Results 61 to 70 of about 3,279,575 (293)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A New Method for Characterization of Natural Zeolites and Organic Nanostructure using Atomic Force Microscopy [PDF]
, 2012 In order to study and develop an economic solution to environmental pollution in water, a wide variety of materials were investigated. Natural zeolites emerge from that research as the best in class of this category.
Domenico P. R. O. F. Fuoco
core
Charge storage in mesoscopic graphitic islands fabricated using AFM bias lithography [PDF]
, 2011 Electrochemical oxidation and etching of highly oriented pyrolytic graphite (HOPG) has been achieved using biased atomic force microscopy (AFM) lithography, allowing patterns of varying complexity to be written into the top layers of HOPG.
G U Kulkarni +11 more
core +1 more source
Experimental Nanomechanics. Atomic Force Microscopy Methods
Механика машин, механизмов и материалов, 2008 Considered are atomic force microscopy methods concerning problems of experimental nanomechanics targeted on estimation of physical and mechanical properties of materials in nanovolumes and thin surface layers.
S.A. Chizhik
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A simple method for the determination of qPlus sensor spring constants
Beilstein Journal of Nanotechnology, 2015 qPlus sensors are widely used to measure forces at the atomic scale, however, confidence in these measurements is limited by inconsistent reports of the spring constant of the sensor and complications from finite tip heights.
John Melcher +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Determination of cellular strains by combined atomic force microscopy and finite element modeling [PDF]
, 2002 Many organs adapt to their mechanical environment as a result of physiological change or disease. Cells are both the detectors and effectors of this process.
Charras, GT +3 more
core +1 more source
Atomic force microscopy in ophthalmic surgery
4th IEEE Conference on Nanotechnology, 2004., 2005 Refractive errors are some of the most common ophthalmic abnormalities. The introduction of excimer laser technology in refractive corneal surgery aims to eliminate all or the major part of the first corneal surface optical aberrations through the modelling of the corneal surface.
MP De Santo +4 more
openaire +4 more sources