Results 91 to 100 of about 1,577,899 (206)

Identification of Axinellamines A and B as Anti-Tubercular Agents

Marine Drugs
Tuberculosis remains a significant global health pandemic. There is an urgent need for new anti-tubercular agents to combat the rising incidence of drug resistance and to offer effective and additive therapeutic options.
Emily J. Strong, Lendl Tan, Sasha Hayes, Hayden Whyte, Rohan A. Davis, Nicholas P. West   +5 more
doaj   +1 more source

Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity

Nitroarenes are less preferred in drug discovery due to their potential to be mutagenic. However, several nitroarenes were shown to be promising antitubercular agents with specific modes of action, namely, nitroimidazoles and benzothiazinones.
Sambandamurthy, Vasan K., Vachaspati, Prakash, Balasubramanian, V., Guptha, Supreeth, Ramachandran, Vasanthi, Murugan, Kannan, Kumar, Anupriya, Sadler, Claire, Ugarkar, Bheemarao G., Panda, Manoranjan, Balganesh, Tanjore S., Bandodkar, Balachandra S., Neres, Joao, Ravishankar, Sudha, Sharma, Sreevalli, Raichurkar, Anandkumar, Humnabadkar, Vaishali, Landge, Sudhir, Fellows, Mick D.   +18 more
core   +1 more source

Identification of 1‑[4-Benzyloxyphenyl)-but-3-enyl]‑1H‑azoles as New Class of Antitubercular and Antimicrobial Agents

, 2016
A series of 1-[(4-benzyloxyphenyl)-but-3-enyl]-1H-azoles has been identified as potent antitubercular agents against Mycobacterium tuberculosis. Synthesis of compounds involved acid catalyzed ring-opening of cyclopropyl ring of phenyl cyclopropyl ...
Rama Pati Tripathi (13205), Brijesh Kumar (414516), Munna P. Gupt (1900498), Shailandra K. Pandey (1900507), A. K. Dwivedi (1900495), Kishore K. Srivastava (1580323), Prapunjika Sharma (1900510), Praveen K. Shukla (1900501), Varsha Gupta (615474), Shubhra Singh (1900513), Niyati Rai (676586), Vinita Chaturvedi (1508260), Jawahar Lal (1738096), Namrata Anand (658448), Smriti Pandey (1900516), K. K. G. Ramakrishna (1900504), Ravishankar Ramachandran (13206)   +16 more
core   +1 more source

Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies

, 2009
A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25microg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M.
Vinod, Kumar, Delogu, Giovanni, Gemma, Sandra, Camodeca, Caterina, Altarelli, Maria, Chiasserini, Luisa, Tripaldi, Pierangela, Savini, Luisa, Clarizio, Sandra, Butini, Stefania, Campiani, Giuseppe, Novellino, Ettore, Sanna Coccone, Salvatore, ALTARELLI M, NOVELLINO E, SAVINI L, BUTINI S, COCCONE S.S, GEMMA S, KUMAR V, DELOGU G, CHIASSERINI L, CAMODECA C, TRIPALDI P, CAMPIANI G, CLARIZIO S, Sandra Gemma, Giovanni Delogu, Maria Altarelli, Pierangela Tripaldi, Vinod Kumar, Sandra Clarizio, Luisa Chiasserini, Ettore Novellino, Caterina Camodeca, Luisa Savini, Salvatore Sanna Coccone, Giuseppe Campiani, Stefania Butini   +38 more
core   +1 more source

Phytogenic silver, gold, and bimetallic nanoparticles as novel antitubercular agents

International Journal of Nanomedicine, 2016
Richa Singh,1 Laxman Nawale,2 Manisha Arkile,2 Sweety Wadhwani,1 Utkarsha Shedbalkar,1 Snehal Chopade,1 Dhiman Sarkar,2 Balu Ananda Chopade1,3 1Department of Microbiology, Savitribai Phule Pune University, 2Combichem-Bioresource Center, Organic ...
Singh R, Nawale L, Arkile M, Wadhwani S, Shedbalkar U, Chopade S, Sarkar D, Chopade BA   +7 more
doaj  

Synthesis and Structure-Activity Relationships of a New Class of Oxadiazoles Targeting DprE1 as Antitubercular Agents. [PDF]

ACS Med Chem Lett, 2023
Yadav VD, Boshoff HI, Trifonov L, Roma JSO, Ioerger TR, Barry CE, Oh S.   +6 more
europepmc   +1 more source

Transferrin conjugates of antitubercular drug isoniazid: Synthesis and in vitro efficacy

, 2019
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) has become the world's leading killer disease due to a single infectious agent which survives in the host macrophage for the indefinite period. Hence, it is necessary to enhance the efficacy of
Singh, Amit, Telvekar, Vikas N, Mali, Jaishree K, Rajmani, Raju S, Sutar, Yogesh B   +4 more
core   +1 more source

Molecular docking and pharmacokinetics of benzimidazole-based FtsZ inhibitors for tuberculosis

Scientific Reports
Benzimidazole derivatives are privileged heterocyclic scaffolds with broad-spectrum pharmacological activities, notably antitubercular and antibacterial.
Pratiksha N. Sonwane, Manoj R. Kumbhare
doaj   +1 more source

Structure-directed identification of pyridine-2-methylamine derivatives as MmpL3 inhibitors for use as antitubercular agents. [PDF]

Eur J Med Chem, 2023
Wen Y, Lun S, Jiao Y, Zhang W, Liu T, Yang F, Tang J, Bishai WR, Yu LF.   +8 more
europepmc   +1 more source

4-[10-(Methoxy-benzyl)-anthracen-9-yl]-phenol derivatives as new antitubercular agents

ARKIVOC, 2005
Gautam Panda, Jitendra Kumar Mishra, Sudhir Sinha, Anil K. Gaikwad, Anil K. Srivastava, Ranjana Srivastava, Brahm S. Srivastava   +6 more
doaj   +1 more source