Results 41 to 50 of about 568 (267)
Controvérsias sobre o atomismo no século XIX Controversies on atomism in the nineteenth century
Química Nova, 2009 The present article reviews aspects of the controversy in nineteenth-century physical sciences between atomists and anti-atomists, and the scientific, philosophical and methodological aspects about the atomic debates.
Maria da Conceição Marinho Oki
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FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
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Les Dossiers du GRIHL, 2010 Anna Rita Capoccia's contribution is based on the analysis of manuscripts created by Giulio Gori and other Jesuit professors at Roman College in the first twenty years of eighteenth century.There are here described professors' "hidden" opposition to ...
Anna Rita Capoccia
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
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KANT AND THE «SPIRIT OF EPICURUS» (IN KANT’S PRE-CRITICAL AND CRITICAL PHILOSOPHY)
Концепт: философия, религия, культура, 2018 In the first part of the article, the relation of the ethics of Epicurus to Kant's practical philosophy is considered. Analyzing the principles on which the notion of the supreme good of the ancients was built, Kant paid special attention to the ...
V. A. Ter-Arakeliantz, A. V. Yukhno
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FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
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Mechanistic Trends in Chemistry
Substantia, 2018 During the twentieth century, the mechanistic worldview came under attack mainly because of the rise of quantum mechanics but some of its basic characteristics survived and are still evident within current science in some form or other.
Louis Caruana SJ
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
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