Results 1 to 10 of about 21,080 (149)
Acta Pharmaceutica Sinica B, 2021 Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due
Xu Wu, Stella Chai, Chunyuan Zhang
exaly +3 more sources
Cloning, structural and functional characterization of the ABCB1 transporter of the Eurasian bullfinch (Pyrrhula pyrrhula) [PDF]
Frontiers in Veterinary ScienceSuspected ivermectin hypersensitivity has been reported in the Eurasian bullfinch and some related passerine birds. However, the underlying cause and pharmacological mechanism have not been systematically investigated.
Katharina Heilmann +5 more
doaj +2 more sources
The Antidepressant Drug Clomipramine Inhibits the ABC Transporter BmrA. [PDF]
ChembiochemDrug uptake is constrained by epithelial barriers, such as the intestine and the blood–brain barrier, which express efflux pumps such as the ABC‐transporter ABCB1. Therefore, drugs targeting the central nervous system frequently require co‐administration of efflux inhibitors to facilitate sufficient target engagement. Conversely, certain drugs designed
Hellmann N +3 more
europepmc +2 more sources
Erdafitinib Antagonizes ABCB1-Mediated Multidrug Resistance in Cancer Cells
Frontiers in Oncology, 2020 ABCB1 overexpression is known to contribute to multidrug resistance (MDR) in cancers. Therefore, it is critical to find effective drugs to target ABCB1 and overcome MDR.
Weiguo Feng +2 more
exaly +3 more sources
MedComm, 2021 Multidrug resistance (MDR) has been extensively reported in colorectal cancer patients, which remains a major cause of chemotherapy failure. One of the critical mechanisms of MDR in colorectal cancer is the reduced intracellular drug level led by the ...
Zi-Ning Lei, Qiu-Xu Teng, Zhuo-Xun Wu
exaly +2 more sources
Lack of Association between C1236T, G2677T/A and C3435T Variants of the ABCB1 Gene and Imatinib Response in Iranian Chronic Myeloid Leukemia Patients [PDF]
Journal of Sciences, Islamic Republic of Iran, 2021 Imatinib introduction caused to improve the clinical outcomes of chronic myeloid leukemia (CML) patients. Despite the significant effects of Imatinib, pharmacogenetic variables induced treatment resistant is also observed.
Maedeh Khosravi +7 more
doaj +1 more source
H89 Reverses Multidrug Resistance in Colorectal Cancer by Inhibiting the ATPase Activity of ABCB1 [PDF]
BiomedicinesBackground: Multidrug resistance (MDR) remains a major obstacle in cancer chemotherapy, and overexpression of ABCB1 plays a critical role in the pathogenesis of MDR.
Wei-Jing Liu +9 more
doaj +2 more sources
Minimally invasive differential diagnosis of melanocytic intraocular neoplasms
Российский офтальмологический журнал, 2023 Purpose: to analyze the mutation frequency of the GNAQ/GNA11 gene in circulating tumor DNA and genotypes of the polymorphic marker C3435T of the ABCB1 gene in a large sample of patients with intraocular melanocytic neoplasms (IMN).Material and methods ...
A. Yu. Tsygankov +4 more
doaj +1 more source
Radiology and Oncology, 2023 Deregulation of the apoptotic process underlies the pathogenesis of many cancers, including leukemia, but is also very important for the success of chemotherapy treatment.
Pravdic Zlatko +6 more
doaj +1 more source
ABCB1 polymorphism in clopidogrel-treated Montenegrin patients
Open Life Sciences, 2021 Clopidogrel is an antiplatelet drug that displays significant interindividual variability in treatment response. Its bioavailability depends on the function of P-glycoprotein (P-gp), which is coded by a highly polymorphic ABCB1 gene.
Mugosa Snezana +4 more
doaj +1 more source