Results 41 to 50 of about 42,157 (238)

Neuronal substance P-driven MRGPRX2-dependent mast cell degranulation products differentially promote vascular permeability

Frontiers in Immunology
Mas-related G protein-coupled receptor b2 (Mrgprb2) binding to its cationic endogenous and exogenous ligands induces mast cell degranulation and promotes inflammation in mice. However, the physiological roles of its human homologue MRGPRX2 remain unclear.
Masakazu Nagamine, Masakazu Nagamine, Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akihisa Yoshikawa, Akihisa Yoshikawa, Masahiro Nakamura, Akie Maehara, Risa Yamamoto, Yoko Okamoto, Hexing Wang, Hexing Wang, Hiromichi Yamada, Hiromichi Yamada, Keiko Maeda, Keiko Maeda, Nobuhiro Nakano, Toshiaki Shimizu, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Jiro Kitaura, Jiro Kitaura   +23 more
doaj   +1 more source

Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice

Allergology International, 2016
Background: Patients with house dust mite (HDM) allergy or Ascariasis produce serum IgE specific to the antigens of HDM or nematode Ascaris, respectively.
Mayu Suzuki, Mutsuko Hara, Saori Ichikawa, Seiji Kamijo, Takuya Nakazawa, Hideki Hatanaka, Kazuo Akiyama, Hideoki Ogawa, Ko Okumura, Toshiro Takai   +9 more
doaj   +1 more source

Refractory Eczema as a Presenting Feature of Common Variable Immunodeficiency

JEADV Clinical Practice, EarlyView.
ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic inborn error of immunity (IEI) in adults. It presents with recurrent infections and non‐infectious complications, including autoimmunity, lymphoproliferation and dermatitis.
Mercedes Sanchez‐Diaz, Lars Matthies, Andrea Vanegas Ramirez   +2 more
wiley   +1 more source

Gene–Environment Interactions—What Can These Tell Us about the Relationship between Asthma and Allergy?

Frontiers in Pediatrics, 2017
Asthma is a common condition, which is associated with atopy and allergic conditions including hay fever, eczema, and food allergies. Asthma and atopy are both complex conditions where genetic and environmental factors are implicated in causation ...
Steve Turner
doaj   +1 more source

DERMACLEAR: AI‐Powered Insights Into Four Chronic Inflammatory Skin Diseases in Spain

JEADV Clinical Practice, EarlyView.
Using an AI‐enhanced analysis of electronic health records from nearly 50,000 patients, the DERMACLEAR study provides real‐world insights into the prevalence, clinical complexity, comorbidities and treatment patterns of HS, CU, PsO and AD in Spain.
Ana Giménez‐Arnau, Javier Ortiz de Frutos, Raquel Rivera‐Díaz, Lluís Puig, Jaume Notario Rosa, José Luis López‐Estebaranz, Vicente García‐Patos Briones, Ana Martín‐Santiago, José Ignacio Rojo‐Laguna, Elisabet Fernández‐Martínez, Lara Gómez‐Labrador, Esteban Daudén   +11 more
wiley   +1 more source

Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

Scientific Reports, 2017
Sepsis is a serious clinical problem. Negative regulation of innate immunity is associated with sepsis progression, but the underlying mechanisms remains unclear. Here we show that the receptor CD300f promotes disease progression in sepsis.
Kumi Izawa, Akie Maehara, Masamichi Isobe, Yuka Yasuda, Makoto Urai, Yasutaka Hoshino, Keigo Ueno, Toshihiro Matsukawa, Mariko Takahashi, Ayako Kaitani, Emiko Shiba, Ayako Takamori, Shino Uchida, Koichiro Uchida, Keiko Maeda, Nobuhiro Nakano, Yoshinori Yamanishi, Toshihiko Oki, David Voehringer, Axel Roers, Susumu Nakae, Junko Ishikawa, Yuki Kinjo, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Toshio Kitamura, Jiro Kitaura   +27 more
doaj   +1 more source

Successful Treatment of Refractory Lichen Amyloidosus With Dupilumab

JEADV Clinical Practice, EarlyView.
ABSTRACT Lichen amyloidosis (LA) is a chronic, pruritic dermatosis with papillary dermal amyloid deposition. Standard therapies often fail, and most reports of dupilumab in LA involve patients with concomitant atopic dermatitis. We report a 32‐year‐old man with refractory, non‐atopic LA who had failed topical corticosteroids, tacrolimus, phototherapy ...
Sohrab Elahwiesy, Franziska Jochims, Manfred Kunz, Susann Forkel, Jan‐Christoph Simon, Benjamin Klein   +5 more
wiley   +1 more source

The interaction between the skin microbiome and antimicrobial peptides within the epidermal immune microenvironment: Bridging insights into atopic dermatitis

Allergology International
The epidermal immune microenvironment is a multifaceted system in which the interplay between the skin microbiome and antimicrobial peptides plays a pivotal role in sustaining skin homeostasis and preventing dysbiosis.
Shan Wang, Ge Peng, Alafate Abudouwanli, Mengyao Yang, Quan Sun, Wanchen Zhao, Arisa Ikeda, Yi Tan, Lin Ma, Hideoki Ogawa, Ko Okumura, François Niyonsaba   +11 more
doaj   +1 more source

Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response

Allergology International, 2017
Background: Interleukin-33 (IL-33) is an alarmin cytokine that binds to the interleukin 1 receptor-like 1 protein ST2. Clock is a key circadian gene that is essential for endogenous clockworks in mammals.
Takahiro Kawauchi, Kayoko Ishimaru, Yuki Nakamura, Nobuhiro Nakano, Mutsuko Hara, Hideoki Ogawa, Ko Okumura, Shigenobu Shibata, Atsuhito Nakao   +8 more
doaj   +1 more source

Bevacizumab‐Associated Eczema Herpeticum in Metastatic Ovarian Carcinoma: A Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Eczema herpeticum (EH) is a rare but potentially life‐threatening cutaneous infection caused by herpes simplex virus (HSV), classically associated with atopic dermatitis. Its occurrence in oncology patients receiving anti‐angiogenic targeted therapy and cytotoxic chemotherapy is exceedingly uncommon.
Mandeep Dutta Joshi, Nishant Pandey, Sushan Ghimire, Avilasha Shah, Anurag Tiwari, Salina Subedi, Deepika Neupane   +6 more
wiley   +1 more source