Results 51 to 60 of about 26,304 (200)

Skin Hyperpigmentation: An Under‐Recognized Dermatological Clue to Vitamin B12 Deficiency

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Hyperpigmentation over the dorsal aspect of both hands, prominently involving the knuckles. ABSTRACT Cutaneous hyperpigmentation, an overlooked manifestation, can be an early sign of vitamin B12 deficiency. This case highlights symmetric pigmentation on the dorsum of hands and palms in a long‐term vegetarian.
Mahesh Mathur, Sumit Paudel, Sambidha Karki, Sandhya Regmi, Shilpa Maharjan, Nabita Bhattarai   +5 more
wiley   +1 more source

Clinical Pharmacology Quality Assurance Program for Global HIV and Co‐Infection Drug Development

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1205-1215, May 2026.
When the acquired immunodeficiency syndrome emerged in the 1980s, the United States National Institutes of Health established research networks to conduct clinical trials with the pharmaceutical industry to identify effective antiretroviral therapeutics.
Robin DiFrancesco, Troy D. Wood, Raymond Cha, Jill S. Hochreiter, Susan L. Rosenkranz, Mona Farhad, Kyle R. Whitson, Connor E. Gould, Lauren E. Hill, Linda L. Hale, Philip H. Lindhorst, Diala Ghazal, Charlene R. Taylor, Madiha Quraishi, Suzanne M. Siminski, Yoninah Cramer, Heather L. Sprenger, Gene D. Morse   +17 more
wiley   +1 more source

Structures of CpIMPDH inhibitors with antitubercular activity.

, 2015
Structures of CpIMPDH inhibitors with antitubercular activity.
Andrzej Joachimiak (143860), Suresh Kumar Gorla (803689), Minjia Zhang (803691), Youngchang Kim (206917), Gyan Modi (803693), Courtney Aldrich (803695), Yang Wei (452371), Kavitha Mandapati (803690), Magdalena Makowska-Grzyska (560874), Natalia Maltseva (803692), Lizbeth Hedstrom (240663), Helena I. Boshoff (198809), Minyi Gu (803694), Gregory D. Cuny (249276)   +13 more
core   +1 more source

Synthetic Routes and Bioactivity Profiles of the Phenothiazine Privileged Scaffold

Organics
This review offers a focused overview of the strategies used to build and modify phenothiazine (PTZ) derivatives. It covers both classical synthetic approaches and advances reported since 2014, including transition metal-catalyzed transformations and ...
Aigul E. Malmakova, Alan M. Jones
doaj   +1 more source

Cinnamic Derivatives as Antitubercular Agents: Characterization by Quantitative Structure–Activity Relationship Studies

Molecules, 2020
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains one of the top ten causes of death worldwide and the main cause of mortality from a single infectious agent.
Cátia Teixeira, Cristina Ventura, José R. B. Gomes, Paula Gomes, Filomena Martins   +4 more
doaj   +1 more source

Interpretable machine learning enables early and accurate detection of drug‐induced liver injury: A multicenter study with real‐world clinical translation

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling, Shian Zhang, Jun Lin, Zhengju Xu, Runcheng Xu, Qian Lv, Kaixiang Zhang, Sheng Liu, Jie Guo, Cheng Hua, Yin Jia, Xiaoyu Xu, Kun Qian, Shanrong Liu   +13 more
wiley   +1 more source

Spray-dried fucoidan microparticles for pulmonary delivery of antitubercular drugs

, 2018
Pulmonary tuberculosis accounts for 80% of cases and the delivery of antitubercular drugs into the lungs allows targeting the infected organ and, possibly, reducing systemic drug toxicity.
Grenha A., Rosa Da Costa, Ana, Buttini, Francesca, Lourenco J. P., Cunha, Ludmylla, Rosa da Costa, Ana M., Rosa da Costa A. M., Buttini F., Lourenço, João P., Cunha L., Grenha, Ana   +10 more
core   +1 more source

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

Journal of Taibah University for Science, 2019
We initiated a program to synthesize thiazolidinone derivatives as antitubercular agent by preparing hybrid molecules having the similar features of reported potent antitubercular agents.
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate   +6 more
doaj   +1 more source

Gaining insights into MmpL3: combining structural and computational approaches to unlock transport and inhibitor‐binding mechanisms

Acta Crystallographica Section D, Volume 82, Issue 5, Page 550-570, May 2026.
This study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Satoshi Murakami, Domenico Marson, Eiki Yamashita, Bruno Broshka, Ui Okada, Maho Aoki, Giannamaria Annunziato, Erik Laurini, Emanuele Carosati, Marco Pieroni   +9 more
wiley   +1 more source

Synthesis and Antitubercular Activity of Some Novel Thiazolidinone Derivatives

, 2012
Purpose: To synthesize and characterize novel thiazolidinone derivatives and screen them for antitubercular activity. Methods: A series of twelve novel thiazolidinones 4a-l have been synthesized by cyclocondensation of various Schiff bases of amino ...
Sikarwar, Mukesh S, Malipeddi, H, Karigar, AA, Malipeddi, VR, Malipeddi, Himaja, Karigar, Asif A, Malipeddi, Venkata Ramana, Sikarwar, MS   +7 more
core   +3 more sources