Results 31 to 40 of about 3,707,085 (259)

A rare case of tuberculosis spine on antitubercular drug succumbing to pseudomembranous enterocolitis

Journal of Dr. NTR University of Health Sciences, 2021
Anti-tubercular therapy (ATT) drugs are the mainstay of management of tuberculosis worldwide. These medicines are used extensively across the globe in treating tubercular infections of any organ.
Simarjit S Rehsi, Nilanjan Roy, Vipin V Nair, Ajay K Baranwal, Prashant Sengupta, Pawan Sharma, Aman Kumar   +6 more
doaj   +1 more source

Studies on new substituted pyridazinones: synthesis and biological evaluation

Brazilian Journal of Pharmaceutical Sciences, 2018
We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents.
Mohammad Asif, Anita Singh, Shah Alam Khan, Asif Husain   +3 more
doaj   +1 more source

Phenothiazines as a solution for multidrug resistant tuberculosis:From the origin to present [PDF]

, 2015
Historically, multiplicity of actions in synthetic compounds is a rule rather than exception. The science of non-antibiotics evolved in this background.
Christensen, Jørn B, Das, Sukhen, Dastidar, Sujata G, Hendricks, Oliver, Kristiansen, Jette E, Palchoudhuri, Shauroseni, Roy, Debalina Sinha   +6 more
core   +6 more sources

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

Journal of Taibah University for Science, 2019
We initiated a program to synthesize thiazolidinone derivatives as antitubercular agent by preparing hybrid molecules having the similar features of reported potent antitubercular agents.
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate   +6 more
doaj   +1 more source

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

Life Science Alliance, 2018
AN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis , good oral bioavailability, and comparable efficacy to isoniazid in infection models. New antitubercular agents are
Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, Tanya Parish, MRK Alley   +23 more
doaj   +1 more source

Data-mining of potential antitubercular activities from molecular ingredients of traditional Chinese medicines [PDF]

, 2014
Background. Traditional Chinese medicine encompasses a well established alternate system of medicine based on a broad range of herbal formulations and is practiced extensively in the region for the treatment of a wide variety of diseases. In recent years,
Baell, Bouckaert, Chang, Chen, Chen, Chen, Cheng, Choi, DiMasi, Fang, Han, Hann, Hu, Huth, Iinuma, Issabeagloo, Jaiswal, Jamal, Jamal, Jiang, Kurti, Li, Li, Li, Liu, Liu, Lu, Melville, Merget, Mohamed Saleem, Nader, Nair, Normile, Ooi, O’Boyle, Periwal, Periwal, Qiu, Rani, Sato, Schierz, Schneidman-Duhovny, Shah, Silva, Singla, Su, Sucher, Thattakudian Sheik Uduman, Udino, Vasanthanathan, Vert, Wagner, Wang, Wang, Wen, Xue, Yew, Zhang   +57 more
core   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Oral Provocation Testing in Cutaneous Adverse Drug Reactions to Antiretroviral and Antitubercular Therapy: A Study at a Tertiary Care Hospital in South India

Journal of the International Association of Providers of AIDS Care, 2018
Aim: To collect data pertaining to oral drug provocation testing (DPT) in hospitalized patients with antiretroviral (ARV)/antitubercular agent–induced rashes.
Sowmya Kaimal MBBS, MD, Jithendriya Madhukara MBBS, DVD, DNB   +1 more
doaj   +1 more source

Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-dimethylaminomethyl)phenyl)quinoline Derived Antitubercular Lead Compounds [PDF]

, 2016
Bedaquiline (BDQ) is a novel and highly potent last-line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo-structural complexity, chemical synthesis and compound optimization are rather difficult and expensive. This study
Cui, HC, Fu, LF, He, CH, Meier, TK, Preiss, LP, Wang, BW, Wen, HW, Yin, DY, Zhang, XZ   +8 more
core   +1 more source

The Value of Enzyme-linked Immunospot Assay in Identifying Causative Agents in Patients with Hypersensitivity Reactions to Antitubercular Agents [PDF]

Zhongguo quanke yixue
Background Hypersensitivity reactions of antitubercular agents are very common in clinical practice. Drug provocation test is the only effective method to find out the causative agents, but it may cause re-sensitization or even shock, which can be life ...
WU Yuqing, LIU Zhou, LIAO Yongmei
doaj   +1 more source