Results 51 to 60 of about 1,577,899 (206)

Design of potent fluoro-substituted chalcones as antimicrobial agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Owing to ever-increasing bacterial and fungal drug resistance, we attempted to develop novel antitubercular and antimicrobial agents. For this purpose, we developed some new fluorine-substituted chalcone analogs (3, 4, 9–15, and 20–23) using a structure ...
Serdar Burmaoglu, Oztekin Algul, Arzu Gobek, Derya Aktas Anil, Mahmut Ulger, Busra Gul Erturk, Engin Kaplan, Aylin Dogen, Gönül Aslan   +8 more
doaj   +1 more source

Hepatitis C virus infection: a challenge in the complex management of two cases of multidrug-resistant tuberculosis

BMC Infectious Diseases, 2019
Background Multidrug-resistant tuberculosis (MDR-TB) requires lengthy use of second-line drugs, burdened by many side effects. Hepatitis C virus (HCV) chronic infection increases risk of drug-induced liver injury (DILI) in these patients.
Maria Musso, Silvia Mosti, Gina Gualano, Paola Mencarini, Rocco Urso, Piero Ghirga, Alessia Rianda, Franca Del Nonno, Delia Goletti, Fabrizio Palmieri   +9 more
doaj   +1 more source

Quinoxaline–Triazole Hybrids: Exploring the Impact of Substituent Architecture on Cytotoxic Potency and Receptor Interaction

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha, Mandapalli Sreeshitha, Shaik Farheen Banu, Kamala Prasad Vasikarla, Satyanarayana Swamy Vyshnava, Mukhriddin Makhkamov, Parthiban Marimuthu, Jamoliddin Razzokov, Aminul Islam, Peddiahgari Vasu Govardhana Reddy   +9 more
wiley   +1 more source

Synthesis of New Amide Linked Biphenoloxy 1,2,3-Triazoles as Antitubercular and Antimicrobial Agents

, 2023
New 1,2,3-triazoles bearing biphenoloxymethyl and acetanilido moieties (5a-5l) have been synthesized, starting from 4-phenylphenol (1) following click chemistry approach.
Ramrao A. Mane (3666052), Tejshri R. Deshmukh (8051162), Vijay M. Khedkar (554344), Sambhaji T. Dhumal (6276344), Kishan P. Haval (2420878), Prashant P. Dixit (7904240), Dharmarajan Sriram (816698), Naziya N. M. A. Rehman (7904237), Vagolu Siva Krishna (6706430)   +8 more
core   +1 more source

Design, Synthesis, and Biological Evaluation of Molecular Hybrids Incorporating Coumarin‐Pyrazole‐Linked Indolinone Derivatives With Antioxidant and Anti‐Alzheimer Properties

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
ABSTRACT The increase in global life expectancy has resulted in a significant rise in the occurrence of Alzheimer's disease (AD), making it a critical public health burden. Therefore, there is an urgent need to create effective methods to prevent or slow down the progression of the disease.
Ahmed Sabt, Wael Mahmoud Aboulthana, Abdulrahman M. Saleh, Hoda Atef Abdelsattar Ibrahim, Asmaa Saleh, Xinsheng Lei, Aladdin M. Srour   +6 more
wiley   +1 more source

Management of Hepatotoxicity and Utilization of Antitubercular Drugs in Chronic Liver Disease: A Narrative Review

Journal of Nepal Medical Association
The World Health Organization’s “End TB strategy” envisions a world free of tuberculosis (TB), emphasizing early diagnosis, effective treatment, and prevention.
Pratap Sagar Tiwari, Pukar Thapa
doaj   +1 more source

Nitrogen‐Doped Mesoporous Carbon Loaded With Zn Single Atoms as a Catalyst for the Synthesis of 2,4(5)‐Diarylimidazoles

ChemistryOpen, Volume 15, Issue 11, November 2026.
A zinc single‐atom catalyst anchored on nitrogen‐doped mesoporous carbon (Zn@NMC) was synthesized via an evaporation‐induced self‐assembly method and applied in the one‐pot synthesis of 2,4(5)‐diarylimidazoles. The catalyst was fully characterized using FT‐IR, XRD, SEM, EDX, BET, and TGA analyses.
Maryam Shojaei‐Asl, Mohsen Moradian
wiley   +1 more source

The Plasma, Whole Blood and Intracellular Concentrations of Antiretroviral Agents in South African Children Receiving Combination Antiretroviral Therapy with and without Concomitant Antitubercular Treatment [PDF]

, 2009
Background: Tuberculosis (TB) is the most common opportunistic infection in children with human immunodeficiency virus (HIV) infection in developing countries, and co-treatment for HIV infection and TB is frequently indicated.
Ren, Yuan
core   +1 more source

Incidence, Diagnosis and Treatment of Otorhinolaryngological, Head and Neck Tuberculosis: A Prospective Clinical Study

International Archives of Otorhinolaryngology, 2023
Introduction Tuberculosis is a disease of diversified presentation. It affects almost all organs in the body, and otorhinolaryngological, head and neck involvement is not an exception.
Biban Chhabra, Pratibha Vyas, Priyanshi Gupta, Prateek Sharma, Kanika Sharma   +4 more
doaj   +1 more source

Synthesis, Characterization, and In Vitro Evaluation of New Amino‐Alcohol Quinolines as Promising Antimycobacterial Agents

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Nontuberculous mycobacteria (NTM) mainly Mycobacterium avium complex (MAC), are emerging pathogens responsible for pulmonary infections. The efficacy of the standard treatment is therefore compromised by the emergence of intrinsic and acquired resistance in MAC.
Elise Si Ahmed Charrier, François Peltier, Jean‐François Raimbert, Marie Perret, Claire Andréjak, Alexandra Dassonville‐Klimpt, Pascal Sonnet   +6 more
wiley   +1 more source