Results 51 to 60 of about 7,380,852 (360)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Scientific Reports, 2022 Based on the standards of ISO11704-2018 and ASTM D7283-17, a method for simultaneous determination of gross alpha and gross beta activity concentrations in water by liquid scintillation counting (LSC) was established, which can be applied to various ...
Xiaoyun Li +6 more
doaj +1 more source
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
FEBS Letters, EarlyView.Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki +4 more
wiley +1 more source
Generation of Ammonium Ions Products From Reaction Between Dimethylhydroxylamine and Metal Ions
He huaxue yu fangshe huaxue, 2022 The ammonium ions produced by the reactions of relatively excessive dimethylhydroxylamine(DMHAN) with Fe3+, Ce4+ and Pu4+ in dilute nitric acid solutions at room temperature were determined by ion chromatographic method.
LI Chuan-bo +5 more
doaj +1 more source
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
Neutronics/thermal-hydraulics coupling simulation using JAMPAN in a single BWR assembly
Mechanical Engineering JournalWe have aimed to realize high-fidelity neutronics/thermal-hydraulics coupling simulation to provide simulation results that can be used as validation data for reactor analysis codes.
Tomohiro KAMIYA +6 more
doaj +1 more source
Calibration Technology of Ionization Chamber Tritium Monitor
He huaxue yu fangshe huaxue, 2023 The ionization chamber tritium monitor is the most important online monitoring equipment for monitoring the concentration of tritium in the air. In order to solve the problem of quantity value transmission, the calibration technology of ionization ...
LI Ming +5 more
doaj +1 more source
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source