Results 111 to 120 of about 156,745 (364)

Detergent-free purification of ABC (ATP-binding-cassette) transporters [PDF]

Biochemical Journal, 2014
ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these proteins is often hampered by their large size and membrane location. Membrane protein purification usually utilizes detergents to solubilize the protein from the membrane, effectively removing ...
Gulati, S., Jamshad, M., Knowles, T.J., Morrison, K.A., Downing, R., Cant, N., Collins, R., Koenderink, J.B., Koenderink, J.B., Ford, R.C., Overduin, M., Kerr, I.D., Dafforn, T.R., Rothnie, A.J.   +13 more
openaire   +3 more sources

Toward Determining ATPase Mechanism in ABC Transporters: Development of the Reaction Path–Force Matching QM/MM Method [PDF]

, 2016
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are ubiquitous ATP-dependent membrane proteins involved in translocations of a wide variety of substrates across cellular membranes.
Arantes, Arkin-Ojo, Atwell, Borst, Brooks, Brooks, Car, Carroll, Chen, Csanyi, Davidson, Davidson, Davidson, Dewar, Doemer, E, Ercolessi, Fukui, Gao, Garcia-Viloca, Geourjon, Gonzalez-Lafont, Hehre, Holland, Hollenstein, Izvekov, Izvekov, Janas, Jones, Kamerlin, Khan, Khare, Klahn, Knight, Kumar, Laio, Li, Lopez, MacKerell, MacKerell, Maragliano, Maurer, Miertus, Mo, Moradi, Nam, Newstead, Nikaido, Oldham, Oldham, Oloo, Oswald, Parr, Plotnikov, Plotnikov, Pople, Poulsen, Procko, Pu, Rees, Roothaan, Rosta, Rudack, Schlegel, Schmitt, Schneider, Senior, Shao, Sharma, Shyamala, Stewart, Story, Tal, Thiel, Thiel, Torrier, Urbatsch, Warshel, Wen, Weng, Zaitseva, Zaitseva, Zaitseva, Zaitseva, Zhou, Zhou, Zoghbi   +86 more
core   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, EarlyView.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

Deciphering the functional role of clinical mutations in ABCB1, ABCC1, and ABCG2 ABC transporters in endometrial cancer

Frontiers in Pharmacology
ATP-binding cassette transporters represent a superfamily of dynamic membrane-based proteins with diverse yet common functions such as use of ATP hydrolysis to efflux substrates across cellular membranes.
Aayushi Gupta, Manu Smriti Singh, Manu Smriti Singh, Bipin Singh   +3 more
doaj   +1 more source

An Exploration of Advanced X-Divertors on ITER [PDF]

, 2013
It is found that the X-Divertor (XD) configuration [1-3] can be made with the conventional PF coil set on ITER[4], where all PF coils are outside the TF coils. Desirable configurations are possible where the PF currents are below the present maximum design limits on ITER, and where the baseline divertor cassette is used.
arxiv   +1 more source

Electron Transfer Precedes ATP Hydrolysis during Nitrogenase Catalysis [PDF]

, 2013
The biological reduction of N2 to NH3 catalyzed by Mo-dependent nitrogenase requires at least eight rounds of a complex cycle of events associated with ATP-driven electron transfer (ET) from the Fe protein to the catalytic MoFe protein, with each ET ...
Antony, Edwin, Danyal, Karamatullah, Dean, Dennis R., Duval, Simon, Hoffman, Brian M., Lytle, Anna K., Seefeldt, Lance C., Shaw, Sudipta   +7 more
core   +2 more sources

UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification

Advanced Science, EarlyView.
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia, He Zhang, Dingqiang Mo, Bo Xie, Hongdou Qiao, Tao Chen, Haoyue Song, Xinxin Xu, Sheng Yang   +8 more
wiley   +1 more source

EEG-NeXt: A Modernized ConvNet for The Classification of Cognitive Activity from EEG [PDF]

arXiv, 2022
One of the main challenges in electroencephalogram (EEG) based brain-computer interface (BCI) systems is learning the subject/session invariant features to classify cognitive activities within an end-to-end discriminative setting. We propose a novel end-to-end machine learning pipeline, EEG-NeXt, which facilitates transfer learning by: i) aligning the ...
arxiv  

The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 (StarD3/MLN64) in BRIN-BD11 insulinoma cells [PDF]

, 2016
No abstract ...
Borges Pinto, Joana, Graham, Annette
core   +4 more sources

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source