Results 11 to 20 of about 17,370 (212)

The Value of Enzyme-linked Immunospot Assay in Identifying Causative Agents in Patients with Hypersensitivity Reactions to Antitubercular Agents [PDF]

Zhongguo quanke yixue
Background Hypersensitivity reactions of antitubercular agents are very common in clinical practice. Drug provocation test is the only effective method to find out the causative agents, but it may cause re-sensitization or even shock, which can be life ...
WU Yuqing, LIU Zhou, LIAO Yongmei
doaj   +2 more sources

Synthesis and Biological Evaluation of 2-(3-Fluoro-4-nitro phenoxy)-N-phenylacetamide Derivatives as Novel Potential Affordable Antitubercular Agents

Molecules, 2012
A novel series of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide compounds were designed, synthesized and in vitro assessed for their antitubercular activities by a microdilution method.
Yu-Quan Wei, Tao Yang, Jian-Zhong Yang, Wei-Yi Pi, Ying-Hong Yang, You-Fu Luo, Yong Deng, Yan-Ni Lin, Wei Ang   +8 more
doaj   +2 more sources

Screening of the antimycobacterial activity of novel lipophilic agents by the modified broth based method

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2016
Most of the introduced susceptibility methods of Mycobacterium tuberculosis have some disadvantages for screening. Therefore, the selection of susceptibility assay for evaluating candidate agents must be determined case by case.
Mehdi Zandhaghighi, Kiarash Ghazvini, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Saman Soleimanpour, Farzin Hadizadeh   +6 more
doaj   +1 more source

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

Pathogens, 2018
Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure
Davide M. Ferraris, Riccardo Miggiano, Franca Rossi, Menico Rizzi   +3 more
doaj   +1 more source

Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents

Pharmaceuticals, 2020
This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose de Leon   +3 more
doaj   +1 more source

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2014
The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB bacilli.
Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee   +12 more
doaj   +1 more source

A rare case of tuberculosis spine on antitubercular drug succumbing to pseudomembranous enterocolitis

Journal of Dr. NTR University of Health Sciences, 2021
Anti-tubercular therapy (ATT) drugs are the mainstay of management of tuberculosis worldwide. These medicines are used extensively across the globe in treating tubercular infections of any organ.
Simarjit S Rehsi, Nilanjan Roy, Vipin V Nair, Ajay K Baranwal, Prashant Sengupta, Pawan Sharma, Aman Kumar   +6 more
doaj   +1 more source

Studies on new substituted pyridazinones: synthesis and biological evaluation

Brazilian Journal of Pharmaceutical Sciences, 2018
We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents.
Mohammad Asif, Anita Singh, Shah Alam Khan, Asif Husain   +3 more
doaj   +1 more source

PYRAZOLINES AS POTENT ANTITUBERCULAR AND CYTOTOXIC AGENTS

, 2017
Objective: Pyrazolines are known to exhibit different biological and pharmacological properties such as anticancer, antibacterial, antifungal and antitubercular activities.
K, Ishwar Bhat, Kumar, Abhishek
core   +2 more sources

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

Journal of Taibah University for Science, 2019
We initiated a program to synthesize thiazolidinone derivatives as antitubercular agent by preparing hybrid molecules having the similar features of reported potent antitubercular agents.
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate   +6 more
doaj   +1 more source