Results 111 to 120 of about 1,352,213 (332)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Surface modes of ultracold atomic clouds with a very large number of vortices [PDF]

, 2003
Miguel A. Cazalilla
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

The quantum measurement effect of interaction without interaction for an atomic beam

Results in Physics, 2017
When an atomic beam collectively and harmonically vibrates perpendicular to the wave vector of the beam, the number of atoms reaching the atomic detector will have a vibrant factor Δt/T if the measurement time interval Δt is shorter than the period T ...
Yong-Yi Huang
doaj   +1 more source

Note on Atomic Numbers and Mass Numbers

NIPPON KAGAKU KAISHI, 1972
Atomic masses (A) of the most stable nuclides are generally led by linear summations of a pair of proton and neutron (p - n) for nuclides whose atomic numbers (Z) are below 30 and p - n n for those above 30Z nuclides. Binding energies (b. e.) are calculated in conformity of it, and additions of 4b. e.14Z to b. e.
Ryoichi MIYAKE, Hisa YATIMA
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Comprehensive study of photon and proton interactions to interpret the radiation parameters of boron derivative drugs for chemoradiotherapy

Journal of Nigerian Society of Physical Sciences
 For chemoradiotherapy applications, this work investigated the photon and proton interaction parameters in five boron-based medications: sodium borocaptate, bortezomib, delanzomib, boronophenylalanine, and boric acid. Photon interaction parameters such
A. M. Olaosun, C. A. Aborisade, D. E. Shian, P. T. Osuolale   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characteristic frequency and atomic number [PDF]

Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character, 1917
Recent work on the specific heat of chemical elements in the solid state has led to important conclusions with regard to the values of the atomic heat at constant volume. The curves showing the variation of atomic heat with temperature are all of the same form, and any given curve can be transformed into any other merely by altering the ...
openaire   +1 more source