Results 81 to 90 of about 3,707,085 (259)

New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum [PDF]

, 2018
Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs.
A Gómez-Zavaglia, A Ismael, A Ismael, A Paulo, A Siriwardana, AM Dondorp, AM Dondorp, António Sebastião Rodrigues, B Weniger, B Witkowski, B Witkowski, Bruno Guerreiro, C Amaratunga, C Amaratunga, D Ménard, EA Ashley, ES Schaffert, F Ariey, F Nogueira, F Teuscher, Fatima Nogueira, FG Baptista, H Noedl, H Noedl, H Singh, HM Ismail, I Fernández, J Adamec, J Jourdan, J Straimer, J Straimer, J Straimer, J Straimer, JL Vennerstrom, K Chauhan, K Chauhan, K Chotivanich, KM Tun, L Lobo, LH Carvalho, Lis Lobo, Lília I. L. Cabral, M Drąg-Zalesińska, M Machado, M Mota, M Tukulula, MA Fügi, Maria Inês Sena, Maria L. S. Cristiano, MD Spring, N Thuy-Nhien, NCP Araújo, PB Mohite, PM O’Neill, PN Soh, RJ Herr, RS Upadhayaya, S Arulmurugan, S Chaorattanakawee, S Nwaka, S Takala-Harrison, S Takala-Harrison, SA Santos, SD Fontaine, T Yang, TNC Wells, Valter Ferreira de Andrade-Neto, VS de Sena Pereira, W Peters, WA Kite, World Health Organization, X Fan, Y Lubell, Y Tang, Z Li, Z Wang   +75 more
core   +2 more sources

Antitubercular Activity of Mushrooms (Basidiomycetes) and their Metabolites

Natural Product Communications, 2007
Re-emergence of multi-drug resistant and HIV-associated tuberculosis justifies the search for new anti-TB agents. Mushrooms (Basidiomycetes) and their secondary metabolites are relatively little explored in this respect.
Jordan K. Zjawiony
doaj   +1 more source

Comprehensive Analysis of Structure Activity Relationships in Quinoxaline Derivatives Covering Antimicrobial Applications

ChemistrySelect, Volume 11, Issue 14, 13 April 2026.
ABSTRACT Antimicrobial resistance (AMR) has emerged as one of the most critical global health challenges, undermining the clinical efficacy of existing antibiotics and threatening modern therapeutic strategies. The ongoing misuse and overuse of antimicrobial agents have accelerated the evolution of resistant bacterial strains and parasites ...
Subham Kumar Vishwakarma, Fernando Rogério Pavan, Cesar Augusto Roque‐Borda   +2 more
wiley   +1 more source

Defining the optimal dose of rifapentine for pulmonary tuberculosis: Exposure-response relations from two phase II clinical trials. [PDF]

, 2017
Rifapentine is a highly active antituberculosis antibiotic with treatment-shortening potential; however, exposure-response relations and the dose needed for maximal bactericidal activity have not been established.
Dooley, KE, Dorman, SE, Engle, M, Johnson, JL, MacKenzie, WR, Nahid, P, Nguyen, NV, Nsubuga, P, Peloquin, CA, Savic, RM, Tuberculosis Trials Consortium of the Centers for Disease Control and Prevention, Weiner, M, Whitworth, WC   +12 more
core   +1 more source

Antitubercular therapy decreases nitric oxide production in HIV/TB coinfected patients [PDF]

, 2002
Background: Nitric oxide (N) production is increased among patients with human immunodeficiency virus (HIV) infection and also those with tuberculosis ( B).
A Wanchu, A Bhatnagar, M Khullar, A Sud, P Bambery, S Singh, JL Jimenez, KD Kroncke, S Moncarda, A Wanchu, A Wanchu, A Wanchu, A Wanchu, HHW Schmidt, R Zangerle, E Hermann, A Wanchu, TG Evans, CH Wang, CH Wang, M Garcia, JB Mannick, J Gonzalez-Nicolas, R Zangerle, PA Selwyn, A Wanchu, T Schon, LC Green, TR Boyde, FP Huang, E Moilanen, HM Lander, SM Williams, AS Fauci, G Giovannoni, D Torre, D Torre, R Long, K Yu, JD MacMiking, A Bergamini, VP Mohan, C Immanuel, C Nathan, C Calleja   +44 more
core   +1 more source

