Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity [PDF]
Journal of the Serbian Chemical Society, 2012 A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material.
Samadhiya Pushkal +3 more
doaj +3 more sources
Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]
, 2013 Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
A Hill +48 more
core +23 more sources
Pharmaceutics, 2022 The scarcity of age-appropriate pharmaceutical formulations is one of the major challenges impeding successful management of tuberculosis (TB) prevalence in minors.
Penelope N. Rampedi +3 more
doaj +1 more source
Identification of Antimycobacterial Natural Products from a Library of Marine Invertebrate Extracts
Medicines, 2022 Tuberculosis (TB) remains a public health crisis, requiring the urgent identification of new anti-mycobacterial drugs. We screened several organic and aqueous marine invertebrate extracts for their in vitro inhibitory activity against the causative ...
Kojo Sekyi Acquah +6 more
doaj +1 more source
Microbiology Spectrum, 2023 We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal peptidase LepB. The seed molecule had 2-fold higher activity against the LepB hypomorph. Through a
Shilah Bonnett +7 more
doaj +1 more source
Inhalable spray-dried chondroitin sulphate microparticles: effect of different solvents on particle properties and drug activity [PDF]
, 2020 Spray-drying stands as one of the most used techniques to produce inhalable microparticles, but several parameters from both the process and the used materials affect the properties of the resulting microparticles.
Buttini, Francesca +6 more
core +1 more source
Synthesis and biological activity of 4-thiazolidinone derivatives of phenothiazine [PDF]
Journal of the Serbian Chemical Society, 2012 A new series of N-[3-(10H-phenothiazinyl)-propyl]-2-(substituted phenyl)-4-oxo-5-( substituted benzylidene)-1,3-thiazolidine-carboxamide, 5(as) have been synthesized.
Sharma Ritu +3 more
doaj +1 more source
Intestinal Perforation as a Paradoxical Reaction to Antitubercular Therapy: A Case Report [PDF]
Annals of Coloproctology, 2021 Paradoxical reactions to tuberculosis (TB) treatment are characterized by an initial improvement of the clinical symptoms followed by clinical or radiological deterioration of existing tuberculous lesions, or by development of new lesions.
Sung Hoon Kang +10 more
doaj +1 more source
Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
Pharmaceuticals, 2020 This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina +3 more
doaj +1 more source
Multifunctional nanocarriers for lung drug delivery [PDF]
, 2020 Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical ...
Grenha, Ana, Pontes, Jorge Filipe
core +2 more sources