Results 71 to 80 of about 15,716 (302)
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
The Negativity of Negative Propositions [PDF]
, 2012 The problem of truthmakers for negative propositions was introduced by Bertrand Russell in 1918. Since then the debate has mostly been concerned with whether to accept or reject their existence, and little has been said about what it is that makes a ...
Kühl, Carl Erik
core +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Borders of a Game: Analysis of the Practical Phenomenology and Other Trends of Nowadays
Vilnius University Open Series, 2020 This article, through a prism of reduction, focuses on the gaming of practical phenomenology (M. van Manen), logical atomism (L. Wittgenstein), rhizomatic movement (Deleuze) as well as anthropocene moods in the playground of the education science.
Viktorija Voidogaitė
doaj +1 more source
The Content and Acquisition of Lexical Concepts [PDF]
, 2006 This thesis aims to develop a psychologically plausible account of concepts by integrating key insights from philosophy (on the metaphysical basis for concept possession) and psychology (on the mechanisms underlying concept acquisition).
Horsey, Richard
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
The Cosmos as a World City: A Hylomorphic Foundation for Civic Renewal
ReligionsThis paper contends that the West’s civic crisis is, at root, a cosmological crisis: civic renewal requires metaphysical repair. It is insufficient to endorse virtue ethics and demand civic virtues without a deeper account of reality that can sustain ...
William M. R. Simpson
doaj +1 more source
Deleuze and Epicurean Philosophy: Atomic Speed and Swerve Speed
Journal of French and Francophone Philosophy, 2013 This paper reconstructs Gilles Deleuze’s interpretation of Epicurean atomism, and explicates his claim that it represents a problematic idea, similar to the idea exemplified in early, “barbaric” accounts of the differential calculus.
Michael James Bennett
doaj +1 more source