Results 61 to 70 of about 1,577,899 (206)

4‐Thiazolidinone/2,4‐Thiazolidinedione–Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma, Andressa Francielli Bonjorno, Sukhwant Singh, Christian S. Carnero Canales, Jean Leandro dos Santos, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan   +6 more
wiley   +1 more source

Novel 1,4-substituted-1,2,3-triazoles as antitubercular agents.

, 2023
Tuberculosis (TB) remains a pressing unmet medical need, particularly with the emergence of multidrug-resistant and extensively drug-resistant tuberculosis.
Luke Henderson (13082367), Jarrad Altimari (13057848), A Sajid (13410789), Samantha Hockey (13093608), H I Boshoff (13687393)   +4 more
core  

Primary nasal tuberculosis: A case report [PDF]

Vojnosanitetski Pregled, 2013
Introduction. During the past two decades, tuberculosis (TBC) both pulmonary and extrapulmonary, has emerged to be a major health problem. Nasal tuberculosis is a specific inflammatory process which is, in most cases, joined by the inflammation of ...
Stojanović Jasmina, Belić Branislav, Mitrović Slobodanka, Stanković Predrag, Stojanović Stevan, Erdevički Ljiljana, Živić Ljubica, Arsenijević Snežana   +7 more
doaj   +1 more source

Imidazo[1,2‐b]Pyrazole‐1,2,4‐oxadiazole Linked 1,2,3‐Triazoles: Synthesis, Antibacterial, Biofilm, and In Silico Studies

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A collection of innovative imidazo[1,2‐b]pyrazole–1,2,4‐oxadiazole–1,2,3‐triazole hybrids was conceived via the molecular hybridization of bioactive pharmacophores and produced via a CuAAC methodology. The synthesized compounds exhibited strong antibacterial and antibiofilm properties against gram‐positive bacteria.
Suresh Kumar Murahari, Kavitha Siddoju
wiley   +1 more source

Integrated Biological Evaluation of Benzimidazolium–Chalcone Derivatives: Antioxidant, Anti‐AChE, Anticancer, and Anti‐MRSA Activities With Docking Insights

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Four benzimidazolium–chalcone derivatives were synthesized and explored for their multifunctional biological activities. The compounds exhibit distinct antioxidant, AChE inhibitory, antibacterial, antibiofilm, and apoptotic activities, supported by molecular docking analysis.
Mehmet Çimentepe, Hakan Ünver, Adem Necip, Mehmet Ersatir, Burcu Demirbağ, Özge Öztürk Çimentepe, Metin Yildirim   +6 more
wiley   +1 more source

Builiding a pharmacophore model for a novel class of antitubercular compounds

, 2000
Starting from a set of 32 antitubercular compounds, for the first time a three-dimensional pharmacophore model has been derived through a computational approach based on catalyst software.
Fioravanti, R., BOTTA M., Porretta, G. C., FIORAVANTI, Rossella, Manetti, Fabrizio, G.C Porretta, Corelli, Federico, PORRETTA, Giulio Cesare, MANETTI F., Botta, Maurizio, R Fioravanti, F Corelli*, CORELLI F., BIAVA, Mariangela, Biava, M., F Manetti, M Biava, M Botta*   +17 more
core   +1 more source

Structure‐Based Design and Biological Evaluation of Imidazo[1,2‐a]pyridine Derivatives as Potential Antituberculosis Agents

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A library of 11 novel imidazopyridine‐based sulfonamide derivatives (4a–4k) were synthesized through the coupling of an imidazo[1,2‐a]pyridine hydrochloride intermediate with various substituted arylsulfonyl chlorides (3a–3k). The synthesized derivatives (4a–4k) were subsequently evaluated for their antitubercular and antioxidant potential.
Hanmant N. Chaugule, Shravan Y. Jadhav, Sujay A. Ghorpade, Dayanand C. Kore, Vaibhav R. Mane, Umakant M. Kadampalle, Vijay H. Masand, Magdi E. A. Zaki, Rohit S. Bavi, Samin A. Shaikh   +9 more
wiley   +1 more source

Synthesis and Biological Evaluation of 2-(3-Fluoro-4-nitro phenoxy)-N-phenylacetamide Derivatives as Novel Potential Affordable Antitubercular Agents

Molecules, 2012
A novel series of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide compounds were designed, synthesized and in vitro assessed for their antitubercular activities by a microdilution method.
Yu-Quan Wei, Tao Yang, Jian-Zhong Yang, Wei-Yi Pi, Ying-Hong Yang, You-Fu Luo, Yong Deng, Yan-Ni Lin, Wei Ang   +8 more
doaj   +1 more source

Green Acid Mediated Synthesis of Imidazo[1,2‐a]Pyrimidine–Thiazole/1,3,4‐Thiadiazole Hybrids: Design, Characterization and In‐Vitro Biological Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A new set of imidazo[1,2‐a]pyrimidine‐thiazole/thiadiazole hybrids were developed through the molecular hybridization concept. The thiazole and thiadiazole derivatives were synthesized using water as a solvent, and the final compounds were synthesized using citric acid as an eco‐friendly catalyst.
Dinesha P, Shivakumar Naik, Udayakumar D, Maithilee S. Dhekale, Sampat Parayya Vibhutimath, Rajkumar Reddy Rajula, Revanasiddappa B.C, Nanditha Bhat, Naveena S. Veeranagaiah   +8 more
wiley   +1 more source

Paradoxical Deterioration During Anti-Tuberculous Therapy in Non-HIV-Infected Patients with Pleural Tuberculosis: A Pragmatic Approach

European Journal of Case Reports in Internal Medicine, 2016
We report a case of paradoxical deterioration. A male patient diagnosed with pleural tuberculosis, but who was not infected with human immunodeficiency virus (HIV), experienced clinical deterioration 3 weeks after the initiation of anti-tuberculous ...
Luis Corral-Gudino, Alicia Rivas-Lazamares, Ana Gonzalez-Fernandez, Juan Carlos Hernando-Garcia   +3 more
doaj   +1 more source