Results 241 to 250 of about 224,178 (338)

Hydrogel microwells with customizable bottom design: A one‐step approach to spheroid formation

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Abstract Conical microwells featuring a variety of bottom‐shape features have received increased recognition because of their enhanced surface characteristics that improve the in vitro‐in vivo correlation in a wide range of biological applications, such as in three‐dimensional cell culture models, specifically cell spheroidal formation, and drug ...
Ahmad A. Manzoor   +5 more
wiley   +1 more source

Diet Diversity and Adherence to a Mediterranean Diet Pattern in Pregnancy Is Protective Against the Development of Early-Childhood Atopic Dermatitis. [PDF]

open access: yesNutrients
Heye KN   +11 more
europepmc   +1 more source

Overexpressed Palladin Rescues Enteropathogenic E. coli (EPEC) Pedestal Lengths in ArpC2 Depleted Cells

open access: yesCytoskeleton, EarlyView.
ABSTRACT Enteropathogenic Escherichia coli (EPEC) causes diarrheal disease. Once ingested, these extracellular pathogens attach to the intestinal epithelial cells of their host, collapse the localized microvilli, and generate actin‐rich structures within the host cells that are located beneath the attached bacteria, called “pedestals.” Palladin is an ...
Kaitlin M. Bruzzini   +2 more
wiley   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano   +8 more
wiley   +1 more source

Impact of First‐of‐Its‐Kind Patient‐Facing Pharmacogenetics Tool on Dosing Decisions and Treatment Outcomes

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Germline pharmacogenetics (PGx) is increasingly used to tailor medication selection/dosing. However, existing systems primarily communicate PGx results to providers, limiting direct patient engagement. To address this, we developed YourPGx Oncology, an innovative patient‐facing portal that delivers multi‐gene PGx results (CYP2D6, UGT1A1, DPYD) through ...
Youngwoo Cho   +15 more
wiley   +1 more source

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