Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents [PDF]
Pharmaceuticals, 2021 Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of Mycobacterium tuberculosis (Mtb) have developed resistance against most of the established ...
Matteo Mori +8 more
doaj +4 more sources
Novel Pyrimidines as Antitubercular Agents. [PDF]
Antimicrob Agents Chemother, 2018 ABSTRACT Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics. A triazine antitubercular hit led to the design of a related pyrimidine family.
Inoyama D +13 more
europepmc +5 more sources
Exploration of Piperidinols as Potential Antitubercular Agents [PDF]
Molecules, 2014 Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N ...
Areej Abuhammad +6 more
doaj +8 more sources
Development of 6-Methanesulfonyl-8-nitrobenzothiazinone Based Antitubercular Agents [PDF]
ACS Medicinal Chemistry Letters, 2022 The 6-trifluoro substituted 8-nitrobenzothiazinones (BTZs) represent a novel type of antitubercular agents, and their high antimycobacterial activity is related to the inhibition of decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), an enzyme essential ...
Giovanni Stelitano +2 more
exaly +5 more sources
Dataset of 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole derivatives for GQSAR of antitubercular agents [PDF]
Data in Brief, 2017 Fragment based Quantitative structure activity relationship (QSAR) analysis on reported 25 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole dataset as antitubercular agents were carried out.
Amit S. Tapkir +2 more
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Beni-Suef University Journal of Basic and Applied Sciences, 2015 Emergence of multi-drug resistant tuberculosis (MDR-TB) and HIV-TB co-infections potentiate the development of newer antitubercular agents to combat against tuberculosis, a dreadful disease.
Mohamed Jawed Ahsan, Veerendra Saini
doaj +4 more sources
Causality assessment, severity and preventability of adverse drug reactions due to first-line antitubercular agents [PDF]
Pharmaciana, 2022 TB (Tuberculosis) is a common infectious disease affecting humans since very long time. Multidrug therapy with its associated adverse drug reactions is one of the major concerns for the management of TB.
Gunjan Upadhyay +2 more
doaj +3 more sources
Phytogenic silver, gold, and bimetallic nanoparticles as novel antitubercular agents [PDF]
International Journal of Nanomedicine, 2016 Richa Singh,1 Laxman Nawale,2 Manisha Arkile,2 Sweety Wadhwani,1 Utkarsha Shedbalkar,1 Snehal Chopade,1 Dhiman Sarkar,2 Balu Ananda Chopade1,3 1Department of Microbiology, Savitribai Phule Pune University, 2Combichem-Bioresource Center, Organic ...
Singh R +7 more
doaj +2 more sources
Identification of Better Pharmacokinetic Benzothiazinone Derivatives as New Antitubercular Agents [PDF]
ACS Medicinal Chemistry Letters, 2017 Kai Lv, Xuefu You, Yun Chai
exaly +2 more sources
Journal of Nepal Medical Association, 2021 Introduction: Sputum non-conversion is smear positive tuberculosis despite anti-tubercular therapy. Various factors may lead to sputum non-conversion including resistance to anti-tubercular drugs, age, gender, disease severity, non-compliance, drugs ...
Naveen Prakash Shah +5 more
doaj +1 more source