Results 41 to 50 of about 1,577,899 (206)

Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin

Case Reports in Gastroenterology, 2011
Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin.
Jeong Moon Choi, Hyung Hun Kim, Seun Ja Park, Moo In Park, Won Moon   +4 more
doaj   +1 more source

Discovery of dipiperidines as new antitubercular agents [PDF]

Bioorganic & Medicinal Chemistry Letters, 2010
As part of our ongoing research effort to develop new therapeutics for treatment of tuberculosis (TB), we synthesized a combinatorial library of 10,358 compounds on solid support using a pool-and-split technique and tested the resulting compounds for activity against Mycobacteriumtuberculosis. Structure-activity relationship (SAR) evaluation identified
Elena, Bogatcheva, Colleen, Hanrahan, Ping, Chen, Jacqueline, Gearhart, Katherine, Sacksteder, Leo, Einck, Carol, Nacy, Marina, Protopopova   +7 more
openaire   +2 more sources

Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents. [PDF]

PLoS ONE, 2016
The 2-aminothiazole series has anti-bacterial activity against the important global pathogen Mycobacterium tuberculosis. We explored the nature of the activity by designing and synthesizing a large number of analogs and testing these for activity against
Edward A Kesicki, Mai A Bailey, Yulia Ovechkina, Julie V Early, Torey Alling, Julie Bowman, Edison S Zuniga, Suryakanta Dalai, Naresh Kumar, Thierry Masquelin, Philip A Hipskind, Joshua O Odingo, Tanya Parish   +12 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture [PDF]

, 2022
Dimeric boronic acids kill Mycobacterium tuberculosis (Mtb) by targeting mycobacterial specific extracellular glycans, removing the requirement for a therapeutic agent to permeate the complex cell envelope.
Elizabeth Fullam, Guy, Collette S., Qiao Tang, Gibson, Matthew I.; id_orcid, Collette S. Guy, Matthew I. Gibson, Tang, Qiao, Gibson, Matthew I., Tomás, Ruben, M. F., Fullam, Elizabeth, Tomás, Ruben M. F., Ruben M. F. Tomás   +11 more
core   +1 more source

Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

Molecules, 2021
Background. The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Design, Synthesis, and Anti-mycobacterial Evaluation of New 3,5-Disubstituted-pyrazole-1-carbothioamides

Indonesian Journal of Chemistry, 2022
Two series of new 3,5-disubstituted-pyrazole-1-carbothioamides (4a-f and 5a-e) were designed and synthesized through condensation reaction between chalcones and thiosemicarbazides under alkaline condition via cyclocondensation reaction.
Kok Tong Wong, Hasnah Osman, Thaigarajan Parumasivam, Muhammad Solehin Abd Ghani, Mohd. Zaheen Hassan, Unang Supratman, Mohamad Nurul Azmi Mohamad Taib   +6 more
doaj   +1 more source

NMR‐Based Structural Elucidation of a New Dihydroisocoumarin and Related Polyketides From a Mangrove‐Derived Fusarium sp.

Magnetic Resonance in Chemistry, EarlyView.
Integration of bioactivity screening and LC–MS/MS metabolomics enabled the discovery of a new antibacterial dihydroisocoumarin from Fusarium sp. IQ‐1921. NMR‐based structural elucidation identified five related metabolites, with the new compound 1 showing the broadest activity against multidrug‐resistant bacteria. ABSTRACT Antimicrobial resistance (AMR)
Evelyn García‐Oceguera, Carlos A. Fajardo‐Hernández, Ixchel A. Loa‐Ramírez, Jesús I. Morales‐Jiménez, José Rivera‐Chávez   +4 more
wiley   +1 more source

DEVELOPMENT OF NEW PYRAZOLE HYBRIDS AS ANTITUBERCULAR AGENTS: SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDY [PDF]

, 2017
Objective: synthesis of new 1, 3-diphenyl pyrazole derivatives 9(a-f) and 10(a-f) using molecular hybridization approach for antitubercular and cytotoxic studies.Methods: The structures of synthesized compounds were confirmed by 1H-NMR, 13C-NMR and mass ...
Zaheer, Zahid, Lokwani, Deepak K., Mokale, Santosh N., Shaikh, Sameer I.   +3 more
core   +3 more sources