Results 61 to 70 of about 3,060 (242)
Epistemology of a Believer: Making Sense of Duhem’s Anti-Atomism [PDF]
, 2012 Pierre Duhem's (1861–1916) lifelong opposition to 19th century atomic theories of matter has been traditionally attributed to his conventionalist and/or positivist philosophy of science.
kchoko@indiana.edu, Klodian Coko
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
, 2004 Atomism is defined as the view that the moral value of any object is ultimately determined by simple features whose contribution to the value of an object is always the same, independently of context. A morally fundamental feature, in a given context, is
Lund University., Alm, David,
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Aristotle: Critic or Pioneer of Atomism? [PDF]
, 2007 Aristotle is typically construed as a critic of atomism. He was indeed a critic of atomism of the extreme kind formulated by Democritus, according to which bulk matter is made of nothing other than unchangeable pieces of universal matter possessing shape
Chalmers, Alan F
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The Cosmos as a World City: A Hylomorphic Foundation for Civic Renewal
ReligionsThis paper contends that the West’s civic crisis is, at root, a cosmological crisis: civic renewal requires metaphysical repair. It is insufficient to endorse virtue ethics and demand civic virtues without a deeper account of reality that can sustain ...
William M. R. Simpson
doaj +1 more source
Russell’s Logical Atomism and Modality
This chapter concerns the nature of Russell’s logical atomism and its relation to modality. After noting the significance of Russell’s logical atomism (§1), the author reviews the standard interpretation of logical atomism as a search for logical atoms (§
Landon D. C. Elkind
core +1 more source