Results 71 to 80 of about 26,304 (200)

Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents

, 2012
A series of fused and functionalized pyridine derivatives were designed, synthesized and tested for their potential antitubercular properties. All these novel compounds were prepared by using multistep methods involving the construction of pyridine ring ...
Kapavarapu, Ravikumar, Reiser, Oliver, Wan, Baojie, Iqbal, Javed, Pal, Manojit, Dulla, Balakrishna, Franzblau, Scott G.   +6 more
core   +1 more source

Atypical clinical and imaging manifestation in neurocysticercosis

Annals of Indian Academy of Neurology, 2011
A 20-year-old man presented with left-sided headache and seizures of three years duration. Conglomerate ring-enhancing lesions were seen in the first magnetic resonance imaging study. He was initially treated with anticonvulsants for two years.
L Dayananda, C Kesavadas, Bejoy Thomas, R Neelima, V V Radhakrishnan   +4 more
doaj   +1 more source

Synthesis and antitubercular activity of monocyclic nitroimidazoles: insights from econazole

, 2011
We have designed and synthesized econazole-derived nitroimidazoles to investigate the antitubercular activity of the nitroimidazole compounds. The introduction of a nitro group at the 4-position of the imidazole on econazole abolished the antitubercular ...
오태권, 조상래
core   +1 more source

PYRAZINAMIDE INDUCED ACUTE GOUTY ARTHRITIS

Journal of Nepal Medical Association, 2003
A typical case of pyrazinamide induced acute gouty arthritis in a tuberculous patient with antitubercular therapy including pyrazinamide was reported.
U N Pathak, B O Shrestha, R R Shrestha
doaj   +1 more source

Evaluation of antitubercular drug insertion into preformed dipalmitoylphosphatidylcholine monolayers

, 2008
Insertion profiles of antitubercular drugs isoniazid (INH), rifampicin (RFM) and ethambutol (ETH) into dipalmitoylphosphatidylcholine (DPPC) membrane models were evaluated by Langmuir monolayer technique.
CHIMOTE, G, BANERJEE, R
core   +1 more source

Ligand-based discovery of novel N-arylpyrrole derivatives as broad-spectrum antimicrobial agents with antibiofilm and anti-virulence activity

Journal of Enzyme Inhibition and Medicinal Chemistry
The escalating threat of antimicrobial resistance calls for novel therapeutic agents. This study employed a ligand-based design approach to develop three series of N-arylpyrrole derivatives (Va–e, VIa–e, and VIIa–e), refined through molecular modeling ...
Basma M. Qandeel, Samar Mowafy, Mohamed F. El-Badawy, Nahla A. Farag, Galal Yahya, Khaled Abouzid   +5 more
doaj   +1 more source

Investigation of Antitubercular and Cytotoxic Activities of Fruit Extract and Isolated Compounds from Piper retrofractum Vahl

Walailak Journal of Science and Technology, 2016
A bioassay guided fractionation procedure used on the crude methanol extract of Piper retrofractum fruit identified 4 compounds: piperine, methyl piperate, sylvatine, and piperlonguminine.
Saranya AMAD, Supreeya YUENYONGSAWAD, Chatchai WATTANAPIROMSAKUL   +2 more
doaj  

Structural isomerisation affects the antitubercular activity of adamantyl-isoxyl adducts

Journal of Enzyme Inhibition and Medicinal Chemistry
Despite efforts to discover effective treatments to eradicate tuberculosis (TB), it remains a global threat. The increase in drug-resistant bacterial species has made the discovery of new drugs highly coveted.
Yucheng Lu, Daniel Partleton, Filibus M. Gugu, Ahmed Y. G. Alhejaili, Samuel Norris, J. Jonathan Harburn, Jason H. Gill, Jonathan D. Sellars, Alistair K. Brown   +8 more
doaj   +1 more source

Histomorphological features of combined forms of tuberculosis and lung cancer [PDF]

Medičnì Perspektivi, 2017
The were studied pathological features of combined forms of tuberculosis and non-small cell lung cancer in 72 patients who underwent radical surgical resection interventions from transsternal access with mediastinal lymph node dissection, with ...
Savenkov Y.F., Koshak Y.F., Malcev I.A., Korpusenko I.V., Bakulin P.E.   +4 more
doaj  

Synthesis, antitubercular evaluation and molecular docking studies of phthalimide bearing 1,2,3-triazoles

, 2019
In a search for safer and potent antitubercular agents, here a library of newly substituted dioxoisoindolinylmethyl-triazolyl-N-phenylacetamide derivatives (5a–l) has been synthesized via click chemistry approach. All synthesized compounds were evaluated
Lalita K. Dahiwade (6706424), Prafulla B. Choudhari (6706427), Rajubai D. Bakale (6706421), Pramod S. Phatak (6706418), Sambhaji T. Dhumal (6276344), Kishan P. Haval (2420878), Dharmarajan Sriram (816698), Vagolu Siva Krishna (6706430)   +7 more
core   +1 more source