Results 31 to 40 of about 1,577,899 (206)

Studies on new substituted pyridazinones: synthesis and biological evaluation

Brazilian Journal of Pharmaceutical Sciences, 2018
We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents.
Mohammad Asif, Anita Singh, Shah Alam Khan, Asif Husain   +3 more
doaj   +1 more source

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

Life Science Alliance, 2018
AN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis , good oral bioavailability, and comparable efficacy to isoniazid in infection models. New antitubercular agents are
Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, Tanya Parish, MRK Alley   +23 more
doaj   +1 more source

Microbial glycosylation of antitubercular agent chlorflavonin

Journal of Bioscience and Bioengineering, 2023
Flavonoids have shown health-benefiting properties, such as antioxidative and anti-inflammatory activities, and are commonly used as nutraceuticals and pharmaceuticals. Although flavonoids are predominantly identified from plants, several filamentous fungal species have also been reported to produce bioactive flavonoids, including chlorflavonin from ...
Jie Ren, Jixun Zhan
openaire   +3 more sources

Design, Synthesis and Biological Evaluation of Novel Indole-2-Carboxamide Derivatives as Anti-Tubercular Agents [PDF]

, 2021
The thesis entails the design, synthesis and biological evaluation of novel small molecules as potential antitubercular and/or antitumour ...
Alsayed, Shahinda Sayed Rabie
core   +1 more source

Docking Simulations and Primary Assessment of Newly Synthesized Benzene Sulfonamide Pyrazole Oxadiazole Derivatives as Potential Antimicrobial and Antitubercular Agents

, 2022
A novel series of benzene sulfonamide pyrazole oxadiazole derivatives have been synthesized by reaction of 4-(5-(3-fluoro-4-methoxyphenyl)-3-(hydrazinecarbonyl)-1H-pyrazol-1-yl) benzene sulfonamide with different substituted benzoic/pyridinyl/indolyl ...
Yogesh Patil (1967308), Dhanji Rajani (12048941), Ramesh Shingare (12048935), Rajesh Patil (719896), Jaiprakash Sangshetti (12048938), Balaji Madje (12048944)   +5 more
core   +1 more source

The challenge of managing extensively drug-resistant tuberculosis at a referral hospital in the state of São Paulo, Brazil: a report of three cases [PDF]

Jornal Brasileiro de Pneumologia, 2015
Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test results,
Marcos Abdo Arbex, Hélio Ribeiro de Siqueira, Lia D'Ambrosio, Giovanni Battista Migliori   +3 more
doaj   +3 more sources

Colo‐appendico‐duodenal fistula: Rare presentation of extrapulmonary tuberculosis

Clinical Case Reports, 2021
A colo‐appendico‐duodenal fistula is a rare occurrence that results from extrapulmonary tuberculosis (TB) complications, especially in the endemic region.
David Eng Yeow Gan, Rohamini Sibin, Alvin Oliver Payus, Firdaus Hayati   +3 more
doaj   +1 more source

Identification of N-Benzyl 3,5-Dinitrobenzamides Derived from PBTZ169 as Antitubercular Agents. [PDF]

ACS Med Chem Lett, 2018
A series of benzamide scaffolds were designed and synthesized by the thiazinone ring opening of PBTZ169, and N-benzyl 3,5-dinitrobenzamides were finally identified as anti-TB agents in this work.
Li L, Lv K, Yang Y, Sun J, Tao Z, Wang A, Wang B, Wang H, Geng Y, Liu M, Guo H, Lu Y.   +11 more
europepmc   +2 more sources

Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamides

Chemistry Central Journal, 2018
Background The study describes the synthesis, characterization, in vitro antimicrobial and anticancer evaluation of a series of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamide derivatives. The synthesized derivatives were also assessed
Snehlata Yadav, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah, Abhishek Mathur, Balasubramanian Narasimhan   +6 more
doaj   +1 more source

Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities

Molecules, 2020
Infectious diseases caused by fungi and mycobacteria pose an important problem for humankind. Similarly, cancer is one of the leading causes of death globally.
Afzal B. Shaik, Richie R. Bhandare, Srinath Nissankararao, Zehra Edis, N. Ravikiran Tangirala, Shaik Shahanaaz, M. Mukhlesur Rahman   +6 more
doaj   +1 more source