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ABC transporters: the power to change [PDF]
Nature Reviews Molecular Cell Biology, 2009 ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of integral membrane proteins that are responsible for the ATP-powered translocation of many substrates across membranes.
Douglas C Rees +2 more
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Clinical Significance of Lipid Transport Function of ABC Transporters in the Innate Immune System
Membranes, 2022 ABC transporters are a large family of proteins that transport a variety of substrates across cell plasma membranes. Because of this, they are involved in many physiological processes.
Станислав Котляров +1 more
exaly +3 more sources
Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma [PDF]
PharmaceuticalsBackground: The multiple drug-resistant phenomenon has long since plagued the effectiveness of various chemotherapies used in the treatment of patients with glioblastoma (GBM), which is still incurable to this day. ATP-binding cassette (ABC) transporters
Brandon Wee Siang Phon +5 more
doaj +2 more sources
Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs [PDF]
Frontiers in PharmacologyATP-binding cassette (ABC) transporters are transmembrane proteins expressed commonly in metabolic and excretory organs to control xenobiotic or endobiotic disposition and maintain their homeostasis.
Yimei Wang, Mei-Juan Tu, Ai-Ming Yu
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Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System [PDF]
CellsATP-binding cassette (ABC) transporters play a crucial role for the efflux of a wide range of substrates across different cellular membranes. In the central nervous system (CNS), ABC transporters have recently gathered significant attention due to their ...
Maria Villa +3 more
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DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network
Frontiers in Cell and Developmental Biology, 2021 ATP-binding cassette (ABC) transporters can promote cells to absorb nutrients and excrete harmful substances. It plays a vital role in the transmembrane transport of macromolecules.
Zhaoxi Zhang +3 more
doaj +1 more source
Frontiers in Oncology, 2022 ATP-binding cassette (ABC) transporters are a large superfamily of membrane proteins that facilitate the translocation of heterogeneous substrates. Studies indicate that ABC transporters may play important roles in various carcinomas.
Lidong Wang +4 more
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Sensitive and specific fluorescent probes for functional analysis of the three major types of mammalian ABC transporters. [PDF]
PLoS ONE, 2011 An underlying mechanism for multi drug resistance (MDR) is up-regulation of the transmembrane ATP-binding cassette (ABC) transporter proteins. ABC transporters also determine the general fate and effect of pharmaceutical agents in the body.
Irina V Lebedeva +2 more
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The impact of ATP-binding cassette transporters on metabolic diseases
Nutrition & Metabolism, 2020 Currently, many people worldwide suffer from metabolic diseases caused by heredity and external factors, such as diet. One of the symptoms of metabolic diseases is abnormal lipid metabolism.
Zixiang Ye, Yifei Lu, Tao Wu
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Microorganisms, 2021 ATP-binding cassette (ABC) transporters are usually involved in the translocation of their cognate substrates, which is driven by ATP hydrolysis. Typically, these transporters are required for the import or export of a wide range of substrates such as ...
Jeanine Rismondo, Lisa Maria Schulz
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