Results 91 to 100 of about 50,926 (288)

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters

, 2001
The 70-kDa peroxisomal membrane protein (PMP70) and the adrenoleukodystrophy protein (ALDP) are half ATP binding cassette (ABC) transporters in the peroxisome membrane.
Roerig, P, Mayerhofer, P, Gartner, J, Holzinger, A   +3 more
core   +2 more sources

Deciphering the functional role of clinical mutations in ABCB1, ABCC1, and ABCG2 ABC transporters in endometrial cancer

Frontiers in Pharmacology
ATP-binding cassette transporters represent a superfamily of dynamic membrane-based proteins with diverse yet common functions such as use of ATP hydrolysis to efflux substrates across cellular membranes.
Aayushi Gupta, Manu Smriti Singh, Manu Smriti Singh, Bipin Singh   +3 more
doaj   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source

Insect ATP-Binding Cassette (ABC) Transporters: Roles in Xenobiotic Detoxification and Bt Insecticidal Activity

, 2019
ATP-binding cassette (ABC) transporters, a large class of transmembrane proteins, are widely found in organisms and play an important role in the transport of xenobiotics.
Kaiyu Liu, Yutao Xiao, Swapan Chakrabarty, Minghui Jin, Chao Wu   +4 more
core   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Functional Analysis of Detergent‐Solubilized and Membrane‐Reconstituted ATP‐Binding Cassette Transporters [PDF]

, 2005
ATP‐binding cassette (ABC) transporters are vital to any living system and are involved in the translocation of a wide variety of substances, from ions and nutrients to high molecular weight proteins.
Konings, Wil N., Geertsma, Eric R., Doeven, Mark K., Rees, Douglas C., Biemans‐Oldehinkel, Esther, Poolman, Bert   +5 more
core   +4 more sources

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter

Nature Communications
ATP-binding cassette (ABC) transporters use ATP to transport substrates across membranes. In type IV ABC transporters, which include many multidrug resistance (MDR) pumps, communication between nucleotide-binding domains (NBDs) and transmembrane domains (
Victor Hugo Pérez Carrillo, Margot Di Cesare, Dania Rose-Sperling, Waqas Javed, Hannes Neuweiler, Julien Marcoux, Cédric Orelle, Jean-Michel Jault, Ute A. Hellmich   +8 more
doaj   +1 more source

Harlequin Ichthyosis: Case Report

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2019
Harlequin ichthyosis is a rare autosomal recessive congenital disease in which neonates present generalized hyperkeratotic plaques and deep fissures, ectropion, eclabium, malformation of the auricular pavilion and typical facies.
Patrícia A. Couto, Marcela C. Pastore, Jessica C. N. Araújo, Cecilya M. Mota, Caroline A. R. Chirano, Valeria K. A. Ferreira, Sidharta Q. Gadelha, Elaine D. Melo, Patricia C. B. de Melo, Luciana M. Santos   +9 more
doaj   +1 more source