Results 1 to 10 of about 1,577,899 (206)

Multidrug-resistant tuberculosis

Revista Ciencias Biomédicas, 2013
Introduction: tuberculosis is an increasing problem of global health and the microbialdrug resistance a generating element of worry.Clinical case: 19 year-old patient, who admitted to the emergency room for presentinghemoptysis and who had history of ...
Álvarez-Gaviria Manuel, De-la-Vega Fernando, Bello-Espinosa Ariel, Lora-Hurtado Merle, Navas-Torrejano Diana, Herazo-Bustos Cherina   +5 more
doaj  

Environmental fungi target thiol homeostasis to compete with Mycobacterium tuberculosis.

PLoS Biology
Mycobacterial species in nature are found in abundance in sphagnum peat bogs where they compete for nutrients with a variety of microorganisms including fungi. We screened a collection of fungi isolated from sphagnum bogs by co-culture with Mycobacterium
Neha Malhotra, Sangmi Oh, Peter Finin, Jessica Medrano, Jenna Andrews, Michael Goodwin, Tovah E Markowitz, Justin Lack, Helena I M Boshoff, Clifton Earl Barry   +9 more
doaj   +1 more source

Design and in silico screening of novel isoniazid-based Schiff base derivatives followed by synthesis and biological evaluation of the lead compound against Mycobacterium tuberculosis H37Rv

Discover Chemistry
The development of new antitubercular agents is critically needed due to the rising incidence of drug-resistant Mycobacterium tuberculosis. In the present study, a series of isoniazid-based Schiff base derivatives was designed and evaluated using an ...
Shivani L. Bhuse, Pallavi M. Patil, Rajat R. Durbule   +2 more
doaj   +1 more source

Pyrazinamide-derived hydrazone outperforms pyrazinamide activity in Mycobacterium tuberculosis DM97: an in vitro and in silico study

Eclética Química
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (MTB). Pyrazinamide (PZA) is a prodrug used in first-lines treatment. New drugs proposals are urgent, given the increased resistance to antimicrobials such as PZA.
Christian Aliaga Paucar, Jesús Antonio Alvarado-Huayhuaz, Henrry Rene Gutierrez Vega, Ramirez Panti Rocio, Mirko Zimic Peralta, Patricia Sheen Cortavarria, Ana Valderrama Negrón   +6 more
doaj   +1 more source

Exploration of 4-aminopyrrolo[2,3-d]pyrimidine as antitubercular agents. [PDF]

Mol Divers, 2023
Jesumoroti OJ, Beteck RM, Jordaan A, Warner DF, Legoabe LJ.   +4 more
europepmc   +1 more source

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome in Pulmonary Tuberculosis Patient with Type 2 Respiratory Failure and Sepsis

International Journal of Mycobacteriology
While anti-tuberculosis drugs (ATDs) are essential for tuberculosis (TB) treatment, they can induce severe hypersensitivity reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.
Brigita Sanina Manullang, Isnin Anang Marhana   +1 more
doaj   +1 more source

Investigating the Roles of Active Site Residues in Mycobacterium tuberculosis Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents. [PDF]

ACS Bio Med Chem Au, 2023
Konas DW, Cho S, Thomas OD, Bhatti MM, Leon Hernandez K, Moran C, Booter H, Candela T, Lacap J, McFadden P, van den Berg S, Welter AM, Peralta A, Janson CA, Catalano J, Goodey NM.   +15 more
europepmc   +1 more source

Intensive Management of a Patient with HIV, Active Tuberculosis, and COVID-19: A Multidisciplinary Approach in the Intensive Care Unit

Life
Coinfection with HIV, active tuberculosis, and COVID-19 is rare but markedly increases mortality risk and complicates treatment due to the interactions between these infections.
Brayan Ricardo Mosquera-Arias, Valeria Sanclemente-Cardoza, Jose Luis Estela-Zape   +2 more
doaj   +1 more source

Molecular insights into Mmpl3 leads to the development of novel indole-2-carboxamides as antitubercular agents. [PDF]

Mol Syst Des Eng, 2022
Ray R, Birangal SR, Fathima F, Boshoff HI, Forbes HE, Chandrashekhar RH, Shenoy GG.   +6 more
europepmc   +1 more source

Antitubercular Agent [PDF]

, 2020
openaire   +1 more source