Results 1 to 10 of about 29,397 (197)
Acta Pharmaceutica Sinica B, 2021 Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due
Xu Wu +10 more
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Umbralisib antagonizes multidrug resistance in ABCB1-overexpressing cancer cells [PDF]
Frontiers in OncologyIntroductionABCB1-mediated multidrug resistance (MDR) reduces the intracellular accumulation of anticancer drugs and limits chemotherapy efficacy. This study investigated whether umbralisib, a dual PI3Kδ/CK1ϵ inhibitor, could reverse ABCB1-mediated MDR ...
Letao Bo +11 more
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Cloning, structural and functional characterization of the ABCB1 transporter of the Eurasian bullfinch (Pyrrhula pyrrhula) [PDF]
Frontiers in Veterinary ScienceSuspected ivermectin hypersensitivity has been reported in the Eurasian bullfinch and some related passerine birds. However, the underlying cause and pharmacological mechanism have not been systematically investigated.
Katharina Heilmann +5 more
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Distribution of ABCB1 Genetic Variants and their Association with Moxifloxacin Pharmacokinetics in Hospitalized Patients with Acute Exacerbation of COPD [PDF]
Balkan Journal of Medical GeneticsInterindividual variability in moxifloxacin pharmacokinetics may contribute to differences in therapeutic response and has been partially attributed to genetic factors affecting drug transport.
Krstic Nakovska O +7 more
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MedComm, 2021 Multidrug resistance (MDR) has been extensively reported in colorectal cancer patients, which remains a major cause of chemotherapy failure. One of the critical mechanisms of MDR in colorectal cancer is the reduced intracellular drug level led by the ...
Zhe-Sheng Chen, Zi-Ning Lei, Zhuo-Xun Wu
exaly +2 more sources
Lack of Association between C1236T, G2677T/A and C3435T Variants of the ABCB1 Gene and Imatinib Response in Iranian Chronic Myeloid Leukemia Patients [PDF]
Journal of Sciences, Islamic Republic of Iran, 2021 Imatinib introduction caused to improve the clinical outcomes of chronic myeloid leukemia (CML) patients. Despite the significant effects of Imatinib, pharmacogenetic variables induced treatment resistant is also observed.
Maedeh Khosravi +7 more
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Minimally invasive differential diagnosis of melanocytic intraocular neoplasms
Российский офтальмологический журнал, 2023 Purpose: to analyze the mutation frequency of the GNAQ/GNA11 gene in circulating tumor DNA and genotypes of the polymorphic marker C3435T of the ABCB1 gene in a large sample of patients with intraocular melanocytic neoplasms (IMN).Material and methods ...
A. Yu. Tsygankov +4 more
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Radiology and Oncology, 2023 Deregulation of the apoptotic process underlies the pathogenesis of many cancers, including leukemia, but is also very important for the success of chemotherapy treatment.
Pravdic Zlatko +6 more
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ABCB1 polymorphism in clopidogrel-treated Montenegrin patients
Open Life Sciences, 2021 Clopidogrel is an antiplatelet drug that displays significant interindividual variability in treatment response. Its bioavailability depends on the function of P-glycoprotein (P-gp), which is coded by a highly polymorphic ABCB1 gene.
Mugosa Snezana +4 more
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Molecular Cancer, 2022 Highlights ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor.
Yuqi Yang +8 more
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