Results 91 to 100 of about 65,367 (309)
PLoS ONE, 2020 IntroductionExisting evidence on the relationship between childhood lower respiratory tract infections (LRTI) and the subsequent atopy development is controversial. We aimed to investigate an association between viral LRTI at 2 years.MethodsWe conducted
Sebastien Kenmoe +4 more
doaj +1 more source
Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma
Allergy, EarlyView.Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong +217 more
wiley +1 more source
Allergic disorders: A model for establishing how to prevent commondisease
Allergology International, 2004 Allergy to common agents, such as plant pollens, dust mites and foods, is termed atopy. Atopy is the principal cause of the chronic inflammatory diseases of eczema (the skin), hayfever (the nose) and asthma (the lungs) in children and young adults. Atopy
Akiko Yamasaki +6 more
doaj +1 more source
The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health
Allergy, EarlyView.This study evaluates the association of the nasal microbiome with air pollutants, meteorological conditions, and respiratory health in adolescents. Bacterial diversity is positively associated with hay fever and short‐term NO2 exposure, and negatively with temperature. A Moraxella‐dominated nasotype is linked to lower O3 exposure and higher temperature
Javier Perez‐Garcia +11 more
wiley +1 more source
BMC Medical Genetics, 2009 Background Asthma and atopy are complex phenotypes with shared genetic component. In this study we attempt to identify genes related to these traits performing a two-stage DNA pooling genome-wide analysis in order to reduce costs.
Kogevinas Manolis +9 more
doaj +1 more source
An international prospective general population-based study of respiratory work disability [PDF]
, 2009 Background: Previous cross-sectional studies have shown that job change due to breathing problems at the workplace (respiratory work disability) is common among adults of working age.
Antó, J.M. +11 more
core +1 more source
Mediation of Polygenic Asthma Risk Through Gene Expression
Allergy, EarlyView.We apply published PRSs in African‐ancestry individuals and quantify the extent to which the PRS‐asthma relationship is mediated by clinical biomarkers and gene‐expression signatures of asthma. We found the best PRS to be the one derived using the largest sample size and including African‐ancestry individuals.
Rakesh Natarajan +29 more
wiley +1 more source
Wildfires and Atopic Diseases: A Review
Allergy, EarlyView.ABSTRACT Wildfire smoke is a major environmental health threat that has increased in frequency and severity in recent years. A hazardous component of wildfire smoke is particulate matter ≤ 2.5 μm (PM2.5). There is evidence to suggest that exposure to wildfire PM2.5 may increase the risk of developing or exacerbating atopic diseases, such as asthma ...
Alex Ha, John R. Balmes, Maria L. Wei
wiley +1 more source
Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes
Communications BiologyImmunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a ...
Takao Hirano +6 more
doaj +1 more source