Results 81 to 90 of about 27,938 (191)

Structural isomerisation affects the antitubercular activity of adamantyl-isoxyl adducts

Journal of Enzyme Inhibition and Medicinal Chemistry
Despite efforts to discover effective treatments to eradicate tuberculosis (TB), it remains a global threat. The increase in drug-resistant bacterial species has made the discovery of new drugs highly coveted.
Yucheng Lu, Daniel Partleton, Filibus M. Gugu, Ahmed Y. G. Alhejaili, Samuel Norris, J. Jonathan Harburn, Jason H. Gill, Jonathan D. Sellars, Alistair K. Brown   +8 more
doaj   +1 more source

Spray-dried fucoidan microparticles for pulmonary delivery of antitubercular drugs

, 2018
Pulmonary tuberculosis accounts for 80% of cases and the delivery of antitubercular drugs into the lungs allows targeting the infected organ and, possibly, reducing systemic drug toxicity.
Grenha A., Rosa Da Costa, Ana, Buttini, Francesca, Lourenco J. P., Cunha, Ludmylla, Rosa da Costa, Ana M., Rosa da Costa A. M., Buttini F., Lourenço, João P., Cunha L., Grenha, Ana   +10 more
core   +1 more source

The Synthesis and Evaluation of N-Heterocycles as Antitubercular Agents

, 2021
Tuberculosis, the disease caused by the microbial pathogen Mycobacterium tuberculosis, is one of the world’s leading infectious causes of death. In 2019, the World Health Organisation estimated that 10 million new cases of tuberculosis were contracted ...
Martin, Liam Thomas
core   +1 more source

Investigation of Antitubercular and Cytotoxic Activities of Fruit Extract and Isolated Compounds from Piper retrofractum Vahl

Walailak Journal of Science and Technology, 2016
A bioassay guided fractionation procedure used on the crude methanol extract of Piper retrofractum fruit identified 4 compounds: piperine, methyl piperate, sylvatine, and piperlonguminine.
Saranya AMAD, Supreeya YUENYONGSAWAD, Chatchai WATTANAPIROMSAKUL   +2 more
doaj  

Ligand-based discovery of novel N-arylpyrrole derivatives as broad-spectrum antimicrobial agents with antibiofilm and anti-virulence activity

Journal of Enzyme Inhibition and Medicinal Chemistry
The escalating threat of antimicrobial resistance calls for novel therapeutic agents. This study employed a ligand-based design approach to develop three series of N-arylpyrrole derivatives (Va–e, VIa–e, and VIIa–e), refined through molecular modeling ...
Basma M. Qandeel, Samar Mowafy, Mohamed F. El-Badawy, Nahla A. Farag, Galal Yahya, Khaled Abouzid   +5 more
doaj   +1 more source

Effect of goat milk on hepatotoxicity induced by antitubercular drugs in rats [PDF]

, 2016
Aim of the present study was to assess the hepatoprotective activity of goat milk on antitubercular drug-induced hepatotoxicity in rats. Hepatotoxicity was induced in rats using a combination of isoniazid, rifampicin, and pyrazinamide given orally as a ...
Rakesh Raman Patyar, Sonam Miglani, Sazal Patyar, Patyar, Sazal, Patyar, Rakesh Raman, Reshi, Mohammad Rafi, Miglani, Sonam, Mohammad Rafi Reshi   +7 more
core   +1 more source

Screening of the antimycobacterial activity of novel lipophilic agents by the modified broth based method

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2016
Most of the introduced susceptibility methods of Mycobacterium tuberculosis have some disadvantages for screening. Therefore, the selection of susceptibility assay for evaluating candidate agents must be determined case by case.
Mehdi Zandhaghighi, Kiarash Ghazvini, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Saman Soleimanpour, Farzin Hadizadeh   +6 more
doaj   +1 more source

Efficient Mutasynthesis of “Non-Natural” Antitubercular Ilamycins with Low Cytotoxicity

Ilamycins are a type of cyclopeptide exhibiting potent antitubercular and cytotoxic activities, which make them promising leads for antitubercular and antitumor drugs with unique mechanisms.
Yingying Chen (500738), Yuyang Wang (494143), Md Shah Alam (4806219), Fang Wang (105926), Changli Sun (5522477), Zhuo Shang (1457281), Ziwen Lu (6643010), Jianqiao He (1593160), Yamin Gao (14326644), Tianyu Zhang (188439), Jianhua Ju (773073), Junying Ma (466656)   +11 more
core   +1 more source

Liver transplantation for acute liver failure due to antitubercular drugs – a single-center experience

Clinics, 2018
OBJECTIVES: Patients receiving treatment for tuberculosis are at risk of developing acute liver failure due to the hepatotoxicity of antitubercular drugs.
Rodrigo Bronze de Martino, Edson Abdala, Felipe Castro Villegas, Luiz Augusto Carneiro D’Albuquerque, Alice Tung Wan Song   +4 more
doaj   +1 more source

Synthesis and antitubercular activity of monocyclic nitroimidazoles: insights from econazole

, 2011
We have designed and synthesized econazole-derived nitroimidazoles to investigate the antitubercular activity of the nitroimidazole compounds. The introduction of a nitro group at the 4-position of the imidazole on econazole abolished the antitubercular ...
오태권, 조상래
core   +1 more source