Results 41 to 50 of about 56,913 (295)

In vitro inhibitory effects of kaempferitrin on human liver cytochrome P450 enzymes

Pharmaceutical Biology, 2019
Context: Kaempferitrinis (KF) is a bioactive flavonoid and possesses numerous pharmacological activities. However, whether KF affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear.
Ning Zhang, Jing Liu, Zhixia Chen, Wenwen Dou   +3 more
doaj   +1 more source

GENETIC PREDICTORS OF INTENSIVE LIPID-LOWERING THERAPY EFFICACY AND ITS ANTI-INFLAMMATORY EFFECTS IN VERY HIGH CARDIOVASCULAR RISK PATIENTS

Рациональная фармакотерапия в кардиологии, 2017
Aim. To study the anti-inflammatory effects of intensive lipid-lowering therapy and genetic predictors of its effectiveness in patients with very high cardiovascular risk.Material and methods.
M. A. Vorobyeva, M. M. Azova, O. O. Gigani, I. V. Garmash, S. V. Villevalde, Zh. D. Kobalava   +5 more
doaj   +1 more source

Panax notoginseng saponins increases the blood concentration of nifedipine by inhibiting CYP3A4 enzyme through PXR- and CAR-Mediated pathway

World Journal of Traditional Chinese Medicine, 2021
Objective: To explore the mechanism underlying the effect of Panax notoginseng saponins (PNS) on the pharmacokinetics of nifedipine (NF) in rats. Materials and Methods: Twenty-four rats were randomly divided into blank (BL) group, PNS group, NF group ...
Qiu-Hong Li, Jiao Zhao, Ai-Xia Ju, Yong Hu, Qing-Song Qie, Hong-Bin Xiao, Guang Xu, Xi-Jun Wang   +7 more
doaj   +1 more source

Pharmacogenetic and Clinical Predictors of Clopidogrel Insufficiency in a Patient with Atherosclerosis Obliterans of the Lower Extremities: Clinical Case

Рациональная фармакотерапия в кардиологии, 2018
The considered clinical case of combination of multifocal atherosclerotic vascular lesion with type 2 diabetes mellitus and liver fibrosis demonstrates a combination of polyvalent risk factors  for resistance to antiplatelet therapy with clopidogrel. The
M. A. Andreyanova, K. B. Mirzaev, D. A. Sychev, K. A. Ryzhikova, A. V. Pokrovsky, A. F. Kharazov   +5 more
doaj   +1 more source

Effects of triptolide on pharmacokinetics of amlodipine in rats by using LC–MS/MS

Pharmaceutical Biology, 2018
Context: Triptolide and amlodipine are often simultaneously used for reducing urine protein excretion after renal transplantation in China clinics. Objective: This study investigated the effects of triptolide on the pharmacokinetics of amlodipine in male
Chengyin Zhang, Zhiqiang Gao, Lijuan Niu, Xuexun Chen   +3 more
doaj   +1 more source

The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro

Pharmaceutical Biology, 2021
Context The interaction between nobiletin and anemarsaponin BII could affect the pharmacological activity of these two drugs during their combination.
Jie Zhang, Meiling Fan, Xia Yu, Bin Zhang   +3 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Impact of CYP3A4 and CYP3A5 Genetic Variants on Tacrolimus Dosing and Therapeutic Outcomes in Kidney Transplant Recipients

Majalah Kedokteran Bandung
Tacrolimus is the cornerstone of immunosuppressive therapy in kidney transplantation; however, its narrow therapeutic index and variable metabolism make dose optimization difficult.
Hafiza Fareeha Bashir, Rasheeda Bashir, Farheen Aslam, Sana Rafaqat, Amina Latif, Areej Fatima, Zunaira Tahir   +6 more
doaj   +1 more source

Inhibitory Effects of Vegetable Juices on CYP3A4 Activity in Recombinant CYP3A4 and LS180 Cells

Biological & Pharmaceutical Bulletin, 2016
It is thought that eating habits induces individual variation in intestinal absorption and metabolism of drugs. The objective of this research was to clarify the influence of vegetables juices on CYP3A4 activity, which is an important enzyme in intestine. Five vegetables juices (VJ-o, Kagome Original(®); VJ-g, Kagome 30 kinds of vegetables and fruits(®)
Tsujimoto, Masayuki, Uchida, Tomoe, Kozakai, Hiroyuki, Yamamoto, Saori, Minegaki, Tetsuya, Nishiguchi, Kohshi   +5 more
openaire   +3 more sources

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE).
Sarah L. Patterson, Russell Ellyson, Jessica Fitzpatrick, Ghizlane Yaakoubi, Bradley Pearce, S. Sam Lim, Jinoos Yazdany, Laura C. Plantinga   +7 more
wiley   +1 more source