Results 41 to 50 of about 26,813 (237)
Медицинский совет, 2020 Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD).
A. I. Skripka +12 more
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, 2012 Objective ATP-binding cassette, sub-family B MDR/TAP, member 1 ABCB1 is a drug transporter protein expressed on the epithelial cells of the intestine and the endothelial cells of the blood-brain barrier.
LIN, KEH-MING;CHIU, YEN-FENG;SHEN, WINSTON W.;LIU, SHU CHIH;LU, SHAO-CHUN;LIU, CHIA-YIH;HSIAO, MEI-CHUN;TANG, HWA-SHENG;LIU, SHEN-ING;WU, CHI-SHIN;TSOU, HSIAO-HUI;TSAI, MING-HSIEN;KUO, HSIANG-WEI;LIU, YU-LI +1 more
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Ethylmethylhydroxypyridine Succinate Is an Inhibitor but Not a Substrate of ABCB1 and SLCO1B1
Pharmaceuticals, 2023 2-Ethyl-6-methyl-3-hydroxypyridine succinate (EMHPS, Mexidol) is an original antioxidant and an anti-ischemic drug with the possibility of wide applications in the complex therapy of diseases, accompanied by the development of oxidative stress and ischemia; for example, ischemic stroke, chronic cerebral ischemia, and chronic heart failure.
Aleksey V. Shchulkin +7 more
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, 2011 Objective The ABCB1 haplotype combinations have been demonstrated to be associated with epilepsy treatment outcomes. The aim of this study is to investigate whether ABCB1 haplotype combinations would affect P- glycoprotein ( Pgp) function and impact the ...
洪靚娟;陳至全;林君榮;劉宏輝 +1 more
core +1 more source
Molecules, 2016 In recent years, tyrosine kinase inhibitors (TKIs) have been shown capable of inhibiting the ATP-binding cassette (ABC) transporter-mediated multidrug resistance (MDR). In this study, we determine whether osimertinib, a novel selective, irreversible EGFR
Xiao-Yu Zhang +8 more
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Frontiers in Pharmacology, 2021 The emergence of multidrug resistance (MDR) has been a major issue for effective cancer chemotherapy as well as targeted therapy. One prominent factor that causes MDR is the overexpression of ABCB1 transporter.
Zhuo-Xun Wu +8 more
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Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function [PDF]
Biochemical Pharmacology, 2009 The effectiveness of chemotherapeutic treatment is usually limited by the overexpression of adenosine triphosphate binding cassette (ABC) transporters, which mediate multidrug resistance (MDR) by acting as efflux pumps to remove chemotherapeutic agents from MDR cancer cells. Thus, the inhibition of ABC transporters may represent a promising strategy to
Chun-ling, Dai +12 more
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Interindividual epigenetic variation in ABCB1 promoter and its relationship with ABCB1 expression and function in healthy Chinese subjects [PDF]
British Journal of Clinical Pharmacology, 2015 AimInterindividual epigenetic variation is likely to be an important mechanism contributing to the interindividual variability in the expression and function of ATP‐binding cassette, sub‐family B, member 1 (ABCB1). The aim of the present study was to explore the effect of interindividual epigenetic variability in the ABCB1 promoter on ABCB1 expression ...
Lan-Xiang, Wu +6 more
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Differential effect of ABCB1 haplotypes on promoter activity [PDF]
Pharmacogenetics and Genomics, 2018 Promoter single-nucleotide polymorphisms (SNPs) of the ABCB1 gene, encoding the placental efflux transporter P-glycoprotein, can affect its expression and alter xenobiotic transfer from the maternal to the fetal circulation. Because SNPs are arranged in specific combinations as defined haplotypes, the aims of this study were to: (i) determine the ...
Jordan T, Speidel +2 more
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Cell Communication and Signaling, 2022 Background Multidrug resistance (MDR) is a complex phenomenon that frequently leads to chemotherapy failure during cancer treatment. The overexpression of ATP-binding cassette (ABC) transporters represents the major mechanism contributing to MDR. To date,
Yuchen Zhang +9 more
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