Results 11 to 20 of about 26,304 (200)
Antitubercular drug poisoning in a pregnant woman
Indian Journal of Anaesthesia, 2010 A 20-year-old female in her third month of pregnancy, presented with generalised tonic clonic seizures, metabolic acidosis and coma following suicidal ingestion of antitubercular medication.
Rahul Dutta +2 more
doaj +2 more sources
Türk Oftalmoloji Dergisi, 2016 In this study, a case with tubercular choroiditis showing severe macular edema and progression of choroidal lesions following initiation of antitubercular treatment is presented and the management of posterior uveitis associated with tuberculosis is ...
Ebru Esen +3 more
doaj +2 more sources
Randomized, Placebo-Controlled, First-in-Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Oral Doses of Novel Antitubercular Drug Candidate, GSK2556286, in Healthy Adults. [PDF]
J Clin PharmacolAbstract This first‐in‐human study (ClinicalTrials.gov identifier: NCT04472897) evaluated the safety, tolerability, pharmacokinetics, and food effect of single ascending and repeat oral doses of GSK2556286 (GSK286), a novel antitubercular drug candidate with efficacy in animal models of tuberculosis.
Ilsley E +9 more
europepmc +2 more sources
Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility. [PDF]
, 2020 Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases.
Sykes, Melissa L +16 more
core +1 more source
Development of 6Methanesulfonyl-8-nitrobenzothiazinone Based Antitubercular Agents
, 2022 The 6-trifluoro substituted 8-nitrobenzothiazinones (BTZs) represent a novel type of antitubercular agents, and their high antimycobacterial activity is related to the inhibition of decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), an enzyme essential ...
Bin Wang +19 more
core +3 more sources
Molecules, 2021 Antimicrobial resistance was one of the top priorities for global public health before the start of the 2019 coronavirus pandemic (COVID-19). Moreover, in this changing medical landscape due to COVID-19, finding new organic structures with antimicrobial ...
Maria Marinescu
doaj +1 more source
An Atypical Presentation of Tuberculous Ascites, Severe Hyponatremia, and Acute Kidney Injury in a Young Male. [PDF]
Clin Case RepABSTRACT A 25‐year‐old male who had been in good health before presenting with right lower lobe pneumonia, severe hyponatremia (Na 117 mEq/L), distension, and reduced urine output. AKI secondary to acute glomerulonephritis (GN) or interstitial nephritis was suggested by the initial workup. He was discharged for outpatient nephrology follow‐up following
Al Hariri B +5 more
europepmc +2 more sources
Pyrimidine derivatives with antitubercular activity [PDF]
, 2023 Small molecules with antitubercular activity containing the pyrimidine motif in their structure have gained more attention after three drugs, namely GSK 2556286 (GSK-286), TBA-7371 and SPR720, have entered clinical trials.
Roh, Jaroslav +5 more
core
Molecules, 2023 Novel antitubercular compounds are urgently needed to combat drug-resistant Mycobacterium tuberculosis (Mtb). Filamentous actinobacteria have historically been an excellent source of antitubercular drugs.
Daniel J. Watson +4 more
doaj +1 more source
Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives
, 2021 1 2 4-Triazole; Antitubercular activities ...
신윤용, 김대기, 박혜영
core +1 more source