Results 31 to 40 of about 16,260 (178)

Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

Molecules, 2021
Background. The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Pellagra in Contemporary Clinical Practice (2000–2023): A Systematic Review

International Journal of Dermatology, Volume 65, Issue 8, Page 1590-1599, August 2026.
This systematic review (2000–2023) of 1212 cases highlights pellagra's evolving etiology. While primary dietary deficiency (85%) persists in humanitarian crises, secondary forms from alcohol misuse (9.6%), isoniazid (14.3% of drug‐related cases), and malabsorption are rising.
Noureddine Litaiem, Karama Sboui, Faten Zeglaoui   +2 more
wiley   +1 more source

Investigating the Inhibitory Properties of Diazo and Pyrazole‐Carboxamide‐Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Hybrid diazo‐ and pyrazole‐carboxamide benzenesulfonamides emerge as highly potent and selective inhibitors of tumor‐associated carbonic anhydrases. A 3,4‐dichloro‐substituted derivative achieves sub‐2 nM inhibition of hCA IX and displays promising anticancer activity, revealing a valuable scaffold for the development of next‐generation cancer‐targeted
Suleyman Akocak, Nebih Lolak, Andrea Ammara, Gökçenur Gürbüz, Ibrahim Bozgeyik, Demet Taşdemir, Hamada Hashem, Stefan Bräse, Claudiu T. Supuran   +8 more
wiley   +1 more source

Hepatitis C virus infection: a challenge in the complex management of two cases of multidrug-resistant tuberculosis

BMC Infectious Diseases, 2019
Background Multidrug-resistant tuberculosis (MDR-TB) requires lengthy use of second-line drugs, burdened by many side effects. Hepatitis C virus (HCV) chronic infection increases risk of drug-induced liver injury (DILI) in these patients.
Maria Musso, Silvia Mosti, Gina Gualano, Paola Mencarini, Rocco Urso, Piero Ghirga, Alessia Rianda, Franca Del Nonno, Delia Goletti, Fabrizio Palmieri   +9 more
doaj   +1 more source

Design, Synthesis, and Anti-mycobacterial Evaluation of New 3,5-Disubstituted-pyrazole-1-carbothioamides

Indonesian Journal of Chemistry, 2022
Two series of new 3,5-disubstituted-pyrazole-1-carbothioamides (4a-f and 5a-e) were designed and synthesized through condensation reaction between chalcones and thiosemicarbazides under alkaline condition via cyclocondensation reaction.
Kok Tong Wong, Hasnah Osman, Thaigarajan Parumasivam, Muhammad Solehin Abd Ghani, Mohd. Zaheen Hassan, Unang Supratman, Mohamad Nurul Azmi Mohamad Taib   +6 more
doaj   +1 more source

Interplay Between Infectious Diseases and the Endocrine System: An Overview and Clinical Insights

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Infectious diseases can disrupt endocrine homeostasis through direct cytopathic injury, autoimmune dysregulation, or pathogen‐derived hormone‐like effects. Viruses and bacteria are the most frequent agents, whereas fungi and parasites contribute less commonly, even remaining clinically relevant, especially in the immunocompromised population.
Francesco Capoccia, Valentina D'Onghia, Valentina Semeraro, Esposito Susanna, Maria Elisabeth Street   +4 more
wiley   +1 more source

Management of Hepatotoxicity and Utilization of Antitubercular Drugs in Chronic Liver Disease: A Narrative Review

Journal of Nepal Medical Association
The World Health Organization’s “End TB strategy” envisions a world free of tuberculosis (TB), emphasizing early diagnosis, effective treatment, and prevention.
Pratap Sagar Tiwari, Pukar Thapa
doaj   +1 more source

Design of potent fluoro-substituted chalcones as antimicrobial agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Owing to ever-increasing bacterial and fungal drug resistance, we attempted to develop novel antitubercular and antimicrobial agents. For this purpose, we developed some new fluorine-substituted chalcone analogs (3, 4, 9–15, and 20–23) using a structure ...
Serdar Burmaoglu, Oztekin Algul, Arzu Gobek, Derya Aktas Anil, Mahmut Ulger, Busra Gul Erturk, Engin Kaplan, Aylin Dogen, Gönül Aslan   +8 more
doaj   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source