Results 61 to 70 of about 27,938 (191)

Synthesis, antimicrobial and antitubercular activities of some novel pyrazoline derivatives [PDF]

, 2016
In the present study, two new series of pyrazolines (3a–h & 4a–h) were synthesized starting from p-acetamidophenol (paracetamol) and evaluated for their antibacterial, antifungal and antitubercular activities.
Aftab Ahmad, Asif Husain, Shah Alam Khan, Khan, Shah Alam, Mujeeb, Mohd., Husain, Asif, Bhandari, Anil, Ahmad, Aftab, Mohd. Mujeeb, Anil Bhandari   +9 more
core   +1 more source

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

Pathogens, 2018
Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure
Davide M. Ferraris, Riccardo Miggiano, Franca Rossi, Menico Rizzi   +3 more
doaj   +1 more source

Rare Pediatric Male Presentation of Systemic Lupus Erythematosus With Catastrophic Antiphospholipid Syndrome Following Pulmonary Tuberculosis: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT We report a 15‐year‐old with a 3‐year history of polyarthritis, unexplained seizures, and pulmonary tuberculosis who presented with acute neuropsychiatric decline, fever, and thrombocytopenia. Diagnostic workup confirmed systemic lupus erythematosus with triple‐positive antiphospholipid antibodies.
Asma Qureshi, Mahaveer Maheshwari, Aasiya Shahbaz Sakarwala, Umaya Memon, Vishan Das, Mumtaz Ali Lakho, Sandesh Kumar, Abdul Ghafoor, Siddhant Kumar Yadav   +8 more
wiley   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Synthetic Routes and Bioactivity Profiles of the Phenothiazine Privileged Scaffold

Organics
This review offers a focused overview of the strategies used to build and modify phenothiazine (PTZ) derivatives. It covers both classical synthetic approaches and advances reported since 2014, including transition metal-catalyzed transformations and ...
Aigul E. Malmakova, Alan M. Jones
doaj   +1 more source

Cinnamic Derivatives as Antitubercular Agents: Characterization by Quantitative Structure–Activity Relationship Studies

Molecules, 2020
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains one of the top ten causes of death worldwide and the main cause of mortality from a single infectious agent.
Cátia Teixeira, Cristina Ventura, José R. B. Gomes, Paula Gomes, Filomena Martins   +4 more
doaj   +1 more source

Endobronchial Hamartoma Masquerading as Endobronchial Tuberculosis—A Case Report

Respirology Case Reports, Volume 14, Issue 8, August 2026.
A 60‐year‐old man presented with persistent respiratory symptoms and an endobronchial mass in left lower lobe. Two successive forceps biopsies of the mass were non‐diagnostic. We used rigid bronchoscope as a conduit and performed bronchoscopic removal of the tumour using electrocautery snare and argon plasma coagulation. Excisional biopsy confirmed the
Manoj Kumar Panigrahi, Aneri Parekh, Shameema Farween, Siddarth Singh, Supantha De, Mukund Sable   +5 more
wiley   +1 more source

Genetic Landscape of NAT2 in the Moroccan Population: Implications for Isoniazid Pharmacogenetics in Tuberculosis

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The NAT2 gene encodes N‐acetyltransferase 2, an enzyme critically involved in the biotransformation of numerous xenobiotics and aromatic amines, including isoniazid, a cornerstone drug in tuberculosis therapy. Genetic polymorphisms in NAT2 lead to variable acetylation rates, clinically categorized as poor, intermediate, or rapid metabolizer ...
Nada Benyahya, Mohsine‐Ali El‐Hamri, Jaber Lyahyai, Ilham Ratbi, Imane Cherkaoui, Zineb Rchiad, Abdelaziz Sefiani   +6 more
wiley   +1 more source

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

Journal of Taibah University for Science, 2019
We initiated a program to synthesize thiazolidinone derivatives as antitubercular agent by preparing hybrid molecules having the similar features of reported potent antitubercular agents.
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate   +6 more
doaj   +1 more source

Pellagra in Contemporary Clinical Practice (2000–2023): A Systematic Review

International Journal of Dermatology, Volume 65, Issue 8, Page 1590-1599, August 2026.
This systematic review (2000–2023) of 1212 cases highlights pellagra's evolving etiology. While primary dietary deficiency (85%) persists in humanitarian crises, secondary forms from alcohol misuse (9.6%), isoniazid (14.3% of drug‐related cases), and malabsorption are rising.
Noureddine Litaiem, Karama Sboui, Faten Zeglaoui   +2 more
wiley   +1 more source