Results 11 to 20 of about 27,938 (191)

Antitubercular drug poisoning in a pregnant woman

Indian Journal of Anaesthesia, 2010
A 20-year-old female in her third month of pregnancy, presented with generalised tonic clonic seizures, metabolic acidosis and coma following suicidal ingestion of antitubercular medication.
Rahul Dutta, Surya Kumar Dube, Dinesh Kumar Singh   +2 more
doaj   +2 more sources

Paradoxical Worsening of Tubercular Serpiginous-Like Choroiditis after Initiation of Antitubercular Therapy

Türk Oftalmoloji Dergisi, 2016
In this study, a case with tubercular choroiditis showing severe macular edema and progression of choroidal lesions following initiation of antitubercular treatment is presented and the management of posterior uveitis associated with tuberculosis is ...
Ebru Esen, Selçuk Sızmaz, Zeynep Kunt, Nihal Demircan   +3 more
doaj   +2 more sources

Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones

Molecules, 2017
Cinnamaldehyde is a natural product with broad spectrum of antibacterial activity. In this work, it was used as a template for design and synthesis of a series of 17 cinnamylideneacetophenones. Phenolic compounds 3 and 4 exhibited MIC (minimum inhibitory
Carlos Roberto Polaquini, Luis Regasini, Isabel Silva   +2 more
exaly   +3 more sources

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues [PDF]

, 2013
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis ...
Vialla, Emilie, Gannoun-Zaki, Laila, Kremer, Laurent, Craig, Derek, Coxon, Geoffrey, Corrales, Rosa Milagros   +5 more
core   +5 more sources

A Micro-Configured Multiparticulate Reconstitutable Suspension Powder of Fixed Dose Rifampicin and Pyrazinamide: Optimal Fabrication and In Vitro Quality Evaluation

Pharmaceutics, 2022
The scarcity of age-appropriate pharmaceutical formulations is one of the major challenges impeding successful management of tuberculosis (TB) prevalence in minors.
Penelope N. Rampedi, Modupe O. Ogunrombi, James Wesley-Smith, Oluwatoyin A. Adeleke   +3 more
doaj   +1 more source

Identification of Antimycobacterial Natural Products from a Library of Marine Invertebrate Extracts

Medicines, 2022
Tuberculosis (TB) remains a public health crisis, requiring the urgent identification of new anti-mycobacterial drugs. We screened several organic and aqueous marine invertebrate extracts for their in vitro inhibitory activity against the causative ...
Kojo Sekyi Acquah, Denzil R. Beukes, Ronnett Seldon, Audrey Jordaan, Suthananda N. Sunassee, Digby F. Warner, David W. Gammon   +6 more
doaj   +1 more source

Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis

Microbiology Spectrum, 2023
We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal peptidase LepB. The seed molecule had 2-fold higher activity against the LepB hypomorph. Through a
Shilah Bonnett, Jo-Ann Jee, Somsundaram Chettiar, Yulia Ovechkina, Aaron Korkegian, Eric Greve, Joshua Odingo, Tanya Parish   +7 more
doaj   +1 more source

Synthesis and biological activity of 4-thiazolidinone derivatives of phenothiazine [PDF]

Journal of the Serbian Chemical Society, 2012
A new series of N-[3-(10H-phenothiazinyl)-propyl]-2-(substituted phenyl)-4-oxo-5-( substituted benzylidene)-1,3-thiazolidine-carboxamide, 5(as) have been synthesized.
Sharma Ritu, Samadhiya Pushkal, Srivastava Savitri D., Srivastava Santosh K.   +3 more
doaj   +1 more source

Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity [PDF]

Journal of the Serbian Chemical Society, 2012
A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material.
Samadhiya Pushkal, Sharma Ritu, Srivastava Santosh K., Srivastava Savitri D.   +3 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source