Results 1 to 10 of about 23,044 (143)
Frontiers in Chemistry, 2020 The present work reports two novel pharmaceutical co-crystals; 2:1 isoniazid-glutaric acid (INHGA) and 2:1 pyrazinamide-glutaric acid (PGA). Isoniazid and pyrazinamide are key first-line drugs used for the treatment of tuberculosis.
Jean Baptiste Ngilirabanga +3 more
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Synergistic Lethality of a Binary Inhibitor of
mBio, 2018 We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target.
Pradeep Kumar +32 more
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Cutaneous drug reaction secondary to antitubercular regimen: A case report from Nepal
SAGE Open Medical Case Reports, 2023 Cutaneous adverse drug reactions are known side effects of first-line antitubercular therapy, which ranges from mild pruritus to life-threatening toxic epidermal necrolysis.
Himal Bikram Bhattarai +9 more
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Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones
Molecules, 2017 Cinnamaldehyde is a natural product with broad spectrum of antibacterial activity. In this work, it was used as a template for design and synthesis of a series of 17 cinnamylideneacetophenones. Phenolic compounds 3 and 4 exhibited MIC (minimum inhibitory
Carlos R. Polaquini +10 more
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Molecules, 2020 According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities with HIV and diabetes are present. Incomplete therapeutic regimen,
Saad Alghamdi +5 more
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Molecules, 2018 The Red Sea specimen of the marine sponge Hyrtios erectus (order Dictyoceratida) was found to contain scalarane-type sesterterpenes. 12-O-deacetyl-12,19-di-epi-scalarin (14), a new scalarane sesterterpenoid, along with fourteen previously-reported ...
Abdulrahman M. Alahdal +6 more
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Synthesis and Biological Significance of Some 2-Azetidinone Derivatives [PDF]
Journal of Sciences, Islamic Republic of Iran, 2012 A new series of N-[2-(1H-1,2,3-benzotriazol-1-yl)ethyl]-4-(substitutedphenyl)-3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-j) were synthesized. The structures of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR,
P. Samadhiya
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When you never thought it would be me
APIK Journal of Internal Medicine, 2020 Tuberculosis, both pulmonary and extrapulmonary, is a procoagulant state, which can lead to deep-vein thrombosis and thromboembolism. Rifampicin, the antitubercular drug by itself, can cause a procoagulant state.
K R Raveendra +2 more
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Pathogens, 2018 Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure
Davide M. Ferraris +3 more
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Synthetic Routes and Bioactivity Profiles of the Phenothiazine Privileged Scaffold
OrganicsThis review offers a focused overview of the strategies used to build and modify phenothiazine (PTZ) derivatives. It covers both classical synthetic approaches and advances reported since 2014, including transition metal-catalyzed transformations and ...
Aigul E. Malmakova, Alan M. Jones
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