Results 11 to 20 of about 337,302 (383)

Atopic dermatitis.

Acta bio-medica : Atenei Parmensis, 2020
Atopic dermatitis (AD) is a common inflammatory skin disease, clinically characterized by recurrent eczematous lesions and intense itching, leading to excoriations and susceptibility to cutaneous infections. Although it is considered a pediatric disorder, mainly starting in infancy, it is also very common in adults.
Elena Galli, Bianca Cinicola, Rossella Carello, Silvia Caimmi, Giulia Brindisi, Giovanna De Castro, Anna Maria Zicari, Maria Angela Tosca, Sara Manti, Alberto Martelli, Mauro Calvani, Claudio Cravidi, Gian Luigi Marseglia, Fabio Cardinale, Michele Miraglia del Giudice, Carlo Caffarelli, Marzia Duse   +16 more
semanticscholar   +6 more sources

Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

Nature reviews. Drug discovery, 2021
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains challenging to treat owing to the limited response to available therapies.
T. Bieber
semanticscholar   +1 more source

Molecular Mechanisms of Atopic Dermatitis Pathogenesis

International Journal of Molecular Sciences, 2021
Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic feature is persistent itching of the skin. The chronic, relapsing course of the disease, economic burden, and the whole family’s involvement in the treatment process ...
Jowita Sroka-Tomaszewska, M. Trzeciak
semanticscholar   +1 more source

Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis

JAMA dermatology, 2022
This analysis of 2 randomized clinical trials evaluates long-term (52 weeks) efficacy and safety of upadacitinib treatment in patients with atopic dermatitis.
E. Simpson, K. Papp, A. Blauvelt, C. Chu, H. Hong, N. Katoh, B. Calimlim, J. Thyssen, A. Chiou, R. Bissonnette, L. S. Stein Gold, C. Wegzyn, Xiaofei Hu, Meng Liu, John Liu, A. Tenorio, A. Chu, E. Guttman‐Yassky   +17 more
semanticscholar   +1 more source

Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis.

New England Journal of Medicine, 2021
BACKGROUND The oral Janus kinase 1 (JAK1) inhibitor abrocitinib, which reduces interleukin-4 and interleukin-13 signaling, is being investigated for the treatment of atopic dermatitis. Data from trials comparing JAK1 inhibitors with monoclonal antibodies,
T. Bieber, E. Simpson, J. Silverberg, D. Thaçi, C. Paul, A. Pink, Y. Kataoka, C. Chu, M. Dibonaventura, R. Rojo, J. Antinew, I. Ionita, R. Sinclair, S. Forman, Jacek Zdybski, P. Biswas, B. Malhotra, Fan Zhang, H. Valdez   +18 more
semanticscholar   +1 more source

Prevalence of Isotretinoin Therapy in Adolescents and Young Adults With and Without Atopic Dermatitis: A Nationwide Prescription-based Population Study

Acta Dermato-Venereologica, 2023
Although isotretinoin has anti-inflammatory and immunomodulatory properties, it can exacerbate atopic dermatitis. National estimates of the extent to which patients with atopic dermatitis are affected by severe acne and isotretinoin tolerability are ...
Cathrine H. Mohn, Hege S. Blix, Anja Maria Brænd, Per Nafstad, Jon Anders Halvorsen   +4 more
doaj   +1 more source

Tralokinumab for moderate‐to‐severe atopic dermatitis: results from two 52‐week, randomized, double‐blind, multicentre, placebo‐controlled phase III trials (ECZTRA 1 and ECZTRA 2)*

British Journal of Dermatology, 2020
Tralokinumab, a fully human monoclonal antibody, specifically neutralizes interleukin‐13, a key cytokine driving peripheral inflammation in atopic dermatitis (AD). In phase II studies, tralokinumab combined with topical corticosteroids provided early and
A. Wollenberg, A. Blauvelt, E. Guttman‐Yassky, M. Worm, C. Lynde, J. Lacour, L. Spelman, N. Katoh, H. Saeki, Yves Poulin, A. Lesiak, L. Kircik, S. H. Cho, P. Herranz, M. Cork, Ketty Peris, L. Steffensen, B. Bang, A. Kuznetsova, T. N. Jensen, M. L. Østerdal, E. Simpson   +21 more
semanticscholar   +1 more source

Prevalence and Incidence of Atopic Dermatitis: A Systematic Review

Acta Dermato-Venereologica, 2020
The primary objective of this study was to systematically review and analyse epidemiological studies of the prevalence and incidence of atopic dermatitis (AD) during childhood and adulthood, focusing on data from the 21st century.
Simon B A Bylund, L. V. von Kobyletzki, Marika Svalstedt, Å. Svensson   +3 more
semanticscholar   +1 more source

ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children

Journal of the European Academy of Dermatology and Venereology, 2020
Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease. The diagnosis is made using evaluated clinical criteria. Disease activity and burden are best measured with a composite score, assessing both objective and subjective ...
A. Wollenberg, S. Christen-Zäch, Alain Taïeb, Carle Paul, J. P. Thyssen, M. Bruin-Weller, C. Vestergaard, J. Seneschal, T. Werfel, M. Cork, B. Kunz, R. Fölster-Holst, M. Trzeciak, U. Darsow, Z. Szalai, M. Deleuran, L. Kobyletzki, L. Kobyletzki, S. Barbarot, A. Heratizadeh, U. Gieler, D. Hijnen, S. Weidinger, L. Raeve, Å. Svensson, D. Simon, J. Stalder, J. Ring   +27 more
semanticscholar   +1 more source

Impact of Atopic Dermatitis on Work and Activity Impairment in Taiwan

Acta Dermato-Venereologica, 2021
Atopic dermatitis has a substantial impact on work and activity impairment according to studies from Western communities. Prospective studies of work productivity and activity impairment in Asian patients with atopic dermatitis are lacking.
Tom C. Chan, Yi-Chun Lin, Yung-Tsu Cho, Chao-Hsiun Tang, Chia-Yu Chu   +4 more
doaj   +1 more source