Results 51 to 60 of about 7,213,834 (363)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

A brief investigation of the dose field virtual simulation tools for reactor decommissioning and preliminary design for the HWRR reactor in China [PDF]

Nuclear Energy and Technology
The calculation and visualization of the dose field in the decommissioning of nuclear facilities is one of the important functions of the decommissioning virtual simulation system.
Yaping Guo, Peng Nie, Ruizhi Li, Lijun Zhang, Xingwang Zhang, Ren Ren, Zelong Zhao   +6 more
doaj   +3 more sources

Generation of Ammonium Ions Products From Reaction Between Dimethylhydroxylamine and Metal Ions

He huaxue yu fangshe huaxue, 2022
The ammonium ions produced by the reactions of relatively excessive dimethylhydroxylamine(DMHAN) with Fe3+, Ce4+ and Pu4+ in dilute nitric acid solutions at room temperature were determined by ion chromatographic method.
LI Chuan-bo, WANG Bo, LOU Fu-yan, CHEN Hui, YANG Shu-ming, LI Xiang   +5 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Optimization in granulation conditions for adsorbent of extraction chromatography

Mechanical Engineering Journal
Japan Atomic Energy Agency has been working on development of extraction chromatography technology for recovery of trivalent minor actinides (MA(III): Am, Cm) from high-level radioactive waste generated in reprocessing of spent fuel.
Kenta HASEGAWA, Ichiro GOTO, Yasunori MIYAZAKI, Hiromu AMBAI, Sou WATANABE, Masayuki WATANABE, Yuichi SANO, Masayuki TAKEUCHI   +7 more
doaj   +1 more source

Analytical study of perforation damage in reinforced concrete slabs subjected to oblique impact by projectiles with different nose shapes

Mechanical Engineering Journal, 2020
Considerable research has been carried out to establish a rational assessment method for nuclear power plants against external projectile impact. Most of the empirical formulas have been proposed to quantitatively investigate local damage to reinforced ...
Zuoyi KANG, Yukihiko OKUDA, Akemi NISHIDA, Haruji TSUBOTA, Yinsheng LI   +4 more
doaj   +1 more source

Calibration Technology of Ionization Chamber Tritium Monitor

He huaxue yu fangshe huaxue, 2023
The ionization chamber tritium monitor is the most important online monitoring equipment for monitoring the concentration of tritium in the air. In order to solve the problem of quantity value transmission, the calibration technology of ionization ...
LI Ming, XU Li-jun, MAO Na-qing, YE Hong-sheng, LUO Rui, LIN Min   +5 more
doaj   +1 more source

Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.

Journal of Physical Chemistry B, 2009
We present a new continuum solvation model based on the quantum mechanical charge density of a solute molecule interacting with a continuum description of the solvent.
A. Marenich, C. Cramer, D. Truhlar
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source