Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: MDMA (methylenedioxymethamphetamine) is a synthetic compound, which is a structurally derivative of amphetamine. Also, it acts like an amphetamine, structurally, and functionally. MDMA uses mechanism-based inhibition, to inhibit isoenzyme CYP2D6.
Behjat Sheikholeslami +4 more
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Hepatitis C virus infection: Epidemiology in Egypt, Pathophysiology and DAAs-based therapy
Archives of Pharmaceutical Sciences Ain Shams University, 2021 Hepatitis C virus (HCV) was first identified in 1989. The situation in Egypt is really dire. The prevalence of HCV genotype 4 (GT-4) is 14.7%. About 10% of the middle-aged population (ages 15 to 59) is infected with HCV.
Heba Elbadawy +2 more
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Фармакокинетика и Фармакодинамика, 2022 Relevance of the study: The quantification of endogenous substances is an important task in experimental and clinical pharmacology. In the case of working with endogenous compounds, certain difficulties arise.
V. V. Smirnov +3 more
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Direct Acting Antiviral Drugs: Pharmacokinetics and Drug-Drug Interactions
Archives of Pharmaceutical Sciences Ain Shams University, 2022 Hepatitis C (HCV) is a widespread health issue, which can lead to hepatic cirrhosis, liver failure, and liver cancer. Nearly 2% of the world's population or > 185 million people are chronically infected with HCV; the management of HCV and the rate of ...
Marina Barakat +3 more
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In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes
Pharmaceutical Biology, 2021 Context Peucedanol is a major extract of Peucedanum japonicum Thunb. (Apiaceae) roots, which is a commonly used herb in paediatrics. Its interaction with cytochrome P450 enzymes (CYP450s) would lead to adverse effects or even failure of therapy ...
Cun Zhang +4 more
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In vitro inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes
Pharmaceutical Biology, 2020 Context Ganoderic acid A (GAA) is usually used to prevent cancers or other diseases, which make it likely to be used with other drugs metabolized by cytochromes P450.
Shangchen Xu +5 more
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Influence of quercetin and chrysin on the intestinal permeability of paclitaxel, a substrate of P-glycoprotein and CYP3A4 using in vitro rat gut sacs [PDF]
Trends in Pharmaceutical Sciences, 2019 P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) play a significant role in the disposition and elimination of drugs. The objective of this study was to investigate the mechanism underlying the interaction between paclitaxel (substrate of P-gp and ...
Ravindra Babu Pingili +3 more
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SLCO1B1 and CYP3A4 allelic variants associated with pharmacokinetic interactions and adverse reactions induced by simvastatin and atorvastatin used in Peru: Clinical implications [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Statins reduce the risk of stroke and prevent cardiac events in people with atherosclerosis and diabetes mellitus; and could affect the proliferation, migration, and survival of cancer cells.
Angel T. Alvarado +16 more
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Pharmaceutical Biology, 2020 Context Ligustrazine and valsartan are commonly used drugs in the treatment of cardiac and cardiovascular disease. Objective The interaction between ligustrazine and valsartan was studied to investigate the effect of ligustrazine on the pharmacokinetics ...
Yang Liu, Jiaqi Zhang, Di Wu, Liran Cui
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In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes
Pharmaceutical Biology, 2017 Context: Dihydromyricetin (DHM) is the most abundant and active flavonoid component isolated from Ampelopsis grossedentata (Hand-Mazz) W.T. Wang (Vitaceae) and it possesses numerous pharmacological activities. However, whether DHM affects the activity of
Lu Liu +3 more
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