Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler +14 more
wiley +1 more source
Physics-informed deep learning for molecular solubility prediction: integrating thermodynamic constraints with neural network architectures. [PDF]
Amiri M.
europepmc +1 more source
In this work, we introduce ancillary‐ligand‐mediated growth control of ultrathin CsPbI3 PeNPLs to achieve highly uniform thickness and reduced agglomeration. Strong ancillary‐ligand coordination to the perovskite surface regulates nucleation and improves surface passivation, enabling color‐pure emission and preferentially oriented superlattices.
Jongbeom Kim +23 more
wiley +1 more source
A foundation machine learning potential with polarizable long-range interactions for materials modelling. [PDF]
Gao R +5 more
europepmc +1 more source
Giant Anisotropy and High Second‐Order Nonlinearity of 3R‐MoS2 for Multifunctional Photonics
Graphical abstract highlights, 3R‐polytype of MoS2 (3R‐MoS2) as a multifunctional photonic platform enabled by giant optical anisotropy and optical nonlinearities, demonstrating subdiffractional waveguiding, giant second‐harmonic (SH) generation, and high‐performance reflective polarization control.
Georgy Ermolaev +17 more
wiley +1 more source
Assessing graphite schist as a supplementary cementitious material in concrete for antifungal activity, strength, hydration, microstructure, and radiation shielding. [PDF]
Serry M +12 more
europepmc +1 more source
Selective methane (CH4) photooxidation emerges from architectural decoupling of activation and preservation. Programmable organic semiconductor frameworks spatially organize oxidative flux and intermediate residence, separating reaction zones from product domains to synchronize activation strength with stabilization and establish a selective oxidation ...
Minxian Zhang +5 more
wiley +1 more source
Integrated Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulations Accelerate the Discovery of Novel PDE1 Inhibitors with Potential for the Treatment of Idiopathic Pulmonary Fibrosis. [PDF]
Cai XL +6 more
europepmc +1 more source
Hybrid Amyloid–Boron Nitride Aerogels for Lightweight Sound Insulation
Amyloid fibrils template the mild formation of boron nitride–rich hybrid aerogels with hierarchical porosity, enhanced BN‐like ordering, and fibril‐reinforced mechanics. These ultralight materials combine thermal stability with strong sound absorption and transmission loss, offering a sustainable bio‐assisted route toward lightweight acoustic shields ...
Mohammad Peydayesh +8 more
wiley +1 more source

