Results 81 to 90 of about 34,847 (196)

Analgesic Activity of Some 1,2,4-Triazole Heterocycles Clubbed with Pyrazole, Tetrazole, Isoxazole and Pyrimidine [PDF]

, 2013
Purpose: In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated.
Appala Raju, Popat Baban Mohite, Ramdas Bhanudas Pandhare, Shantaram Gajanan Khanage   +3 more
core   +1 more source

Atypical clinical and imaging manifestation in neurocysticercosis

Annals of Indian Academy of Neurology, 2011
A 20-year-old man presented with left-sided headache and seizures of three years duration. Conglomerate ring-enhancing lesions were seen in the first magnetic resonance imaging study. He was initially treated with anticonvulsants for two years.
L Dayananda, C Kesavadas, Bejoy Thomas, R Neelima, V V Radhakrishnan   +4 more
doaj   +1 more source

Defining the optimal dose of rifapentine for pulmonary tuberculosis: Exposure-response relations from two phase II clinical trials. [PDF]

, 2017
Rifapentine is a highly active antituberculosis antibiotic with treatment-shortening potential; however, exposure-response relations and the dose needed for maximal bactericidal activity have not been established.
Dooley, KE, Dorman, SE, Engle, M, Johnson, JL, MacKenzie, WR, Nahid, P, Nguyen, NV, Nsubuga, P, Peloquin, CA, Savic, RM, Tuberculosis Trials Consortium of the Centers for Disease Control and Prevention, Weiner, M, Whitworth, WC   +12 more
core   +1 more source

Drug metabolism by flavin-containing monooxygenases of human and mouse [PDF]

, 2016
Introduction: Flavin-containing monooxygenases (FMOs) play an important role in drug metabolism. / Areas covered: We focus on the role of FMOs in the metabolism of drugs in human and mouse.
Phillips, IR, Shephard, EA
core   +1 more source

PYRAZINAMIDE INDUCED ACUTE GOUTY ARTHRITIS

Journal of Nepal Medical Association, 2003
A typical case of pyrazinamide induced acute gouty arthritis in a tuberculous patient with antitubercular therapy including pyrazinamide was reported.
U N Pathak, B O Shrestha, R R Shrestha
doaj   +1 more source

Ligand-based discovery of novel N-arylpyrrole derivatives as broad-spectrum antimicrobial agents with antibiofilm and anti-virulence activity

Journal of Enzyme Inhibition and Medicinal Chemistry
The escalating threat of antimicrobial resistance calls for novel therapeutic agents. This study employed a ligand-based design approach to develop three series of N-arylpyrrole derivatives (Va–e, VIa–e, and VIIa–e), refined through molecular modeling ...
Basma M. Qandeel, Samar Mowafy, Mohamed F. El-Badawy, Nahla A. Farag, Galal Yahya, Khaled Abouzid   +5 more
doaj   +1 more source

Investigation of Antitubercular and Cytotoxic Activities of Fruit Extract and Isolated Compounds from Piper retrofractum Vahl

Walailak Journal of Science and Technology, 2016
A bioassay guided fractionation procedure used on the crude methanol extract of Piper retrofractum fruit identified 4 compounds: piperine, methyl piperate, sylvatine, and piperlonguminine.
Saranya AMAD, Supreeya YUENYONGSAWAD, Chatchai WATTANAPIROMSAKUL   +2 more
doaj  

Structural isomerisation affects the antitubercular activity of adamantyl-isoxyl adducts

Journal of Enzyme Inhibition and Medicinal Chemistry
Despite efforts to discover effective treatments to eradicate tuberculosis (TB), it remains a global threat. The increase in drug-resistant bacterial species has made the discovery of new drugs highly coveted.
Yucheng Lu, Daniel Partleton, Filibus M. Gugu, Ahmed Y. G. Alhejaili, Samuel Norris, J. Jonathan Harburn, Jason H. Gill, Jonathan D. Sellars, Alistair K. Brown   +8 more
doaj   +1 more source

Histomorphological features of combined forms of tuberculosis and lung cancer [PDF]

Medičnì Perspektivi, 2017
The were studied pathological features of combined forms of tuberculosis and non-small cell lung cancer in 72 patients who underwent radical surgical resection interventions from transsternal access with mediastinal lymph node dissection, with ...
Savenkov Y.F., Koshak Y.F., Malcev I.A., Korpusenko I.V., Bakulin P.E.   +4 more
doaj  

Screening of the antimycobacterial activity of novel lipophilic agents by the modified broth based method

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2016
Most of the introduced susceptibility methods of Mycobacterium tuberculosis have some disadvantages for screening. Therefore, the selection of susceptibility assay for evaluating candidate agents must be determined case by case.
Mehdi Zandhaghighi, Kiarash Ghazvini, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Saman Soleimanpour, Farzin Hadizadeh   +6 more
doaj   +1 more source