Results 21 to 30 of about 26,304 (200)

Fluorinated chalcones, pyridine and pyran derivatives with significant antitubercular activity.

, 2022
Fluorinated chalcones, pyridine and pyran derivatives with significant antitubercular activity.
M. Mukhlesur Rahman (2100193), Venu Sampath Golla (12884210), Bontha Venkata Subrahmanya Lokesh (12884213), Afzal Basha Shaik (12884216), Srinath Nissankararao (12884204), Rajendra Prasad Yejella (8937146), Surendra Babu Lagu (12884201), Richie R. Bhandare (12884207)   +7 more
core   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

PYRAZOLINES AS POTENT ANTITUBERCULAR AND CYTOTOXIC AGENTS

, 2017
Objective: Pyrazolines are known to exhibit different biological and pharmacological properties such as anticancer, antibacterial, antifungal and antitubercular activities.
K, Ishwar Bhat, Kumar, Abhishek
core   +2 more sources

Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities

Molecules, 2020
Infectious diseases caused by fungi and mycobacteria pose an important problem for humankind. Similarly, cancer is one of the leading causes of death globally.
Afzal B. Shaik, Richie R. Bhandare, Srinath Nissankararao, Zehra Edis, N. Ravikiran Tangirala, Shaik Shahanaaz, M. Mukhlesur Rahman   +6 more
doaj   +1 more source

Antioxidant, Antitubercular and Cytotoxic Activities of Piper imperiale

Molecules, 2012
Phenolic compounds are widely distributed in Nature and act as pharmacologically active constituents in many herbal medicines. They have multiple biological properties, most notably antioxidant, antibacterial and cytotoxic activities.
Sanjib Bhakta, Juan D. Guzman, Diego L. Gonzalez, Rosa E. Prieto, Sergio A. Cuervo, Luis E. Diaz, Diego R. Munoz   +6 more
doaj   +1 more source

Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives

Molecules, 2015
A series of 5H-thiazolo[3,2-a]pyrimidin-5-ones were synthesized by the cyclization reactions of S-alkylated derivatives in concentrated H2SO4. Upon treatment of S-alkylated derivatives at different temperatures, intramolecular cyclization to 7 ...
Dong Cai, Zhi-Hua Zhang, Yu Chen, Xin-Jia Yan, Liang-Jing Zou, Ya-Xin Wang, Xue-Qi Liu   +6 more
doaj   +1 more source

Synthesis and Biological Evaluation of 2-(3-Fluoro-4-nitro phenoxy)-N-phenylacetamide Derivatives as Novel Potential Affordable Antitubercular Agents

Molecules, 2012
A novel series of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide compounds were designed, synthesized and in vitro assessed for their antitubercular activities by a microdilution method.
Yu-Quan Wei, Tao Yang, Jian-Zhong Yang, Wei-Yi Pi, Ying-Hong Yang, You-Fu Luo, Yong Deng, Yan-Ni Lin, Wei Ang   +8 more
doaj   +1 more source

The Synergistic Effects of the Glutathione Precursor, NAC and First-Line Antibiotics in the Granulomatous Response Against Mycobacterium tuberculosis

Frontiers in Immunology, 2018
Mycobacterium tuberculosis (M. tb), the causative bacterial agent responsible for tuberculosis (TB) continues to afflict millions of people worldwide. Although the human immune system plays a critical role in containing M.
Garrett Teskey, Ruoqiong Cao, Ruoqiong Cao, Hicret Islamoglu, Albert Medina, Chaya Prasad, Ramaa Prasad, Airani Sathananthan, Marcel Fraix, Selvakumar Subbian, Li Zhong, Li Zhong, Li Zhong, Vishwanath Venketaraman, Vishwanath Venketaraman   +14 more
doaj   +1 more source

Mechanochemical Synthesis and Physicochemical Characterization of Isoniazid and Pyrazinamide Co-crystals With Glutaric Acid

Frontiers in Chemistry, 2020
The present work reports two novel pharmaceutical co-crystals; 2:1 isoniazid-glutaric acid (INHGA) and 2:1 pyrazinamide-glutaric acid (PGA). Isoniazid and pyrazinamide are key first-line drugs used for the treatment of tuberculosis.
Jean Baptiste Ngilirabanga, Marique Aucamp, Paulo Pires Rosa, Halima Samsodien   +3 more
doaj   +1 more source

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues

, 2013
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis ...
Derek Craig, Rosa Milagros Corrales, Craig Derek, Gannoun-Zaki, Laila, Geoffrey D Coxon, Laila Gannoun-Zaki, Laurent Kremer, Gannoun-Zaki Laila, Emilie Vialla, Herrmann, Jean Louis, Coxon, Geoffrey, Corrales, Rosa Milagros, Coxon Geoffrey D., Vialla, Emilie, Kremer Laurent, Kremer, Laurent, Corrales Rosa Milagros, Vialla Emilie, Craig, Derek   +18 more
core   +1 more source