Results 51 to 60 of about 27,938 (191)
Synthesis and Antitubercular Activity of Some Novel Thiazolidinone Derivatives [PDF]
, 2012 Purpose: To synthesize and characterize novel thiazolidinone derivatives and screen them for antitubercular activity. Methods: A series of twelve novel thiazolidinones 4a-l have been synthesized by cyclocondensation of various Schiff bases of amino ...
Sikarwar, Mukesh S +7 more
core +4 more sources
Synthesis and Biological Significance of Some 2-Azetidinone Derivatives [PDF]
Journal of Sciences, Islamic Republic of Iran, 2012 A new series of N-[2-(1H-1,2,3-benzotriazol-1-yl)ethyl]-4-(substitutedphenyl)-3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-j) were synthesized. The structures of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR,
P. Samadhiya
doaj
Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.Design and synthesis of novel 1,2,3‐triazole conjugates featuring hydroxamic acid and sulfonamide moieties: exploring dual pharmacophores for enhanced biological activity. ABSTRACT A new series of N‐hydroxy‐1‐(4‐(aryl sulfonamido)phenyl)‐1H‐1,2,3‐triazole‐4‐carboxamide derivatives (8a‐j) were synthesized through a concise multistep route integrating ...
Dineshkumar Pagar +4 more
wiley +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
When you never thought it would be me
APIK Journal of Internal Medicine, 2020 Tuberculosis, both pulmonary and extrapulmonary, is a procoagulant state, which can lead to deep-vein thrombosis and thromboembolism. Rifampicin, the antitubercular drug by itself, can cause a procoagulant state.
K R Raveendra +2 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Five novel series of isatin–Schiff base derivatives are synthesized and evaluated for neuroprotective and anti‐infective potential. The compounds demonstrate exceptional, reversible, and competitive monoamine oxidase inhibition, with chloro‐substitutions dictating isoform selectivity.
Marthinus J. Jooste +4 more
wiley +1 more source
Archiv der Pharmazie, Volume 359, Issue 8, August 2026.This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan +2 more
wiley +1 more source
Novel Pyrimidines as Antitubercular Agents
, 2018 Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics.
Véronique Dartois +13 more
core +1 more source
Brain and Behavior, Volume 16, Issue 8, August 2026.ABSTRACT Background Tuberculous meningitis (TBM) carries a case fatality rate of up to 50% in resource‐limited settings despite standard anti‐tuberculosis therapy. Adjunctive corticosteroids are widely recommended, yet their effect on mortality and safety across diverse populations remains imprecisely defined.
Ayesha Younas +14 more
wiley +1 more source
Stable Tricyclic Antitubercular Ozonides Derived from Artemisinin
, 2015 New, highly stable tricyclic antitubercular ozonides 9 and 10 derived from artemisinin are reported in 39 and 9% yields, respectively. The ozonide groups of 9 and 10 were found to be stable under strong basic and acidic conditions.
Sudhir K. Sinha (1508245) +8 more
core +1 more source