise synchronization allows for colossal amounts of data to be reliably transferred around networks of optic fibers at ever-increasing rates, as well as providing accurate navigation systems.
openaire   +1 more source

Cold atom clocks and applications [PDF]

Journal of Physics B: Atomic, Molecular and Optical Physics, 2005
This paper describes advances in microwave frequency standards using laser-cooled atoms at BNM-SYRTE. First, recent improvements of the $^{133}$Cs and $^{87}$Rb atomic fountains are described. Thanks to the routine use of a cryogenic sapphire oscillator as an ultra-stable local frequency reference, a fountain frequency instability of $1.6\times 10^{-14}
Bize, Sébastien, Laurent, Philippe, Abgrall, Michel, Marion, Harold, Maksimovic, Ivan, Cacciapuoti, Luigi, Grünert, Jan, Vian, Céline, Pereira dos Santos, Franck, Rosenbusch, Peter, Lemonde, Pierre, Santarelli, Giorgio, Wolf, Peter, Clairon, André, Luiten, André N., Tobar, Michael E., Salomon, Christophe   +16 more
openaire   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Lattice-induced non-adiabatic frequency shifts in optical lattice clocks

, 2010
We consider the frequency shift in optical lattice clocks which arises from the coupling of the electronic motion to the atomic motion within the lattice.
C. E. Moore, K. Beloy
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Blackbody radiation shift in strontium lattice clocks revisited

Physical Review Research, 2021
We reevaluate the blackbody radiation (BBR) induced ac-Stark shift of the strontium clock transition (5s5p)^{3}P_{0}-(5s^{2})^{1}S_{0} at 698nm used as reference in optical lattice clocks and as secondary representation of the SI unit “second.” At room ...
Ch. Lisdat, S. Dörscher, I. Nosske, U. Sterr   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cold atom microwave clock based on intracavity cooling in China space station

npj Microgravity
Atomic clocks with higher frequency stability and accuracy than traditional space-borne atomic clocks are the cornerstone of long-term autonomous operation of space-time-frequency systems.
Siminda Deng, Wei Ren, Jingfeng Xiang, Jianbo Zhao, Lin Li, Di Zhang, JinYin Wan, Yanling Meng, XiaoJun Jiang, Tang Li, Liang Liu, Desheng Lü   +11 more
doaj   +1 more source