Results 1 to 10 of about 76,898 (162)
Journal of Pharmacological Sciences, 2004 A relatively large amount of human liver tissue was required to determine the exact activity of human hepatic CYP3A. Although, the quantity of available human liver tissue samples is limited.
Toshio Kumai, Naoki Matsumoto
exaly +3 more sources
Hepatitis C virus infection: Epidemiology in Egypt, Pathophysiology and DAAs-based therapy
Archives of Pharmaceutical Sciences Ain Shams University, 2021 Hepatitis C virus (HCV) was first identified in 1989. The situation in Egypt is really dire. The prevalence of HCV genotype 4 (GT-4) is 14.7%. About 10% of the middle-aged population (ages 15 to 59) is infected with HCV.
Heba Elbadawy +2 more
doaj +1 more source
Фармакокинетика и Фармакодинамика, 2022 Relevance of the study: The quantification of endogenous substances is an important task in experimental and clinical pharmacology. In the case of working with endogenous compounds, certain difficulties arise.
V. V. Smirnov +3 more
doaj +1 more source
SLCO1B1 and CYP3A4 allelic variants associated with pharmacokinetic interactions and adverse reactions induced by simvastatin and atorvastatin used in Peru: Clinical implications [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Statins reduce the risk of stroke and prevent cardiac events in people with atherosclerosis and diabetes mellitus; and could affect the proliferation, migration, and survival of cancer cells.
Angel T. Alvarado +16 more
doaj +1 more source
Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement [PDF]
Advanced Pharmaceutical Bulletin, 2020 In the treatment of cancer, chemotherapy plays an important role though the efficacy of anti-cancer drug administered orally is limited, due to their poor solubility in physiological medium, inability to cross biological membrane, high Para-glycoprotein (
Shashank Chaturvedi +2 more
doaj +1 more source
Hepatology Communications, 2021 In drug development, a system for predicting drug metabolism and drug‐induced toxicity is necessary to ensure drug safety. Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) is an important drug‐metabolizing enzyme expressed in the liver and small ...
Sayaka Deguchi +8 more
doaj +1 more source
Scientific Reports, 2021 Caco-2 cells are widely used as an in vitro intestinal epithelial cell model because they can form a monolayer and predict drug absorption with high accuracy. However, Caco-2 cells hardly express cytochrome P450 (CYP), a drug-metabolizing enzyme.
Moe Ichikawa +5 more
doaj +1 more source
Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: MDMA (methylenedioxymethamphetamine) is a synthetic compound, which is a structurally derivative of amphetamine. Also, it acts like an amphetamine, structurally, and functionally. MDMA uses mechanism-based inhibition, to inhibit isoenzyme CYP2D6.
Behjat Sheikholeslami +4 more
doaj +1 more source
In vitro inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes
Pharmaceutical Biology, 2020 Context Ganoderic acid A (GAA) is usually used to prevent cancers or other diseases, which make it likely to be used with other drugs metabolized by cytochromes P450.
Shangchen Xu +5 more
doaj +1 more source
Di-san junyi daxue xuebao, 2022 Objective To explore the differences of postoperative patient-controlled intravenous analgesia (PCIA) with sufentanil in the patients with different CYP3A4 and CYP3A5 genotypes after laparoscopic surgery. Methods According to CYP3A4 and CYP3A5 genotypes,
GU Li +4 more
doaj +1 more source