Results 21 to 30 of about 1,577,899 (206)

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues [PDF]

, 2013
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis ...
Vialla, Emilie, Gannoun-Zaki, Laila, Kremer, Laurent, Craig, Derek, Coxon, Geoffrey, Corrales, Rosa Milagros   +5 more
core   +5 more sources

PYRAZOLINES AS POTENT ANTITUBERCULAR AND CYTOTOXIC AGENTS [PDF]

, 2017
Objective: Pyrazolines are known to exhibit different biological and pharmacological properties such as anticancer, antibacterial, antifungal and antitubercular activities.
K, Ishwar Bhat, Kumar, Abhishek
core   +3 more sources

Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study

Journal of Nepal Medical Association, 2021
Introduction: Sputum non-conversion is smear positive tuberculosis despite anti-tubercular therapy. Various factors may lead to sputum non-conversion including resistance to anti-tubercular drugs, age, gender, disease severity, non-compliance, drugs ...
Naveen Prakash Shah, Anil Regmi, Aakash Acharya, Jwala K.C. , Bidur Khatiwada, Meera Hada   +5 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Identification of Better Pharmacokinetic Benzothiazinone Derivatives as New Antitubercular Agents [PDF]

ACS Medicinal Chemistry Letters, 2017
Xuefu You, Kai Lv, Mingliang Liu
exaly   +2 more sources

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

Pathogens, 2018
Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure
Davide M. Ferraris, Riccardo Miggiano, Franca Rossi, Menico Rizzi   +3 more
doaj   +1 more source

Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents

Pharmaceuticals, 2020
This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose de Leon   +3 more
doaj   +1 more source

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2014
The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB bacilli.
Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee   +12 more
doaj   +1 more source

A rare case of tuberculosis spine on antitubercular drug succumbing to pseudomembranous enterocolitis

Journal of Dr. NTR University of Health Sciences, 2021
Anti-tubercular therapy (ATT) drugs are the mainstay of management of tuberculosis worldwide. These medicines are used extensively across the globe in treating tubercular infections of any organ.
Simarjit S Rehsi, Nilanjan Roy, Vipin V Nair, Ajay K Baranwal, Prashant Sengupta, Pawan Sharma, Aman Kumar   +6 more
doaj   +1 more source

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

Journal of Taibah University for Science, 2019
We initiated a program to synthesize thiazolidinone derivatives as antitubercular agent by preparing hybrid molecules having the similar features of reported potent antitubercular agents.
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate   +6 more
doaj   +1 more source