Synthesis and biological evaluation of copper and cobalt complexes of (5-substituted-salicylidene) isonicotinichydrazide derivatives as antitubercular agents

, 2020
Cobalt(II) and copper(II) complexes of a series (E)-N’-(5-X-salicylidene)isonicotinohydrazide Schiff bases derived from isonicotinic acid hydrazide and 5-substituted-salicylaldehydes have been synthesized and characterized by FTIR, AAS, UV-Visible ...
C. U. Dueke‑Eze, T. M. Fasina, Abimbola E. Oluwalana, O. Familoni, J. M. Mphalele, C. Onubuogu   +5 more
semanticscholar   +1 more source

Nucleophilic substitution of a phthalimidyl group with morpholine in an N1‐methyl‐1,2,3‐triazole: crystallographic evidence for migration of the methylene bridge

Acta Crystallographica Section C, Volume 82, Issue 4, Page 144-150, April 2026.
X‐ray crystallography revealed that the reaction of 2‐{[4‐(4‐bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide with morpholine led to substitution of the phthalimide group, including migration of the substituent from N1 to N2 on the 1,2,3‐triazole ring.2‐{[4‐(4‐Bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide, C17H11BrN4O, was synthesized by ...
Paul R. Palme, Richard Goddard, Markus Leutzsch, Adrian Richter, Peter Imming, Rüdiger W. Seidel   +5 more
wiley   +1 more source

Natural carriers for application in tuberculosis treatment [PDF]

, 2012
Tuberculosis remains the leading cause of preventable deaths worldwide and unsuccessful therapy is mainly due to non-compliance with very prolonged treatments, often associated with severe side-effects.
Ahmad Z, Ahmad Z, Ahmad Z, Ahmad Z, Ahmad Z, Ahsan F, Ain Q, Al-Qadi S, Ana Grenha, Anwunobi A, Armstead A, Attama A, Azarmi S, Barrow W, Beneke C, Blasi P, Borges O, Braz L, Devi N, Doherty T, Dyala’A GG, Florence A, George M, Grabovac V, Grenha A, Grenha A, Hans M, Hugo Costa, Hunter RL, Hwang SM, Lehr C-M, Lewis C, Liu Z, Lu E, Malafaya P, Martins S, Misra A, Mizoe T, Mizrahy S, Mosser D, Murata Y, Pandey R, Pandey R, Pandey R, Pinto Reis C, Ranjita S, Russell D, Smola M, Sudhakar Y, Taylor P, Yadav AB, Zara GP   +51 more
core   +1 more source

Paradoxical Deterioration During Anti-Tuberculous Therapy in Non-HIV-Infected Patients with Pleural Tuberculosis: A Pragmatic Approach

European Journal of Case Reports in Internal Medicine, 2016
We report a case of paradoxical deterioration. A male patient diagnosed with pleural tuberculosis, but who was not infected with human immunodeficiency virus (HIV), experienced clinical deterioration 3 weeks after the initiation of anti-tuberculous ...
Luis Corral-Gudino, Alicia Rivas-Lazamares, Ana Gonzalez-Fernandez, Juan Carlos Hernando-Garcia   +3 more
doaj   +1 more source

Synthesis, Biological Evaluation, and Theoretical Study of Indenoquinolinylphosphine Oxide Derivatives as Topoisomerase 1 Inhibitors and Antiproliferative Agents

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
The topoisomerase I inhibition and antiproliferative activities of phosphorated indenoquinoline derivatives were investigated. The target hybrid quinoline and tetrahydroquinoline compounds were synthesized via a two‐step Povarov‐type cycloaddition.
Alba Rodriguez, Elena Formoso, Birgitta R. Knudsen, Cinzia Tesauro, Maria Fuertes, Concepcion Alonso   +5 more
wiley   +1 more source