Results 1 to 10 of about 68,283 (287)

Thermodynamics of ABC transporters [PDF]

Protein & Cell, 2015
ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and
Xuejun C. Zhang, Lei Han, Yan Zhao
doaj   +5 more sources

ABC transporters: the power to change [PDF]

Nature Reviews Molecular Cell Biology, 2009
ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of integral membrane proteins that are responsible for the ATP-powered translocation of many substrates across membranes. The highly conserved ABC domains of ABC transporters provide the nucleotide-dependent engine that drives transport.
Douglas C Rees, Eric Johnson, Oded Lewinson   +2 more
exaly   +7 more sources

Clinical Significance of Lipid Transport Function of ABC Transporters in the Innate Immune System

Membranes, 2022
ABC transporters are a large family of proteins that transport a variety of substrates across cell plasma membranes. Because of this, they are involved in many physiological processes.
Stanislav Kotlyarov, Anna Kotlyarova, Kotlyarov Stanislav   +2 more
exaly   +3 more sources

Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma [PDF]

Pharmaceuticals
Background: The multiple drug-resistant phenomenon has long since plagued the effectiveness of various chemotherapies used in the treatment of patients with glioblastoma (GBM), which is still incurable to this day. ATP-binding cassette (ABC) transporters
Brandon Wee Siang Phon, Shalini Sundramurthi Chelliah, Dina El-Rabie Osman, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin   +5 more
doaj   +2 more sources

Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs [PDF]

Frontiers in Pharmacology
ATP-binding cassette (ABC) transporters are transmembrane proteins expressed commonly in metabolic and excretory organs to control xenobiotic or endobiotic disposition and maintain their homeostasis.
Yimei Wang, Mei-Juan Tu, Ai-Ming Yu
doaj   +2 more sources

Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System [PDF]

Cells
ATP-binding cassette (ABC) transporters play a crucial role for the efflux of a wide range of substrates across different cellular membranes. In the central nervous system (CNS), ABC transporters have recently gathered significant attention due to their ...
Maria Villa, Jingyun Wu, Stefanie Hansen, Jens Pahnke   +3 more
doaj   +2 more sources

ABC Transporters [PDF]

FEBS Letters, 2006
ABC transporters are proteins that are involved in the uptake of nutrients and excretion of harmful substances in biological cells. Defects in human ABC transporters can result in severe diseases. Too high ABC transporter activity can lead to non-responsiveness of cancercells to chemotherapy, and resistance of bacteria to antibiotics.
Flügge, U.I., van Meer, G.
  +8 more sources

Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters

Nature Communications
SbmA is a membrane transporter from Escherichia coli that imports antimicrobial peptides. SbmA belongs to the SbmA-like peptide transporter (SLiPT) family.
Thijs W. Ettema, Satomi Inaba-Inoue, Chancievan Thangaratnarajah, Leticia Alves da Silva, Nikas Senning, Amy Clarke, Piotr Stepien, Anokhi Shah, Yue Ma, Katie Hardman, Sophia David, Hassane El Mkami, Jonathan G. Heddle, Norimichi Nomura, Satoshi Ogasawara, So Iwata, Dmitry Ghilarov, Christos Pliotas, Thomas Stockner, Dirk J. Slotboom, Konstantinos Beis   +20 more
doaj   +2 more sources

DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network

Frontiers in Cell and Developmental Biology, 2021
ATP-binding cassette (ABC) transporters can promote cells to absorb nutrients and excrete harmful substances. It plays a vital role in the transmembrane transport of macromolecules.
Zhaoxi Zhang, Juan Wang, Juan Wang, Jiameng Liu   +3 more
doaj   +1 more source

Identification and Validation of Prognostic Related Hallmark ATP-Binding Cassette Transporters Associated With Immune Cell Infiltration Patterns in Thyroid Carcinoma

Frontiers in Oncology, 2022
ATP-binding cassette (ABC) transporters are a large superfamily of membrane proteins that facilitate the translocation of heterogeneous substrates. Studies indicate that ABC transporters may play important roles in various carcinomas.
Lidong Wang, Xiaodan Sun, Xiaodan Sun, Jingni He, Zhen Liu   +4 more
doaj   +1 more source