Results 51 to 60 of about 34,847 (196)

Asymmetric Transformations of α,β‐Unsaturated Oxazolidinones Catalyzed by C2‐Symmetric Chiral Iron Triad Complexes

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
This review highlights the evolution of highly enantioselective oxazolidinone transformations enabled by C2‐symmetric ligands, with emphasis on chiral iron triad complexes as cost‐effective, environmentally benign alternatives to late‐transition‐metal catalysts.
Arthur David, Thierry Ollevier
wiley   +1 more source

When you never thought it would be me

APIK Journal of Internal Medicine, 2020
Tuberculosis, both pulmonary and extrapulmonary, is a procoagulant state, which can lead to deep-vein thrombosis and thromboembolism. Rifampicin, the antitubercular drug by itself, can cause a procoagulant state.
K R Raveendra, H Sivaranjani, Shivakumar Hrishikesh   +2 more
doaj   +1 more source

An Atypical Presentation of Tuberculous Ascites, Severe Hyponatremia, and Acute Kidney Injury in a Young Male

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT A 25‐year‐old male who had been in good health before presenting with right lower lobe pneumonia, severe hyponatremia (Na 117 mEq/L), distension, and reduced urine output. AKI secondary to acute glomerulonephritis (GN) or interstitial nephritis was suggested by the initial workup. He was discharged for outpatient nephrology follow‐up following
Bassem Al Hariri, Muhammad Sharif, Memon Noor Illahi, Asgad Mohamed Ahmed Eltigani, Usamah Saad Mohammad Al Anbagi, Muayad Ahmad   +5 more
wiley   +1 more source

Antitubercular therapy decreases nitric oxide production in HIV/TB coinfected patients [PDF]

, 2002
Background: Nitric oxide (N) production is increased among patients with human immunodeficiency virus (HIV) infection and also those with tuberculosis ( B).
A Wanchu, A Bhatnagar, M Khullar, A Sud, P Bambery, S Singh, JL Jimenez, KD Kroncke, S Moncarda, A Wanchu, A Wanchu, A Wanchu, A Wanchu, HHW Schmidt, R Zangerle, E Hermann, A Wanchu, TG Evans, CH Wang, CH Wang, M Garcia, JB Mannick, J Gonzalez-Nicolas, R Zangerle, PA Selwyn, A Wanchu, T Schon, LC Green, TR Boyde, FP Huang, E Moilanen, HM Lander, SM Williams, AS Fauci, G Giovannoni, D Torre, D Torre, R Long, K Yu, JD MacMiking, A Bergamini, VP Mohan, C Immanuel, C Nathan, C Calleja   +44 more
core   +1 more source

Skin Hyperpigmentation: An Under‐Recognized Dermatological Clue to Vitamin B12 Deficiency

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Hyperpigmentation over the dorsal aspect of both hands, prominently involving the knuckles. ABSTRACT Cutaneous hyperpigmentation, an overlooked manifestation, can be an early sign of vitamin B12 deficiency. This case highlights symmetric pigmentation on the dorsum of hands and palms in a long‐term vegetarian.
Mahesh Mathur, Sumit Paudel, Sambidha Karki, Sandhya Regmi, Shilpa Maharjan, Nabita Bhattarai   +5 more
wiley   +1 more source

Phenothiazines as a solution for multidrug resistant tuberculosis:From the origin to present [PDF]

, 2015
Historically, multiplicity of actions in synthetic compounds is a rule rather than exception. The science of non-antibiotics evolved in this background.
Christensen, Jørn B, Das, Sukhen, Dastidar, Sujata G, Hendricks, Oliver, Kristiansen, Jette E, Palchoudhuri, Shauroseni, Roy, Debalina Sinha   +6 more
core   +4 more sources

Clinical Pharmacology Quality Assurance Program for Global HIV and Co‐Infection Drug Development

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1205-1215, May 2026.
When the acquired immunodeficiency syndrome emerged in the 1980s, the United States National Institutes of Health established research networks to conduct clinical trials with the pharmaceutical industry to identify effective antiretroviral therapeutics.
Robin DiFrancesco, Troy D. Wood, Raymond Cha, Jill S. Hochreiter, Susan L. Rosenkranz, Mona Farhad, Kyle R. Whitson, Connor E. Gould, Lauren E. Hill, Linda L. Hale, Philip H. Lindhorst, Diala Ghazal, Charlene R. Taylor, Madiha Quraishi, Suzanne M. Siminski, Yoninah Cramer, Heather L. Sprenger, Gene D. Morse   +17 more
wiley   +1 more source

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

Pathogens, 2018
Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure
Davide M. Ferraris, Riccardo Miggiano, Franca Rossi, Menico Rizzi   +3 more
doaj   +1 more source

Design, synthesis and biologival evaluation of novel isoniazid derivatives with potente antitubercular activity [PDF]

, 2014
The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has been driving the scientific community to urgently search for new and efficient antitubercular drugs.
Aires-de-Sousa, João, Correia, Henrique E., Elvas Leitao, Ruben, Kovalishyn, Vasyl, Latino, Diogo A. R. S., Martins, Filomena, Miranda, Vanessa, Ramos, Jorge, Reis, Marina, Santos, Lídia, Santos, Susana, Ventura, Cristina, Vitorino, Susana, Viveiros, Miguel   +13 more
core   +1 more source

Gaining insights into MmpL3: combining structural and computational approaches to unlock transport and inhibitor‐binding mechanisms

Acta Crystallographica Section D, Volume 82, Issue 5, Page 550-570, May 2026.
This study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Satoshi Murakami, Domenico Marson, Eiki Yamashita, Bruno Broshka, Ui Okada, Maho Aoki, Giannamaria Annunziato, Erik Laurini, Emanuele Carosati, Marco Pieroni   +9 more
wiley   +1 more source