Results 31 to 40 of about 26,304 (200)
PharmaceuticalsWe present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity.
Juan F. González +8 more
doaj +1 more source
Synergistic Lethality of a Binary Inhibitor of
mBio, 2018 We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target.
Pradeep Kumar +32 more
doaj +1 more source
Cutaneous drug reaction secondary to antitubercular regimen: A case report from Nepal
SAGE Open Medical Case Reports, 2023 Cutaneous adverse drug reactions are known side effects of first-line antitubercular therapy, which ranges from mild pruritus to life-threatening toxic epidermal necrolysis.
Himal Bikram Bhattarai +9 more
doaj +1 more source
Current Progress in Differentiating Crohn's Disease From Intestinal Tuberculosis
iLABMED, EarlyView.Currently, there are various methods from different fields used to differentiate Crohn's disease from intestinal tuberculosis (ITB). Endoscopic findings are an important cornerstone. They can be used individually or in combination (models) to demonstrate excellent discriminative ability.
Chuyao Zhang, Xiaoyin Zhang
wiley +1 more source
iMetaMed, EarlyView.This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian +13 more
wiley +1 more source
Molecules, 2020 According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities with HIV and diabetes are present. Incomplete therapeutic regimen,
Saad Alghamdi +5 more
doaj +1 more source
Novel Pyrimidines as Antitubercular Agents
, 2018 Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics.
Véronique Dartois +13 more
core +1 more source
Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones
Molecules, 2017 Cinnamaldehyde is a natural product with broad spectrum of antibacterial activity. In this work, it was used as a template for design and synthesis of a series of 17 cinnamylideneacetophenones. Phenolic compounds 3 and 4 exhibited MIC (minimum inhibitory
Carlos R. Polaquini +10 more
doaj +1 more source
Stable Tricyclic Antitubercular Ozonides Derived from Artemisinin
, 2015 New, highly stable tricyclic antitubercular ozonides 9 and 10 derived from artemisinin are reported in 39 and 9% yields, respectively. The ozonide groups of 9 and 10 were found to be stable under strong basic and acidic conditions.
Sudhir K. Sinha (1508245) +8 more
core +1 more source
Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales +12 more
wiley +1 more source