Results 31 to 40 of about 17,370 (212)

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues

, 2013
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis ...
Derek Craig, Rosa Milagros Corrales, Craig Derek, Gannoun-Zaki, Laila, Geoffrey D Coxon, Laila Gannoun-Zaki, Laurent Kremer, Gannoun-Zaki Laila, Emilie Vialla, Herrmann, Jean Louis, Coxon, Geoffrey, Corrales, Rosa Milagros, Coxon Geoffrey D., Vialla, Emilie, Kremer Laurent, Kremer, Laurent, Corrales Rosa Milagros, Vialla Emilie, Craig, Derek   +18 more
core   +1 more source

Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin

Case Reports in Gastroenterology, 2011
Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin.
Jeong Moon Choi, Hyung Hun Kim, Seun Ja Park, Moo In Park, Won Moon   +4 more
doaj   +1 more source

Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents. [PDF]

PLoS ONE, 2016
The 2-aminothiazole series has anti-bacterial activity against the important global pathogen Mycobacterium tuberculosis. We explored the nature of the activity by designing and synthesizing a large number of analogs and testing these for activity against
Edward A Kesicki, Mai A Bailey, Yulia Ovechkina, Julie V Early, Torey Alling, Julie Bowman, Edison S Zuniga, Suryakanta Dalai, Naresh Kumar, Thierry Masquelin, Philip A Hipskind, Joshua O Odingo, Tanya Parish   +12 more
doaj   +1 more source

Current Progress in Differentiating Crohn's Disease From Intestinal Tuberculosis

iLABMED, EarlyView.
Currently, there are various methods from different fields used to differentiate Crohn's disease from intestinal tuberculosis (ITB). Endoscopic findings are an important cornerstone. They can be used individually or in combination (models) to demonstrate excellent discriminative ability.
Chuyao Zhang, Xiaoyin Zhang
wiley   +1 more source

Colo‐appendico‐duodenal fistula: Rare presentation of extrapulmonary tuberculosis

Clinical Case Reports, 2021
A colo‐appendico‐duodenal fistula is a rare occurrence that results from extrapulmonary tuberculosis (TB) complications, especially in the endemic region.
David Eng Yeow Gan, Rohamini Sibin, Alvin Oliver Payus, Firdaus Hayati   +3 more
doaj   +1 more source

Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

Molecules, 2021
Background. The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +1 more source

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

iMetaMed, EarlyView.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian, Shuyu Xie, Yanqing Tang, Junjie Liang, Wenhan Zhu, Tianqi Liu, Yewen Sun, Yang Yang, Luoxi Zhang, Danfeng Wang, Chuyao Lin, Jinyu Jia, Minjia Tan, Jun‐Yu Xu   +13 more
wiley   +1 more source

Identification of N-Benzyl 3,5-Dinitrobenzamides Derived from PBTZ169 as Antitubercular Agents. [PDF]

ACS Med Chem Lett, 2018
A series of benzamide scaffolds were designed and synthesized by the thiazinone ring opening of PBTZ169, and N-benzyl 3,5-dinitrobenzamides were finally identified as anti-TB agents in this work.
Li L, Lv K, Yang Y, Sun J, Tao Z, Wang A, Wang B, Wang H, Geng Y, Liu M, Guo H, Lu Y.   +11 more
europepmc   +2 more sources

DEVELOPMENT OF NEW PYRAZOLE HYBRIDS AS ANTITUBERCULAR AGENTS: SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDY

, 2017
Objective: synthesis of new 1, 3-diphenyl pyrazole derivatives 9(a-f) and 10(a-f) using molecular hybridization approach for antitubercular and cytotoxic studies.Methods: The structures of synthesized compounds were confirmed by 1H-NMR, 13C-NMR and mass ...
Zahid Zaheer, Santosh N. Mokale, Sameer I. Shaikh, Deepak K. Lokwani   +3 more
core   +2 more sources

Design, Synthesis, and Anti-mycobacterial Evaluation of New 3,5-Disubstituted-pyrazole-1-carbothioamides

Indonesian Journal of Chemistry, 2022
Two series of new 3,5-disubstituted-pyrazole-1-carbothioamides (4a-f and 5a-e) were designed and synthesized through condensation reaction between chalcones and thiosemicarbazides under alkaline condition via cyclocondensation reaction.
Kok Tong Wong, Hasnah Osman, Thaigarajan Parumasivam, Muhammad Solehin Abd Ghani, Mohd. Zaheen Hassan, Unang Supratman, Mohamad Nurul Azmi Mohamad Taib   +6 more
doaj   +1 more source