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Critical roles of Hedgehog signaling pathway in regulating the multidrug resistance of ovarian cancer [PDF]
Journal of Ovarian ResearchOvarian cancer (OC) is a life-threatening disease with high morbidity and mortality rates among women. Treatment inevitably requires the use of multiple drugs, including platinum-based agents, taxanes, and targeted therapies, across all stages and ...
Ruixue Bi +9 more
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Tazobactam selects for multidrug resistance [PDF]
npj Antimicrobials and ResistancePiperacillin-Tazobactam is a β-lactam/β-lactamase inhibitor combination that is amongst the most prescribed antimicrobials in hospital medicine.
Emma R. Holden +4 more
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Annals of Medicine, 1991 Resistance of malignant cells to cytotoxic agents is often a limiting factor to successful chemotherapy. The classical multidrug resistance is characterised by overexpression of a membrane protein, P-glycoprotein, which acts like a drug extruding pump reducing accumulation of cytotoxic agents inside malignant cells, thereby preventing their function ...
M I, Tiirikainen, T, Krusius
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Multidrug-resistant tuberculosis [PDF]
The Lancet, 2019 The ideal number of drugs needed and treatment duration are crucial issues in the management of multidrug-resistant tuberculosis (MDR-TB). Thus, we read with interest the Article by the Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017,1 the results of which support our proposal,2 from 2015, to classify anti ...
Bern-Thomas, Nyang'wa +3 more
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Multidrug resistance associated proteins in multidrug resistance [PDF]
Chinese Journal of Cancer, 2012 Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins named ATP-binding cassette (ABC) transporters. These ABC transporters together form the largest branch of proteins within the human body. The MRP family comprises of 13 members, of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance
Sodani, Kamlesh +3 more
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Tropical Animal Science Journal, 2021 This study was aimed to find out that broiler chicken farms have problems with antibiotic resistance Citrobacter freundii and determined the prevalence and class 1 integron encoding gene.
A. M. Witaningrum +3 more
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Informatics in Medicine Unlocked, 2021 Development of multidrug resistance is the main obstacle for treating infections of Pseudomonas aeruginosa, an opportunistic pathogen responsible for a wide range of persistent infections throughout the body.
Nazanin Hosseinkhan +2 more
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Canadian Journal of Infectious Diseases and Medical Microbiology, 2020 Objective. This study aimed to detect 5 kinds of genes related to plasmid-mediated quinolone resistance in four species of nonfermenting bacteria with 2 drug resistance phenotypes (multidrug resistance and pandrug resistance), which were Acinetobacter ...
De-Song Ming +2 more
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Microbiology Spectrum, 2022 The spread of resistance genes via horizontal plasmid transfer plays a significant role in the formation of multidrug-resistant (MDR) Pseudomonas aeruginosa strains. Here, we identified a megaplasmid (ca.
Meng Li +6 more
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Multidrug Resistance in Fungi [PDF]
Eukaryotic Cell, 2007 One of the major advances serving to define the beginning of the era of modern medicine was the development of penicillin in the early 1940s as the first widely used antibiotic effective against microorganisms (reviewed in reference [111][1]). In what has become an all-too-common trend, antibiotic-
Kailash, Gulshan, W Scott, Moye-Rowley
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