Results 1 to 10 of about 43,637 (267)
Journal of Pharmacological Sciences, 2004 A relatively large amount of human liver tissue was required to determine the exact activity of human hepatic CYP3A. Although, the quantity of available human liver tissue samples is limited.
, Toshio Kumai
exaly +6 more sources
Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: MDMA (methylenedioxymethamphetamine) is a synthetic compound, which is a structurally derivative of amphetamine. Also, it acts like an amphetamine, structurally, and functionally. MDMA uses mechanism-based inhibition, to inhibit isoenzyme CYP2D6.
Behjat Sheikholeslami +4 more
doaj +1 more source
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer [PDF]
Acta Pharmacologica Sinica, 2020 Alflutinib (AST2818) is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations. Previous study has shown that after multiple dosages, alflutinib exhibits nonlinear pharmacokinetics and displays a time- and dose-dependent increase in the apparent clearance, probably due to its
Liu, Xiao-yun +8 more
openaire +2 more sources
Hepatitis C virus infection: Epidemiology in Egypt, Pathophysiology and DAAs-based therapy
Archives of Pharmaceutical Sciences Ain Shams University, 2021 Hepatitis C virus (HCV) was first identified in 1989. The situation in Egypt is really dire. The prevalence of HCV genotype 4 (GT-4) is 14.7%. About 10% of the middle-aged population (ages 15 to 59) is infected with HCV.
Heba Elbadawy +2 more
doaj +1 more source
Фармакокинетика и Фармакодинамика, 2022 Relevance of the study: The quantification of endogenous substances is an important task in experimental and clinical pharmacology. In the case of working with endogenous compounds, certain difficulties arise.
V. V. Smirnov +3 more
doaj +1 more source
CYP3A4 and CYP3A5genotyping by Pyrosequencing [PDF]
BMC Medical Genetics, 2005 Human cytochrome P450 3A enzymes, particularly CYP3A4 and CYP3A5, play an important role in drug metabolism. CYP3A expression exhibits substantial interindividual variation, much of which may result from genetic variation. This study describes Pyrosequencing assays for key SNPs in CYP3A4 (CYP3A4*1B, CYP3A4*2, and CYP3A4*3) and CYP3A5 (CYP3A5*3C and ...
McLeod Howard L +2 more
openaire +3 more sources
Direct Acting Antiviral Drugs: Pharmacokinetics and Drug-Drug Interactions
Archives of Pharmaceutical Sciences Ain Shams University, 2022 Hepatitis C (HCV) is a widespread health issue, which can lead to hepatic cirrhosis, liver failure, and liver cancer. Nearly 2% of the world's population or > 185 million people are chronically infected with HCV; the management of HCV and the rate of ...
Marina Barakat +3 more
doaj +1 more source
In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes
Pharmaceutical Biology, 2021 Context Peucedanol is a major extract of Peucedanum japonicum Thunb. (Apiaceae) roots, which is a commonly used herb in paediatrics. Its interaction with cytochrome P450 enzymes (CYP450s) would lead to adverse effects or even failure of therapy ...
Cun Zhang +4 more
doaj +1 more source
CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing [PDF]
Pharmacogenetics and Genomics, 2016 Cytochrome P450 3A4 (CYP3A4) metabolizes 30-50% of clinically used drugs. Large interperson variability in CYP3A4 activity affects response to CYP3A4 substrate drugs. We had demonstrated that an intronic single nucleotide polymorphism rs35599367 (CYP3A4*22, located in intron 6) reduces mRNA/protein expression; however, the underlying mechanism remained
Danxin, Wang, Wolfgang, Sadee
openaire +2 more sources
An epoxidation mechanism of carbamazepine by CYP3A4 [PDF]
Bioorganic & Medicinal Chemistry, 2008 Human CYP3A4 catalyzes the 10,11-epoxidation of carbamazepine (CBZ). However, the epoxide is less stable in terms of potential energy than hydroxides of the six-membered aromatic ring. To clarify the reason why CYP3A4 produces such an energetically unfavorable compound, the mechanism of epoxidation of CBZ by CYP3A4 was investigated by theoretical ...
Hata, Masayuki +8 more
openaire +2 more sources