Results 41 to 50 of about 34,847 (196)
Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor [PDF]
, 2016 Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy.
Martínez-Hoyos, María +29 more
core +3 more sources
European Journal of Organic Chemistry, EarlyView.A microwave‐enhanced sustainable and versatile approach to substituted benzofurans from 2‐alkynylanisoles enabled by an active Brønsted acidic deep eutectic solvent. The research on alternative media for organic transformations remains a highly demanding topic.
Alessandra Gritti +9 more
wiley +1 more source
Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones
Molecules, 2017 Cinnamaldehyde is a natural product with broad spectrum of antibacterial activity. In this work, it was used as a template for design and synthesis of a series of 17 cinnamylideneacetophenones. Phenolic compounds 3 and 4 exhibited MIC (minimum inhibitory
Carlos R. Polaquini +10 more
doaj +1 more source
iMetaMed, EarlyView.This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian +13 more
wiley +1 more source
Molecules, 2018 The Red Sea specimen of the marine sponge Hyrtios erectus (order Dictyoceratida) was found to contain scalarane-type sesterterpenes. 12-O-deacetyl-12,19-di-epi-scalarin (14), a new scalarane sesterterpenoid, along with fourteen previously-reported ...
Abdulrahman M. Alahdal +6 more
doaj +1 more source
Inhalable antitubercular therapy mediated by locust bean gum microparticles [PDF]
, 2016 Tuberculosis remains a major global health problem and alternative therapeutic approaches are needed. Considering the high prevalence of lung tuberculosis (80% of cases), the pulmonary delivery of antitubercular drugs in a carrier system capable of ...
Alves, Ana +5 more
core +2 more sources
Interdisciplinary Medicine, EarlyView.This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling +13 more
wiley +1 more source
Synthesis and Biological Significance of Some 2-Azetidinone Derivatives [PDF]
Journal of Sciences, Islamic Republic of Iran, 2012 A new series of N-[2-(1H-1,2,3-benzotriazol-1-yl)ethyl]-4-(substitutedphenyl)-3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-j) were synthesized. The structures of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR,
P. Samadhiya
doaj
Antituberculosis Activity of Brotowali (Tinospora Crispa) Extract and Fractions Against Mycobacterium Tuberculosis Using Microplate Alamar Blue Assay Method [PDF]
, 2017 Tuberculosis (TB), in which caused by pathogenic bacteria, Mycobacterium tuberculosis, has become the major causes of death among all of infectious diseases.
Irianti, T. (Tatang) +5 more
core