Results 61 to 70 of about 15,716 (302)
KANT AND THE «SPIRIT OF EPICURUS» (IN KANT’S PRE-CRITICAL AND CRITICAL PHILOSOPHY)
Концепт: философия, религия, культура, 2018 In the first part of the article, the relation of the ethics of Epicurus to Kant's practical philosophy is considered. Analyzing the principles on which the notion of the supreme good of the ancients was built, Kant paid special attention to the ...
V. A. Ter-Arakeliantz, A. V. Yukhno
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
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Mechanistic Trends in Chemistry
Substantia, 2018 During the twentieth century, the mechanistic worldview came under attack mainly because of the rise of quantum mechanics but some of its basic characteristics survived and are still evident within current science in some form or other.
Louis Caruana SJ
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
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Lucretius' arguments on the swerve and free-action [PDF]
, 2019 In his version of atomism, Lucretius made explicit reference to the concept of an intrinsic declination of the atom, the atomic swerve (clinamen in Latin), stressing that the time and space of the infinitesimal atomic vibration is uncertain. The topic of
Evangelidis, Basil
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
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Čaro a pád logického atomizmu (Glamour and Comedown of Logical Atomism)
Ostium, 2008 This article discuss the theory presented by B. Russell and L. Wittgenstein, named logical atomism, which is one of the most interesting and fundamental theories of modern logical analysis of language.
Vladimíra Vitálošová
doaj
Kaila's Reception of Hume [PDF]
, 2012 In this paper, I discuss Eino Kaila's (1890-1958) understanding of David Hume. Kaila was one of the leading Finnish philosophers of the 20th century and a correspondent of the Vienna Circle.
Hakkarainen, Jani
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